KEGG   ENZYME: 2.1.1.354Help
Entry
EC 2.1.1.354                Enzyme                                 

Name
[histone H3]-lysine4 N-trimethyltransferase;
KMT2A (gene name);
KMT2B (gene name);
KMT2C (gene name);
KMT2D (gene name);
KMT2E (gene name);
KMT2F (gene name);
KMT2G (gene name);
KMT2H (gene name);
KMT3C (gene name);
KMT3D (gene name);
KMT3E (gene name);
KMT7 (gene name);
PRDM7 (gene name);
PRDM9 (gene name);
MLL1 (gene name);
MLL2 (gene name);
MLL3 (gene name);
MLL4 (gene name);
MLL5 (gene name);
SETD1A (gene name);
ASH1L (gene name);
SMYD1 (gene name);
SMYD2 (gene name);
SMYD3 (gene name);
SET7/9 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:[histone H3]-L-lysine4 N6-methyltransferase
Reaction(IUBMB)
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine4 = 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4 (overall reaction);
(1a) S-adenosyl-L-methionine + a [histone H3]-L-lysine4 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine4;
(1b) S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine4 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine4;
(1c) S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine4 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine4
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
[histone H3]-L-lysine4;
[histone H3]-N6-methyl-L-lysine4;
[histone H3]-N6,N6-dimethyl-L-lysine4
Product
S-adenosyl-L-homocysteine [CPD:C00021];
[histone H3]-N6,N6,N6-trimethyl-L-lysine4;
[histone H3]-N6-methyl-L-lysine4;
[histone H3]-N6,N6-dimethyl-L-lysine4
Comment
This entry describes several enzymes that successively methylate the L-lysine4 residue of histone H3 (H3K4), ultimately generating a trimethylated form. These modifications influence the binding of chromatin-associated proteins. In most cases the trimethylation of this position is associated with gene activation. Unlike the other enzymes, KMT7 catalyses only monomethylation.
History
EC 2.1.1.354 created 1976 as EC 2.1.1.43, modified 1982, modified 1983, part transferred 2019 to EC 2.1.1.354
Pathway
ec00310  Lysine degradation
ec01100  Metabolic pathways
Orthology
K06101  [histone H3]-lysine4 N-trimethyltransferase ASH1L
K09186  [histone H3]-lysine4 N-trimethyltransferase MLL1
K09187  [histone H3]-lysine4 N-trimethyltransferase MLL2
K09188  [histone H3]-lysine4 N-trimethyltransferase MLL3
K09189  [histone H3]-lysine4 N-trimethyltransferase MLL5
K11422  [histone H3]-lysine4 N-trimethyltransferase SETD1
K11426  [histone H3]-lysine4/36 N-trimethyltransferase SMYD
K11431  [histone H3]-lysine4 N-trimethyltransferase SETD7
K14959  [histone H3]-lysine4 N-trimethyltransferase MLL4
K20796  [histone H3]-lysine4 N-trimethyltransferase PRDM7/9
K22748  [histone H3]-lysine4 N-trimethyltransferase ATXR3
Genes
HSA: 11105(PRDM7) 150572(SMYD1) 23067(SETD1B) 4297(KMT2A) 55870(ASH1L) 55904(KMT2E) 56950(SMYD2) 56979(PRDM9) 58508(KMT2C) 64754(SMYD3) 8085(KMT2D) 80854(SETD7) 9739(SETD1A) 9757(KMT2B)
PTR: 100610362(KMT2D) 107971434(ASH1L) 451587(KMT2A) 455959(KMT2B) 457729(SMYD2) 457870(SMYD3) 459386(SMYD1) 461944(PRDM9) 463640(KMT2E) 463875(KMT2C) 468101(SETD1A) 473295(SETD1B) 737682(SETD7)
PPS: 100971786(SMYD2) 100972983(SETD1A) 100979249(KMT2B) 100979709(ASH1L) 100981554(SETD7) 100982828(KMT2E) 100983230(SMYD1) 100984332(KMT2A) 100985657(SETD1B) 100990317(SMYD3) 100992231(KMT2C) 100993054(PRDM9) 100995808(KMT2D)
GGO: 101124677(SETD1B) 101126745(SETD1A) 101129366(KMT2A) 101134264(ASH1L) 101134599(KMT2C) 101135995(PRDM7) 101136369(PRDM9) 101136477(SETD7) 101139923(KMT2B) 101144774(KMT2D) 101144971(KMT2E) 101145998(SMYD3) 101146341(SMYD1) 101147890(SMYD2)
