| Entry |
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| Name |
(-)-pluviatolide 4-O-methyltransferase;
OMT3 (gene name)
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| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
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| Sysname |
S-adenosyl-L-methionine:(-)-pluviatolide 4-O-methyltransferase
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| Reaction(IUBMB) |
S-adenosyl-L-methionine + (-)-pluviatolide = S-adenosyl-L-homocysteine + (-)-bursehernin [RN: R11230]
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| Reaction(KEGG) |
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| Substrate |
S-adenosyl-L-methionine [CPD: C00019];
(-)-pluviatolide [CPD: C21191]
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| Product |
S-adenosyl-L-homocysteine [CPD: C00021];
(-)-bursehernin [CPD: C21183]
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| Comment |
The enzyme, characterized from the plant Sinopodophyllum hexandrum, is involved in the biosynthetic pathway of podophyllotoxin, a non-alkaloid toxin lignan whose derivatives are important anticancer drugs.
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| History |
EC 2.1.1.323 created 2016
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| Pathway |
| ec00998 | Biosynthesis of various secondary metabolites - part 2 |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K21203 | (-)-pluviatolide 4-O-methyltransferase |
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| Reference |
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| Authors |
Lau W, Sattely ES |
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| Title |
Six enzymes from mayapple that complete the biosynthetic pathway to the etoposide aglycone. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.1.1.323 |
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| LinkDB |
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