EC                Enzyme                                 

[histone H4]-N-methyl-L-lysine20 N-methyltransferase;
KMT5B (gene name);
KMT5C (gene name);
SUV420H1 (gene name);
SUV420H2 (gene name)
Transferring one-carbon groups;
S-adenosyl-L-methionine:[histone H4]-N6-methyl-L-lysine20 N6-methyltransferase
S-adenosyl-L-methionine + a [histone H4]-N6-methyl-L-lysine20 = S-adenosyl-L-homocysteine + a [histone H4]-N6,N6-dimethyl-L-lysine20
(other) R04866
S-adenosyl-L-methionine [CPD:C00019];
[histone H4]-N6-methyl-L-lysine20
S-adenosyl-L-homocysteine [CPD:C00021];
[histone H4]-N6,N6-dimethyl-L-lysine20
This entry describes a group of enzymes that catalyse a single methylation of monomethylated lysine20 of histone H4 (H4K20m1, generated by EC, [histone H4]-lysine20 N-methyltransferase), forming the dimethylated form. This modification is broadly distributed across the genome and is likely important for general chromatin-mediated processes. The double-methylated form of lysine20 in histone H4 is the most abundant methylation state of this residue and is found on ~80% of all histone H4 molecules. Full activity of the enzyme requires that the lysine at position 9 of histone H3 is trimethylated.
EC created 1976 as EC, modified 1982, modified 1983, part transferred 2019 to EC
ec00310  Lysine degradation
ec01100  Metabolic pathways
K11429  [histone H4]-N-methyl-L-lysine20 N-methyltransferase
HSA: 51111(KMT5B) 84787(KMT5C)
PTR: 451378(KMT5B) 735868(KMT5C)
PPS: 100984020(KMT5C) 100995372(KMT5B)
GGO: 101139439(KMT5C) 101151252(KMT5B)
PON: 100450271(KMT5B) 100450936(KMT5C)
NLE: 100583977(KMT5B) 100599527(KMT5C)
MCC: 699963(KMT5C) 710481(KMT5B)
MCF: 102117388(KMT5B) 102129054(KMT5C)
CSAB: 103215291(KMT5B) 103235303(KMT5C)
RRO: 104664716(KMT5B) 104674764(KMT5C)
RBB: 108518702(KMT5B) 108542541(KMT5C)
CJC: 100393036(KMT5C) 100400804(KMT5B)
SBQ: 101047990(SUV420H2) 101053072(SUV420H1)
MMU: 225888(Kmt5b) 232811(Kmt5c)
MCAL: 110285500(Kmt5b) 110298763(Kmt5c)
MPAH: 110334213(Kmt5b) 110336454(Kmt5c)
RNO: 308345(Kmt5c) 361688(Kmt5b)
MUN: 110547082(Kmt5b) 110561067(Kmt5c)
CGE: 100761878(Kmt5b) 100772952(Kmt5c)
NGI: 103744517(Kmt5b) 103744814(Kmt5c)
HGL: 101707567(Kmt5c) 101719039(Kmt5b)
CCAN: 109692079(Kmt5b) 109696272(Kmt5c)
OCU: 100340037(KMT5B)
TUP: 102474475 102497986(KMT5B) 102499452(KMT5C)
CFA: 483690(KMT5B) 484295(KMT5C)
VVP: 112909339(KMT5C) 112924166(KMT5B)
AML: 100468595(KMT5B) 100478438(KMT5C)
UMR: 103679527 103680304(KMT5C)
UAH: 113244004(KMT5B) 113247443(KMT5C)