PON: 100172280(SMYD1) 100173903(KMT2E) 100432076(SETD1A) 100435324(SETD1B) 100439269(SMYD3) 100439693(PRDM9) 100439768(SMYD2) 100440639(PRDM7) 100441102(KMT2A) 100441715(KMT2D) 100442005(KMT2B) 100449956(SETD7)
NLE: 100579604(SMYD3) 100580011(ASH1L) 100583589(PRDM9) 100584028(SETD1B) 100586637(KMT2D) 100594433(KMT2B) 100600051(KMT2E) 100602268(SETD1A) 100602353(SETD7) 100603309(SMYD2) 100603551(SMYD1) 100604245(KMT2A) 100607151(KMT2C) 100607333(PRDM7)
MCC: 695034(PRDM9) 697233(KMT2E) 698950(SMYD1) 700426(SETD7) 703402(SMYD3) 703717(SETD1B) 705511(KMT2A) 709375(SMYD2) 710795(KMT2D) 712416(SETD1A) 716753(KMT2C) 717778(ASH1L) 718835(KMT2B)
MCF: 101866311(KMT2A) 101867084(ASH1L) 101926094(KMT2E) 102115861(KMT2B) 102120149(SMYD3) 102120758(SMYD1) 102123137(SETD1B) 102123773(KMT2D) 102126119(PRDM7) 102128002(KMT2C) 102134166(SETD1A) 102136354(PRDM9) 102140141(SETD7) 102141885(SMYD2) 107128203
CSAB: 103215061(PRDM9) 103223879(ASH1L) 103226692(KMT2E) 103227268(KMT2C) 103230106(SMYD2) 103230910(SMYD3) 103231168(SETD1A) 103233507(PRDM7) 103234531(KMT2B) 103236281(SETD7) 103238253(KMT2D) 103239290(SETD1B) 103241358(SMYD1) 103248594(KMT2A)
RRO: 104654337(SETD7) 104659604(ASH1L) 104661596(SETD1A) 104665589(KMT2A) 104666361(SETD1B) 104667085(KMT2B) 104669844(SMYD2) 104674171(SMYD1) 104674292(PRDM7) 104675848(KMT2E) 104676513(SMYD3) 104677903 104678716(KMT2C) 104679726(KMT2D)
RBB: 108512323(KMT2B) 108515913 108518888(SMYD1) 108522758(SETD7) 108523124(KMT2C) 108523384(SETD1B) 108526582(SETD1A) 108526806(ASH1L) 108527467(SMYD2) 108528557(SMYD3) 108528969(PRDM7) 108531292(KMT2E) 108536375(KMT2A) 108543918(KMT2D)
CJC: 100388751(SMYD1) 100389921(KMT2E) 100391138(KMT2A) 100392519(SMYD3) 100393607(ASH1L) 100398610(SETD1B) 100399648(PRDM7) 100401397(KMT2C) 100404005(SMYD2) 100407541(KMT2B) 100408425(KMT2D) 100414241(SETD7) 100415635(SETD1A)
SBQ: 101029847(KMT2A) 101033099(KMT2E) 101034359(KMT2B) 101037539(KMT2D) 101039502(SMYD3) 101042903(SETD1A) 101043413(SMYD1) 101043552(KMT2C) 101045177(SETD1B) 101046051(ASH1L) 101047679(SETD7) 101048329 101049466 101050442(SMYD2)
MMU: 12180(Smyd1) 192195(Ash1l) 208043(Setd1b) 213389(Prdm9) 214162(Kmt2a) 226830(Smyd2) 231051(Kmt2c) 233904(Setd1a) 381022(Kmt2d) 69188(Kmt2e) 69726(Smyd3) 73251(Setd7) 75410(Kmt2b)
MCAL: 110290320(Smyd3) 110291461(Ash1l) 110291535(Setd7) 110294014(Kmt2e) 110295015(Setd1b) 110295273(Kmt2c) 110296132(Smyd1) 110297666(Kmt2b) 110298244(Setd1a) 110298532(Smyd2) 110301786(Kmt2a) 110310214(Kmt2d) 110312704
MPAH: 110312745(Setd1b) 110313856(Kmt2e) 110316198(Kmt2c) 110316349(Smyd1) 110317687(Setd1a) 110320364(Setd7) 110320636(Ash1l) 110321293(Smyd3) 110322084(Smyd2) 110327485(Kmt2a) 110334561(Kmt2d) 110338243 110338314(Kmt2b)
RNO: 100359816(Setd1b) 100362634(Kmt2d) 102550344(Kmt2b) 289372(Smyd2) 297333(Smyd1) 310638(Ash1l) 311968(Kmt2e) 315606(Kmt2a) 365155(Prdm9) 498295(Smyd3) 502710(Kmt2c) 689954(Setd7)
MUN: 110541941 110545142(Setd7) 110545334(Setd1b) 110547438(Kmt2d) 110548961(Ash1l) 110549115(Kmt2a) 110550986(Kmt2b) 110552814(Kmt2e) 110553406(Smyd2) 110557574(Smyd3) 110559772 110559774 110561122(Prdm9) 110562254(Smyd1) 110564205 110564208
CGE: 100750575(Kmt2b) 100752747(Prdm9) 100753294(Setd1b) 100753962(Setd1a) 100754103(Ash1l) 100756731(Kmt2e) 100760424(Kmt2a) 100761694(Smyd2) 100764840(Smyd3) 100765465(Kmt2d) 100766221(Smyd1) 100767175(Setd7) 100767367(Kmt2c)
NGI: 103726333(Setd1a) 103727065(Smyd2) 103729965(Kmt2b) 103732191(Kmt2e) 103737043(Smyd1) 103739104(Setd1b) 103742349(Prdm9) 103742371(Setd7) 103745326(Kmt2c) 103746872(Smyd3) 103748298(Kmt2a) 103750570(Kmt2d) 103750808(Ash1l)
HGL: 101698086 101698170(Kmt2c) 101699273(Kmt2b) 101701112 101702850(Setd1b) 101709197(Setd1a) 101712321(Kmt2e) 101715832(Setd7) 101716671(Kmt2a) 101718411(Kmt2d) 101718535(Smyd1) 101720447(Smyd2) 101722574(Smyd3) 101723836(Ash1l)
