Entry Name cypemycin N-terminal methyltransferase;
Class Transferases;BRITE hierarchy
Sysname S-adenosyl-L-methionine:N-terminal L-alanine-[cypemycin] N-methyltransferase
Reaction(IUBMB) 2 S-adenosyl-L-methionine + N-terminal L-alanine-[cypemycin] = 2 S-adenosyl-L-homocysteine + N-terminal N,N-dimethyl-L-alanine-[cypemycin]
Substrate S-adenosyl-L-methionine [CPD:
C00019 ];
N-terminal L-alanine-[cypemycin]
Product S-adenosyl-L-homocysteine [CPD:
C00021 ];
N-terminal N,N-dimethyl-L-alanine-[cypemycin]
Comment The enzyme, isolated from the bacterium Streptomyces sp. OH-4156, can methylate a variety of linear oligopeptides, cyclic peptides such as nisin and haloduracin, and the epsilon-amino group of lysine [2]. Cypemycin is a peptide antibiotic, a member of the linaridins, a class of posttranslationally modified ribosomally synthesized peptides.
History EC 2.1.1.301 created 2014
Orthology K21459 cypemycin N-terminal methyltransferase
Genes Taxonomy Reference Authors Claesen J, Bibb M
Title Genome mining and genetic analysis of cypemycin biosynthesis reveal an unusual class of posttranslationally modified peptides.
Journal Sequence Reference Authors Zhang Q, van der Donk WA
Title Catalytic promiscuity of a bacterial alpha-N-methyltransferase.
Journal Sequence Other DBs ExPASy - ENZYME nomenclature database: 2.1.1.301
LinkDB All DBs
