| Entry |
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| Name |
23S rRNA (guanine745-N1)-methyltransferase;
Rlma(I);
Rlma1;
23S rRNA m1G745 methyltransferase;
YebH;
RlmAI methyltransferase;
ribosomal RNA(m1G)-methylase (ambiguous);
rRNA(m1G)methylase (ambiguous);
RrmA (ambiguous);
23S rRNA:m1G745 methyltransferase
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| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
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| Sysname |
S-adenosyl-L-methionine:23S rRNA (guanine745-N1)-methyltransferase
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| Reaction(IUBMB) |
S-adenosyl-L-methionine + guanine745 in 23S rRNA = S-adenosyl-L-homocysteine + N1-methylguanine745 in 23S rRNA [RN: R07233]
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| Reaction(KEGG) |
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| Substrate |
S-adenosyl-L-methionine [CPD: C00019];
guanine745 in 23S rRNA
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| Product |
S-adenosyl-L-homocysteine [CPD: C00021];
N1-methylguanine745 in 23S rRNA
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| Comment |
The enzyme specifically methylates guanine745 at N1 in 23S rRNA.
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| History |
EC 2.1.1.187 created 1976 as EC 2.1.1.51, part transferred 2010 to EC 2.1.1.187
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| Orthology |
| K00563 | 23S rRNA (guanine745-N1)-methyltransferase |
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| Genes |
» show all
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| Reference |
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| Authors |
Liu M, Novotny GW, Douthwaite S |
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| Title |
Methylation of 23S rRNA nucleotide G745 is a secondary function of the RlmAI methyltransferase. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Gustafsson C, Persson BC |
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| Title |
Identification of the rrmA gene encoding the 23S rRNA m1G745 methyltransferase in Escherichia coli and characterization of an m1G745-deficient mutant. |
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| Journal |
J Bacteriol 180:359-65 (1998) |
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| Sequence |
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| Reference |
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| Authors |
Das K, Acton T, Chiang Y, Shih L, Arnold E, Montelione GT |
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| Title |
Crystal structure of RlmAI: implications for understanding the 23S rRNA G745/G748-methylation at the macrolide antibiotic-binding site. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Hansen LH, Kirpekar F, Douthwaite S |
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| Title |
Recognition of nucleotide G745 in 23 S ribosomal RNA by the rrmA methyltransferase. |
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| Journal |
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| Reference |
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| Authors |
Liu M, Douthwaite S |
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| Title |
Methylation at nucleotide G745 or G748 in 23S rRNA distinguishes Gram-negative from Gram-positive bacteria. |
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| Journal |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.1.1.187 |
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| LinkDB |
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