CCAN: 109674462 109675706(Smyd3) 109682842(Setd1a) 109684282(Kmt2e) 109685268(Kmt2c) 109686401(Setd1b) 109688014(Ash1l) 109689598(Kmt2b) 109689973(Kmt2a) 109691464(Setd7) 109694824(Kmt2d) 109695167 109700578(Smyd1) 109700718(Smyd2) 109702113 109702114
OCU: 100339782 100344249(SMYD2) 100347516(SMYD3) 100347618(SETD1B) 100347837(SETD7) 100353483(KMT2B) 100353688(KMT2C) 100353733(KMT2A) 100353840(KMT2E) 100354139(SETD1A) 100354541(ASH1L) 100355437(SMYD1) 100357052(KMT2D) 100358830(PRDM7) 100358832 103347079
TUP: 102469443(ASH1L) 102470517(SETD7) 102473382(KMT2A) 102474223(SETD1B) 102477772(KMT2B) 102478405(SETD1A) 102479012(KMT2C) 102480722(KMT2D) 102483069(KMT2E) 102483290(SMYD3) 102493552(SMYD1) 102496135(PRDM9) 102496151(SMYD2)
CFA: 100688666(KMT2B) 475758(SMYD1) 475895(KMT2E) 476079(SETD7) 479417(KMT2A) 480026(SMYD2) 480101(SMYD3) 480128(ASH1L) 486257(SETD1B) 486558(KMT2D) 489916(SETD1A) 611094(KMT2C)
VVP: 112916198(KMT2C) 112916807(SMYD1) 112918925(ASH1L) 112920160(KMT2A) 112921101(KMT2D) 112921783(SMYD2) 112923542(SMYD3) 112924552 112925373(KMT2E) 112928324(KMT2B) 112929256(SETD1A) 112934919(SETD7) 112935175(SETD1B)
AML: 100465228(KMT2C) 100466350(SMYD3) 100466490(SMYD2) 100468393(KMT2E) 100469094(KMT2B) 100469373(PRDM7) 100472168(SETD7) 100474237(ASH1L) 100478541(SETD1B) 100479447(KMT2D) 100482700(SETD1A) 100483766(SMYD1) 100484220(KMT2A) 109490334
UMR: 103657933(SETD1A) 103658074(SETD7) 103660985(KMT2C) 103661268(SETD1B) 103662507(KMT2A) 103666923(SMYD3) 103668369(ASH1L) 103671476(SMYD1) 103672523(SMYD2) 103673975(PRDM7) 103674714(KMT2E) 103675622(KMT2D) 103682560(KMT2B)
UAH: 113241427(KMT2C) 113242840(SMYD1) 113244759(KMT2B) 113245266(ASH1L) 113251646(PRDM7) 113255688(SETD7) 113257661(KMT2D) 113258804(KMT2E) 113259992(KMT2A) 113262691(SMYD2) 113262946(SMYD3) 113266937(SETD1B) 113267709(SETD1A)
ORO: 101362332(KMT2E) 101362407(SETD1B) 101362745(ASH1L) 101363392 101363669(KMT2A) 101364358(SMYD1) 101365628(KMT2C) 101368440(SETD7) 101369213(KMT2D) 101370290(KMT2B) 101371861(SMYD2) 101376995(SETD1A) 101383043(PRDM7) 101384991(SMYD3)
FCA: 101081435(SMYD2) 101084095(KMT2C) 101084945(KMT2E) 101085009(PRDM7) 101086114(ASH1L) 101089231(SMYD3) 101090288(KMT2A) 101091070(SETD1A) 101091191(SETD7) 101095247(SMYD1) 101095268(KMT2D) 101096419(SETD1B) 101098760(KMT2B)
PTG: 102949117(KMT2E) 102949463(SMYD3) 102953445(SETD7) 102956940(KMT2A) 102962859(KMT2D) 102964154(KMT2C) 102964982(KMT2B) 102968240(SMYD2) 102969005(SETD1A) 102969379(ASH1L) 102970032(SMYD1) 102970685(SETD1B) 102971819(PRDM7)
PPAD: 109245496(PRDM7) 109249058(KMT2D) 109249505(SETD7) 109251114(SMYD3) 109251503(KMT2B) 109252401(KMT2C) 109254457(SMYD2) 109256230(ASH1L) 109258968(SETD1A) 109264245(SMYD1) 109268101(KMT2E) 109277797(SETD1B) 109278556(KMT2A)
AJU: 106966460(KMT2A) 106966796(SMYD2) 106967594(SETD1B) 106968611(SMYD3) 106969329(KMT2D) 106974745(KMT2B) 106976180(SETD7) 106978140(SMYD1) 106978485(KMT2E) 106979084(SETD1A) 106981535(ASH1L) 106984461(KMT2C) 106985288(PRDM7)
BTA: 100139638 100190914(PRDM9) 100851938 506805(KMT2D) 508330(KMT2A) 514102(SETD1B) 515928(SETD7) 516002(PRDM7) 520584 537404(SMYD1) 539121(KMT2E) 540563(ASH1L) 615229(SMYD2) 616050(SMYD3) 782887(SETD1A) 785776(KMT2B) 789336(KMT2C)
BOM: 102267186(KMT2C) 102268887(KMT2D) 102269320(KMT2B) 102270977(SMYD1) 102271291 102273734(SMYD2) 102275046(ASH1L) 102279495(SETD1A) 102280025(KMT2A) 102280610(SETD1B) 102281278(KMT2E) 102281809(SETD7) 102282730 102287417(SMYD3)
BIU: 109553548(ASH1L) 109554959 109554963 109557366(KMT2E) 109558041(KMT2C) 109559148(KMT2D) 109561910 109566148(SMYD1) 109569413(KMT2A) 109570555(SMYD3) 109570591(SMYD2) 109570912(SETD1B) 109571070(SETD7) 109572325(KMT2B) 109578511(SETD1A)
