KEGG   ENZYME: 2.1.1.304
Entry
EC 2.1.1.304                Enzyme                                 
Name
L-tyrosine C3-methyltransferase;
SfmM2;
SacF
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:L-tyrosine C3-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + L-tyrosine = S-adenosyl-L-homocysteine + 3-methyl-L-tyrosine [RN:R10964]
Reaction(KEGG)
R10964
Substrate
S-adenosyl-L-methionine [CPD:C00019];
L-tyrosine [CPD:C00082]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
3-methyl-L-tyrosine [CPD:C20800]
Comment
The enzyme from the bacterium Streptomyces lavendulae is involved in biosynthesis of saframycin A, a potent antitumor antibiotic that belongs to the tetrahydroisoquinoline family.
History
EC 2.1.1.304 created 2014
Orthology
K21460  L-tyrosine C(3)-methyltransferase
Genes
LPOPI6N93_03605
POIBOP93_17430
NBRO3I_021170
NOZDMB37_35935
NWLNWFMUON74_37020
SBHSBI_00214
SRWTUE45_pSRc_0392(crtF)
SPAVSpa2297_02655
SGSAVL59_15490
SNWBBN63_30130
SDXC4B68_39100
AMYYYIM_25125(tcmN2)
SSYIEKG83_27610
KPHYAOZ06_21630
ALOCRK56714
MCRAID554_15035
AEYCDG81_20600
TERTery_3121
PAGHNIES204_43770
 » show all
Reference
1  [PMID:22187429]
  Authors
Tang MC, Fu CY, Tang GL
  Title
Characterization of SfmD as a Heme peroxidase that catalyzes the regioselective hydroxylation of 3-methyltyrosine to 3-hydroxy-5-methyltyrosine in saframycin A biosynthesis.
  Journal
J Biol Chem 287:5112-21 (2012)
DOI:10.1074/jbc.M111.306316
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.304
IUBMB Enzyme Nomenclature: 2.1.1.304
ExPASy - ENZYME nomenclature database: 2.1.1.304
BRENDA, the Enzyme Database: 2.1.1.304
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