Entry
Name
cypemycin N-terminal methyltransferase;
CypM
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:N-terminal L-alanine-[cypemycin] N-methyltransferase
Reaction(IUBMB)
2 S-adenosyl-L-methionine + N-terminal L-alanine-[cypemycin] = 2 S-adenosyl-L-homocysteine + N-terminal N,N-dimethyl-L-alanine-[cypemycin]
Substrate
S-adenosyl-L-methionine [CPD:
C00019 ];
N-terminal L-alanine-[cypemycin]
Product
S-adenosyl-L-homocysteine [CPD:
C00021 ];
N-terminal N,N-dimethyl-L-alanine-[cypemycin]
Comment
The enzyme, isolated from the bacterium Streptomyces sp. OH-4156, can methylate a variety of linear oligopeptides, cyclic peptides such as nisin and haloduracin, and the epsilon-amino group of lysine [2]. Cypemycin is a peptide antibiotic, a member of the linaridins, a class of posttranslationally modified ribosomally synthesized peptides.
History
EC 2.1.1.301 created 2014
Orthology
K21459 cypemycin N-terminal methyltransferase
Genes
Taxonomy
Reference
Authors
Claesen J, Bibb M
Title
Genome mining and genetic analysis of cypemycin biosynthesis reveal an unusual class of posttranslationally modified peptides.
Journal
Sequence
Reference
Authors
Zhang Q, van der Donk WA
Title
Catalytic promiscuity of a bacterial alpha-N-methyltransferase.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.1.1.301
LinkDB
All DBs