BBUB: 102392548(SMYD3) 102393219(SETD1B) 102394548(SETD7) 102396938(KMT2C) 102398212(KMT2E) 102400596(KMT2B) 102401126(KMT2A) 102401677(SETD1A) 102401706(KMT2D) 102403578 102406655 102408066(SMYD1) 102413004 102415367(ASH1L) 102416088(SMYD2) 112582202 112582680 112582838
CHX: 102168698(KMT2D) 102169033(KMT2A) 102169548(KMT2E) 102170478(SETD1A) 102171177(SMYD3) 102172292(KMT2B) 102177044(PRDM9) 102179971(SETD1B) 102181925(KMT2C) 102183791(PRDM9) 102185413(ASH1L) 102185508 102187140(SMYD1) 102189783(SMYD2) 102191824(SETD7)
OAS: 101101875 101101916(KMT2A) 101102409(SMYD2) 101103509(SETD1B) 101103705 101104086(KMT2B) 101105467(SETD1A) 101108731(SMYD1) 101115617(KMT2C) 101115990(SETD7) 101116161(SMYD3) 101118592 101119775(ASH1L) 101120741(KMT2D) 101120895 101121766(KMT2E) 114116628
SSC: 100155920(ASH1L) 100156137(SETD1B) 100294702(SMYD1) 100294706(SMYD2) 100294707(SMYD3) 100511747(SETD1A) 100514805(KMT2C) 100520742(KMT2B) 100620538(PRDM7) 100623006(KMT2A) 100626704(SETD7) 100628131(KMT2E) 110260656(KMT2D)
CFR: 102506865(SETD7) 102507730(KMT2C) 102509980(SETD1A) 102510314(PRDM7) 102510601(ASH1L) 102513005(SMYD1) 102514543(KMT2E) 102514741(SMYD3) 102515223(KMT2D) 102515785(SMYD2) 102517824(KMT2A) 102520520(KMT2B) 102521372(SETD1B) 102523091 106728486
CDK: 105087090(SETD7) 105088051 105088782(ASH1L) 105090168(KMT2A) 105093021(KMT2E) 105098689(KMT2C) 105099293(SMYD2) 105099491(SMYD3) 105102557(SETD1B) 105102789(SETD1A) 105103813(KMT2D) 105104177(SMYD1) 105106131(PRDM7) 116154616
BACU: 103002011(KMT2E) 103002269(SETD7) 103004413(KMT2D) 103004433(KMT2C) 103008957(SETD1A) 103010622(SETD1B) 103014183(KMT2A) 103015601(KMT2B) 103015822(ASH1L) 103018045(SMYD3) 103018379(SMYD1) 103018911(PRDM7) 103020103(SMYD2)
LVE: 103068531(KMT2A) 103070332(SMYD1) 103071598(SETD7) 103073652(KMT2B) 103074842(KMT2E) 103077679(SETD1B) 103078348(KMT2C) 103079757(SETD1A) 103081140(SMYD3) 103082116(KMT2D) 103083457(PRDM7) 103084369 103087473(ASH1L) 103090372(SMYD2)
OOR: 101269640(KMT2D) 101271862(SMYD2) 101276223(KMT2B) 101278571(KMT2A) 101278914(SETD1B) 101281657(SMYD3) 101282114(SETD7) 101283071(SETD1A) 101284649(SMYD1) 101285642(KMT2E) 101288516(KMT2C) 101288541(ASH1L) 101290159(PRDM7)
DLE: 111164613(KMT2E) 111165396(SMYD1) 111166868(KMT2A) 111167169(ASH1L) 111174034(KMT2D) 111176572(KMT2C) 111177545(SMYD3) 111179118(SETD7) 111179685(PRDM7) 111181136(KMT2B) 111182119(SETD1A) 111184680(SMYD2) 111186875(SETD1B)
PCAD: 102974760(PRDM7) 102977910(SETD1B) 102980726(KMT2E) 102980789(SMYD1) 102981445(KMT2A) 102981848(KMT2D) 102986025(SETD7) 102987727(KMT2B) 102988929(KMT2C) 102989011(SMYD3) 102992344(SMYD2) 102992941(SETD1A) 102993773(ASH1L) 112064829 114487551
ECB: 100052774(SMYD2) 100052805(SMYD1) 100053168(PRDM7) 100057386(ASH1L) 100058928(KMT2E) 100058932(KMT2D) 100059267(SMYD3) 100059802(KMT2B) 100063257(SETD7) 100063523(SETD1A) 100064812(KMT2C) 100071238(KMT2A) 100146430(SETD1B)
EPZ: 103541678(SETD1B) 103545551 103546689(KMT2A) 103547270(SETD1A) 103547761(SMYD2) 103548807 103549975(SMYD1) 103551020(SETD7) 103552202(KMT2D) 103552840 103553137(KMT2C) 103560579(KMT2E) 103562021 103566091(KMT2B) 103566688 103567807(PRDM7)
EAI: 106823334(KMT2C) 106825187(KMT2E) 106828486(ASH1L) 106829152(KMT2B) 106831838(SETD1A) 106836860(KMT2D) 106838574(SMYD1) 106838612(SETD7) 106840333(KMT2A) 106842219(SETD1B) 106846818(SMYD2) 106846844(SMYD3)
MYB: 102240554 102244915(SMYD2) 102244965(KMT2D) 102246410(KMT2E) 102246482(SETD7) 102246704(KMT2C) 102246785(KMT2A) 102247786(SMYD3) 102253255(SETD1A) 102255512(SETD1B) 102255643 102256394(ASH1L) 102257900 102258373 102259087(KMT2B) 102262117
MYD: 102751347(SETD1B) 102755932(SMYD1) 102756071(SETD1A) 102758785(KMT2E) 102759674(KMT2C) 102760166(SETD7) 102760582(SMYD2) 102762410(KMT2D) 102764796(ASH1L) 102765569 102766910(KMT2A) 102769466(SMYD3) 102771251(KMT2B) 102774259 107182758
MNA: 107524895(KMT2C) 107524924 107528109(KMT2D) 107528337(SMYD3) 107528646(SMYD1) 107530776 107530799 107534917(SETD7) 107539362 107540799(SETD1A) 107541833(SETD1B) 107542284(KMT2E) 107542826 107543372(KMT2B) 107543779(ASH1L) 107546243(SMYD2)
HAI: 109371387 109372008(KMT2B) 109374193(SETD1A) 109376837(SMYD1) 109378226 109378400 109378707 109378765 109379108(SMYD2) 109381405(PRDM7) 109385301(KMT2A) 109386061(SETD1B) 109389650(KMT2C) 109391450 109392049(KMT2E) 109393224(KMT2D) 109393386(ASH1L) 109394201(SETD7)
DRO: 112296748(PRDM7) 112297714(SMYD2) 112301980 112303106(SMYD1) 112303206(KMT2E) 112303918 112303963 112304818(SETD1A) 112308262(KMT2C) 112310608(SETD1B) 112312687(SETD7) 112313830 112314381(KMT2A) 112316652 112316914(ASH1L) 112318232(KMT2D) 112318753(SMYD3) 112320053(KMT2B)
PALE: 102878419(PRDM7) 102879153(SETD1B) 102880671(SMYD1) 102881431(KMT2B) 102883630(SMYD2) 102884674(SETD1A) 102887843(SMYD3) 102888124(ASH1L) 102888384(KMT2E) 102888593(KMT2D) 102889824(PRDM9) 102890289(SETD7) 102893336(KMT2A) 102897550(KMT2C)
RAY: 107497624(KMT2B) 107498661(SMYD3) 107502258(KMT2A) 107503985(SETD1A) 107505913(SMYD1) 107508545 107511501(KMT2E) 107514237(KMT2D) 107515234(SETD1B) 107515339(SETD7) 107516247(PRDM9) 107520298(KMT2C) 107521457(ASH1L) 107521612 107521638(SMYD2)
LAV: 100653681(KMT2A) 100653839(SETD7) 100659534(SMYD3) 100660034(PRDM7) 100662609(SETD1A) 100664734 100666322(PRDM9) 100668468(ASH1L) 100668488(SETD1B) 100669611(KMT2B) 100670013(KMT2D) 100671071(KMT2E) 100672564(SMYD1) 100673765(KMT2C) 100674556(SMYD2) 100676686
MDO: 100013387(SETD1A) 100017118(ASH1L) 100018480(KMT2E) 100019161(KMT2C) 100023305(SMYD2) 100027436(SETD7) 100029674(SMYD1) 100031440(KMT2A) 100617561(KMT2B) 100618514(SETD1B) 100619798(SMYD3) 103099827(KMT2D)
SHR: 100916165(SMYD1) 100920575(KMT2C) 100922144(KMT2E) 100923245 100924557(KMT2A) 100926753 100927672(KMT2B) 100928096(SETD1B) 100928575(KMT2D) 100929261(SETD7) 100929291(SETD1A) 100931585(ASH1L) 100932883(SMYD3) 100934440(SMYD2) 105749741
PCW: 110194047(KMT2D) 110194897(SETD7) 110196348(SMYD1) 110196787(SETD1B) 110201341(KMT2B) 110201406(PRDM9) 110205493(SMYD3) 110206991(KMT2E) 110207193(KMT2A) 110211945(ASH1L) 110222694(SMYD2) 110223143(SETD1A) 110223876(KMT2C)
OAA: 100074286(KMT2C) 100074411(SETD1B) 100077208(KMT2E) 100078649(SMYD1) 100079176(SMYD2) 100081674(SETD7) 100082753(SMYD3) 100086068(KMT2A) 100090957(SETD1A) 103165316(KMT2B) 103168045(ASH1L)
GGA: 373960(SMYD1) 414897(KMT2A) 416851(SETD1B) 417712(KMT2E) 420437(KMT2C) 421361(SMYD2) 421489(SMYD3) 422443(SETD7) 425064(ASH1L) 425846(KMT2D)
MGP: 100538978(SMYD2) 100539732(ASH1L) 100540662(KMT2A) 100541967(SETD7) 100544670(SETD1B) 100545169(KMT2C) 100545555(KMT2E) 100548953(SMYD1) 104909329 104915798
CJO: 107308762(KMT2C) 107311083(SMYD2) 107311243(SMYD3) 107313101(SETD7) 107314020(SMYD1) 107321274(SETD1B) 107324133(KMT2A) 107324503(ASH1L) 107325180(KMT2E) 107325738(KMT2D)
NMEL: 110387546(KMT2A) 110387902(ASH1L) 110389135(KMT2D) 110392363(KMT2E) 110393789(KMT2C) 110395863(SMYD3) 110396134(SMYD2) 110397503(SETD7) 110398544(SMYD1) 110406578(SETD1B)
APLA: 101790791(SMYD2) 101796266(KMT2C) 101797321(KMT2A) 101800254(SETD7) 101800831(SMYD1) 101801343(SMYD3) 101803072(SETD1B) 101805084(KMT2E)
ACYG: 106031413(SETD1B) 106031578(SMYD2) 106033933(SMYD1) 106039772(KMT2A) 106040965(SETD7) 106043274(KMT2E) 106046952(KMT2C) 106047718(KMT2D) 106048498(ASH1L) 106049693(SMYD3)
TGU: 100219723(SMYD3) 100219994(SETD7) 100225647(SETD1B) 100226399(KMT2E) 100226907(KMT2D) 100227193(KMT2C) 100229714(ASH1L) 100230154(SMYD1) 100230503(SMYD2) 100231049(KMT2A)
LSR: 110468513(SETD7) 110470458(KMT2A) 110471483(ASH1L) 110471750(SETD1B) 110472726(KMT2E) 110473308(SMYD1) 110479948(SMYD2) 110480395(KMT2D) 110481707(SMYD3) 110484559(KMT2C)
SCAN: 103813061(KMT2C) 103813524(KMT2E) 103817699(SMYD3) 103818319(SETD1B) 103821549(SMYD2) 103822533(SETD7) 103822784(KMT2A) 103823501(SMYD1) 103823951(ASH1L) 103824625(KMT2D)
GFR: 102031396(KMT2C) 102032923(SMYD2) 102034037(KMT2D) 102036439(KMT2A) 102037071(SMYD1) 102037758(SMYD3) 102040049(SETD1B) 102040515(SETD7) 102042927(ASH1L) 102045471(KMT2E) 106632190
FAB: 101806346(KMT2C) 101807006(SMYD2) 101807375(SETD7) 101812652(SETD1B) 101812878(KMT2E) 101813917(KMT2A) 101818086(KMT2D) 101819907(ASH1L) 101821319(SMYD3) 101822247(SMYD1)
PHI: 102099277(KMT2C) 102100454(KMT2D) 102101401(SMYD2) 102102416(SMYD1) 102103515(KMT2A) 102106186(SETD7) 102107307(SMYD3) 102108338(KMT2E) 102113028(ASH1L) 102114734(SETD1B) 106628993
PMAJ: 107198594(KMT2D) 107202071(SMYD2) 107202430(SMYD3) 107203381(SETD7) 107203527(SMYD1) 107204272(KMT2E) 107211664(SETD1B) 107214385(KMT2A) 107214568(ASH1L) 107216349(KMT2C)
CCAE: 111923252(KMT2E) 111925501(KMT2C) 111926193(SMYD2) 111926986 111927591 111928311(SMYD1) 111928908(SETD7) 111936709(SETD1B) 111939213(KMT2A) 111939443(ASH1L) 111940566
CCW: 104683547(ASH1L) 104684478(SMYD3) 104685633(SMYD2) 104686428(KMT2C) 104686872(KMT2E) 104688830(SETD1B) 104690813(SMYD1) 104692048(KMT2A) 104697344(SETD7)
ETL: 114055005(SETD1B) 114056306(KMT2A) 114058383(SETD7) 114060528(KMT2E) 114060897(SMYD2) 114062389(KMT2C) 114065339(SMYD3) 114066019 114067206(SMYD1) 114069574(ASH1L) 114071069(KMT2D) 114072229 114073002
FPG: 101911864(SETD1B) 101913546(ASH1L) 101916525(KMT2D) 101917176(KMT2C) 101917301(SETD7) 101919056(SMYD1) 101919125(SMYD3) 101919912(KMT2E) 101922729(KMT2A) 101923412(SMYD2)
FCH: 102047191(KMT2C) 102047542(KMT2E) 102049111 102051296(SETD1B) 102053523(SETD7) 102056587(ASH1L) 102057033(SMYD1) 102057924(SMYD2) 102058880(SMYD3) 102059401(KMT2A)
CLV: 102083945(SETD1B) 102084453(KMT2A) 102086496(SMYD1) 102087865(SETD7) 102088613(SMYD2) 102088903(KMT2E) 102090928(ASH1L) 102091442(KMT2D) 102092665(SMYD3) 102097963(KMT2C)
EGZ: 104122745(SETD1B) 104123317 104126982(SMYD1) 104128583(KMT2E) 104130998(KMT2C) 104131533(SMYD3) 104132856(SMYD2) 104134673(SETD7) 104134854(ASH1L) 104135262 104135361(KMT2A)
NNI: 104010731(KMT2E) 104011458(SMYD3) 104014894(KMT2C) 104015980(SETD7) 104016208(KMT2A) 104017938 104018532(SMYD1) 104019711(SMYD2) 104020487(ASH1L) 104020788(SETD1B)
ACUN: 113477175(KMT2C) 113477910(SMYD3) 113478725(SMYD2) 113479169(SMYD1) 113479515(SETD7) 113485968(SETD1B) 113488577(KMT2A) 113488743(ASH1L) 113490163(KMT2E)
PADL: 103913294(ASH1L) 103914561(SETD1B) 103914598(SMYD3) 103915639(KMT2C) 103916551(KMT2A) 103920580(KMT2E) 103920974(SETD7) 103922130(SMYD2) 103923505(SMYD1)
AAM: 106484901(SMYD1) 106485191(KMT2A) 106485306(KMT2C) 106485538(SMYD3) 106485892(KMT2E) 106490428(SMYD2) 106491857(SETD7) 106494341(ASH1L) 106495668(SETD1B) 106497500(KMT2D)
ASN: 102368053(SMYD1) 102372997(ASH1L) 102373099(KMT2D) 102374512(SETD7) 102375642(KMT2E) 102378568(SETD1B) 102379342(KMT2C) 102381556(SMYD3) 102382195(KMT2B) 102383161(SMYD2) 102385246(KMT2A) 102387237(SETD1A)
AMJ: 102560006(KMT2D) 102560388(KMT2E) 102567474(KMT2C) 102568755(SETD7) 102571713(ASH1L) 102571979 102572253(KMT2A) 102574091(SETD1B) 102575326(SMYD2) 102575695(SMYD1) 102576362(SMYD3) 102576444(SETD1A) 106739435 109281961
PSS: 102445204 102446823 102448089(SETD1B) 102448117(ASH1L) 102449156(SMYD1) 102450509(KMT2D) 102454598(KMT2E) 102455968 102456582(SMYD3) 102459016(KMT2C) 102460627 102460633(SETD1A) 102461265(SMYD2) 102461649(SETD7) 102463628(KMT2A)
CMY: 102931937(KMT2B) 102932627 102933355(KMT2E) 102933435(SMYD2) 102934693(SETD1B) 102936055(SMYD1) 102937004(SETD1A) 102937036(SMYD3) 102941272(KMT2A) 102943205(SETD7) 102943662(ASH1L) 102944171 102948345(KMT2C)
CPIC: 101930966(SETD7) 101934288(KMT2D) 101934563 101935009(KMT2E) 101936901(SETD1A) 101939661(SETD1B) 101939705 101941687(KMT2A) 101942050(ASH1L) 101947848 101948178(SMYD2) 101950574(KMT2B) 101951595(SMYD1) 101951981(SMYD3) 101953918(KMT2C)
ACS: 100551939(setd7) 100553183(kmt2e) 100554175(kmt2d) 100556055(kmt2c) 100556600(kmt2b) 100557667(smyd2) 100560745(kmt2a) 100561699(smyd1) 100563888(ash1l) 103279564(setd1a) 103279992 103280931(setd1b) 107982259
PVT: 110071916(KMT2C) 110073660(SETD7) 110075080(KMT2D) 110076069(SMYD3) 110079453(KMT2A) 110080953(KMT2E) 110081037(ASH1L) 110083882(SETD1B) 110086348(SMYD1) 110086418(SETD1A) 110086747 110087176(SMYD2) 110089900(KMT2B)
PBI: 103049419 103051289(KMT2D) 103051962(KMT2E) 103052345(SMYD3) 103054198(SMYD2) 103054534(SETD1A) 103055134(PRDM9) 103056555(SETD7) 103058624(SMYD1) 103058696(KMT2B) 103060233(ASH1L) 103063162(SETD1B) 103065683 103067762(KMT2A)
PMUR: 107284778(KMT2A) 107286389(KMT2D) 107286731 107286738 107286983(SETD1B) 107287999(KMT2B) 107289289(SMYD2) 107289708 107290222(SETD1A) 107292628 107293153(SETD7) 107297020(ASH1L) 107298635(KMT2E) 107301328 107302384(SMYD1) 107303312(KMT2C)
PMUA: 114582254(SMYD1) 114582823(SETD1A) 114585722(KMT2A) 114586200(SETD1B) 114586229(ASH1L) 114587663 114594456(SMYD3) 114594675(SMYD2) 114603572(KMT2B) 114604135(SETD7) 114605818(KMT2E) 114607001(KMT2C)
GJA: 107105569(SMYD1) 107105838(KMT2D) 107106655(SETD1A) 107106688 107108065(SMYD3) 107108169(KMT2B) 107109138 107110772(SETD7) 107112539(KMT2A) 107113725(KMT2E) 107115893(SETD1B) 107119617(ASH1L) 107121665(SMYD2) 107123156 107123162(KMT2C)
XTR: 100135006(kmt2a) 100144721(kmt2b) 100145429(smyd1) 100486829(kmt2c) 100487270(setd1a) 100494109(kmt2d) 100494527(smyd3) 100495522(smyd2) 613102(setd7) 779539(kmt2e) 780106(setd1b)
NPR: 108783805(SMYD2) 108784343(KMT2C) 108787262(SETD1B) 108787486(SMYD3) 108787523(SETD7) 108791395(KMT2D) 108794233(ASH1L) 108794984(KMT2A) 108795231(KMT2E) 108796886(SMYD1) 108799776(KMT2B) 108800988(SETD1A)
DRE: 100536523(kmt2d) 321245(smyd1a) 325395(kmt2e) 393876(prdm9) 436729(setd7) 541423(smyd2a) 556535(setd1a) 557048(kmt2a) 560793(kmt2ca) 560856(kmt2ba) 563799(ash1l) 566825(kmt2bb) 567970(setd1ba) 568616(smyd2b) 569027(smyd1b) 569507(smyd3) 571274(setd1bb)
NFU: 107372442(kmt2b) 107373342(setd1b) 107374212 107375014(smyd1) 107377597(smyd2) 107378515(setd1a) 107379592(ash1l) 107380358(kmt2a) 107381186 107381206(smyd3) 107383945(kmt2c) 107386366(kmt2e) 107387053(setd7) 107387683(znf286a) 107390885(kmt2d) 107393824 107393825 107394125 107394561 107394636
LCM: 102347272(KMT2C) 102349685(SMYD1) 102349988(KMT2E) 102350182(SETD7) 102351078(SETD1A) 102354014(KMT2D) 102354331 102354519(SMYD2) 102354605 102357046(KMT2A) 102357625 102361515(SMYD3) 102363172(SETD1B) 102367246(ASH1L)
CMK: 103172000 103176975(kmt2e) 103180354(kmt2a) 103181297(setd7) 103181513(smyd1) 103181738(smyd3) 103184390(setd1b) 103186165(smyd2) 103189259(kmt2d) 103189435(kmt2c) 103189436 103191129
DME: Dmel_CG13761(Smyd3) Dmel_CG3848(trr) Dmel_CG40351(Set1) Dmel_CG8651(trx) Dmel_CG8887(ash1)
DSI: Dsimw501_GD11928(Dsim_GD11928) Dsimw501_GD12268(Dsim_GD12268) Dsimw501_GD16408(Dsim_GD16408) Dsimw501_GD20433(Dsim_GD20433) Dsimw501_GD28104(Dsim_GD28104) Dsimw501_GD29063(Dsim_GD29063)
CEL: CELE_C26E6.9(set-2) CELE_R06F6.4(set-14) CELE_T12D8.1(set-16) CELE_T12F5.4(lin-59) CELE_T22A3.4(set-18) CELE_ZC8.3(set-30)
CBR: CBG03016(Cbr-set-14) CBG12017(Cbr-lin-59) CBG14580(Cbr-set-30) CBG18244(Cbr-set-16) CBG24752(Cbr-set-18)
ATH: AT1G43245 AT2G17900(SDG37) AT2G19640(ASHR2) AT4G15180(SDG2) AT5G06620(SDG38)
LJA: Lj0g3v0111689.1(Lj0g3v0111689.1) Lj0g3v0111689.2(Lj0g3v0111689.2) Lj0g3v0252639.1(Lj0g3v0252639.1) Lj0g3v0252639.2(Lj0g3v0252639.2) Lj0g3v0308279.1(Lj0g3v0308279.1) Lj0g3v0308279.2(Lj0g3v0308279.2) Lj0g3v0308279.3(Lj0g3v0308279.3) Lj1g3v0764540.1(Lj1g3v0764540.1) Lj1g3v0764540.2(Lj1g3v0764540.2) Lj2g3v2985910.1(Lj2g3v2985910.1) Lj2g3v2985910.2(Lj2g3v2985910.2) Lj2g3v2985910.3(Lj2g3v2985910.3) Lj3g3v2888370.1(Lj3g3v2888370.1) Lj3g3v2888370.2(Lj3g3v2888370.2) Lj4g3v0165060.1(Lj4g3v0165060.1) Lj4g3v0166140.1(Lj4g3v0166140.1)
DOSA: Os03t0704200-01(Os03g0704200) Os04t0423600-01(Os04g0423600) Os08t0180100-01(Os08g0180100) Os08t0205300-01(Os08g0205300) Os10t0410700-01(Os10g0410700)
ATS: 109736528(LOC109736528) 109741969(LOC109741969) 109747984(LOC109747984) 109776439(LOC109776439) 109778416(LOC109778416)
OLU: OSTLU_15174(SDG3512) OSTLU_32372(SDG3514) OSTLU_88595(SDG3527) OSTLU_92854(SDG3513)
SCE: YHR119W(SET1)
KMX: KLMA_30450(SET6) KLMA_60252(SET1)
NCS: NCAS_0B07030(NCAS0B07030) NCAS_0C01270(NCAS0C01270)
NDI: NDAI_0B04360(NDAI0B04360) NDAI_0K01280(NDAI0K01280)
TPF: TPHA_0I01480(TPHA0I01480)
TBL: TBLA_0C05500(TBLA0C05500)
TDL: TDEL_0A06370(TDEL0A06370) TDEL_0B05100(TDEL0B05100)
KAF: KAFR_0F00700(KAFR0F00700) KAFR_0H02340(KAFR0H02340)
SLB: AWJ20_424(SET6) AWJ20_608(SET1)
NCR: NCU01206(set-1) NCU01932(set-3) NCU02962
NTE: NEUTE1DRAFT125465(NEUTE1DRAFT_125465) NEUTE1DRAFT144212(NEUTE1DRAFT_144212) NEUTE1DRAFT150707(NEUTE1DRAFT_150707)
NHE: NECHADRAFT_123121(SDG2103) NECHADRAFT_123247(SDG2115) NECHADRAFT_49470(SDG2101) NECHADRAFT_74600(SDG2107)
ANG: ANI_1_1490164(An18g06840) ANI_1_1754144(An16g04950) ANI_1_2518094(An11g09860)
PBN: PADG_03985 PADG_06078 PADG_11427(PADG_02444)
SPO: SPBP8B7.07c(set6) SPCC306.04c(set1)
CNE: CND03610
CNB: CNBD2720
ABP: AGABI1DRAFT102088(AGABI1DRAFT_102088) AGABI1DRAFT120631(AGABI1DRAFT_120631) AGABI1DRAFT41599(AGABI1DRAFT_41599) AGABI1DRAFT76762(AGABI1DRAFT_76762)
ABV: AGABI2DRAFT120820(AGABI2DRAFT_120820) AGABI2DRAFT209673(AGABI2DRAFT_209673) AGABI2DRAFT211045(AGABI2DRAFT_211045) AGABI2DRAFT223832(AGABI2DRAFT_223832)
EHI: EHI_092690(175.t00011)
PYO: PY17X_1133200(PY04885)
PCB: PCHAS_113130(PC000913.02.0)
CPV: cgd7_5090
SMIN: v1.2.013565.t1(symbB.v1.2.013565.t1) v1.2.019699.t1(symbB.v1.2.019699.t1) v1.2.029529.t3(symbB.v1.2.029529.t3) v1.2.035053.t1(symbB.v1.2.035053.t1)
 » show all
Taxonomy
Reference
1  [PMID:12453419]
  Authors
Nakamura T, Mori T, Tada S, Krajewski W, Rozovskaia T, Wassell R, Dubois G, Mazo A, Croce CM, Canaani E
  Title
ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation.
  Journal
Mol Cell 10:1119-28 (2002)
  Sequence
[hsa:4297]
Reference
2  [PMID:12540855]
  Authors
Xiao B, Jing C, Wilson JR, Walker PA, Vasisht N, Kelly G, Howell S, Taylor IA, Blackburn GM, Gamblin SJ
  Title
Structure and catalytic mechanism of the human histone methyltransferase SET7/9.
  Journal
Nature 421:652-6 (2003)
DOI:10.1038/nature01378
  Sequence
[hsa:80854]
Reference
3  [PMID:15235609]
  Authors
Hamamoto R, Furukawa Y, Morita M, Iimura Y, Silva FP, Li M, Yagyu R, Nakamura Y
  Title
SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells.
  Journal
Nat Cell Biol 6:731-40 (2004)
DOI:10.1038/ncb1151
  Sequence
[hsa:64754]
Reference
4  [PMID:27129774]
  Authors
Blazer LL, Lima-Fernandes E, Gibson E, Eram MS, Loppnau P, Arrowsmith CH, Schapira M, Vedadi M
  Title
PR Domain-containing Protein 7 (PRDM7) Is a Histone 3 Lysine 4 Trimethyltransferase.
  Journal
J Biol Chem 291:13509-19 (2016)
  Sequence
[hsa:11105]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.354
IUBMB Enzyme Nomenclature: 2.1.1.354
ExPASy - ENZYME nomenclature database: 2.1.1.354
BRENDA, the Enzyme Database: 2.1.1.354
LinkDB All DBs

DBGET integrated database retrieval system