ORO: 101374708(SUV420H2) 101375610(SUV420H1)
FCA: 101091322(KMT5C) 101094702(KMT5B)
PTG: 102953097(KMT5C) 102963329(KMT5B)
PPAD: 109246874(KMT5B) 109259888(KMT5C)
AJU: 106971172(KMT5B) 106980935(KMT5C)
BTA: 519777(KMT5C) 767828(KMT5B)
BOM: 102268312(KMT5B) 102288327(KMT5C)
BIU: 109572897(KMT5C)
BBUB: 102390793(KMT5C) 102405866(KMT5B)
CHX: 102185214(KMT5C) 102185720(KMT5B)
OAS: 101111001 101121289(KMT5C) 101121812(KMT5B)
SSC: 100521358(KMT5B) 110261054(KMT5C)
CFR: 102520054(KMT5B) 116666001(KMT5C)
CDK: 105098743(KMT5C) 105104405(KMT5B)
BACU: 102997321(KMT5C) 103007228(KMT5B)
LVE: 103090973(KMT5C) 103091082(KMT5B)
OOR: 101269348(SUV420H2) 101270232(SUV420H1)
DLE: 111181001(KMT5C) 111183648(KMT5B)
PCAD: 102982740(KMT5C) 102994432(KMT5B)
ECB: 100053438(KMT5B) 100055743(KMT5C)
EPZ: 103551272(KMT5B) 103562880(KMT5C)
EAI: 106840934(KMT5C) 106844276(KMT5B)
MYB: 102257692(KMT5B)
MYD: 102762755(KMT5B)
MNA: 107537430(KMT5B) 107541336(KMT5C)
HAI: 109373782(KMT5C) 109389302(KMT5B)
DRO: 112313746(KMT5C) 112317051(KMT5B)
PALE: 102887326(KMT5B) 102887846(KMT5C)
RAY: 107503474(KMT5B) 107515406(KMT5C)
MJV: 108388709(KMT5C) 108405830(KMT5B)
LAV: 100671600(KMT5B) 100671832(KMT5C)
MDO: 100010281(KMT5B)
SHR: 100917457(KMT5B)
PCW: 110195350(KMT5B) 110219937(KMT5C)
OAA: 100088070(KMT5B) 114814778(KMT5C)
GGA: 101748081(KMT5C) 425119(KMT5B)
MGP: 100547012(KMT5B) 116217397
CJO: 107307235(KMT5C) 107314523(KMT5B)
NMEL: 110391343(KMT5C) 110401096(KMT5B)
APLA: 101803754(KMT5B)
ACYG: 106038840(SUV420H1)
TGU: 100222904(KMT5B)
LSR: 110484490(KMT5B)
SCAN: 103824088(KMT5B)
GFR: 102041210(KMT5B)
FAB: 101805731(KMT5B)
PHI: 102102011(KMT5B) 102106962(KMT5C)
PMAJ: 107205911(KMT5B)
CCAE: 111930710(KMT5B)
CCW: 104692390(KMT5B)
ETL: 114064814(KMT5B)
FPG: 101921673(KMT5B)
FCH: 102046441(KMT5B)
CLV: 102091143(KMT5B)
EGZ: 104132445(SUV420H1)
NNI: 104017300(SUV420H1)
ACUN: 113481137(KMT5B)
PADL: 103919876(SUV420H1)
AAM: 106494851 106494860(KMT5B)
ASN: 102378990(KMT5C) 102379587(KMT5B)
AMJ: 102559156(KMT5C) 102568601(KMT5B)
PSS: 102456135(KMT5B)
CMY: 102946000(KMT5B)
CPIC: 101932218(KMT5C) 101950551(KMT5B)
ACS: 100553817(kmt5b) 100562840(suv420h2)
PVT: 110074171(KMT5B) 110078503(KMT5C)
PBI: 103053694(KMT5B) 103066601(KMT5C)
PMUR: 107282452(KMT5C) 107295878(KMT5B) 107296922
TSR: 106547726 106553569(SUV420H1)
PMUA: 114599913(KMT5B) 114608036(KMT5C)
GJA: 107118429(KMT5C) 107119069(KMT5B)
XLA: 108697809(kmt5c.S) 444204(kmt5b.S) 495826(kmt5b.L) 779432(kmt5c.L)
XTR: 100038141(kmt5b) 100145748(kmt5c)
NPR: 108784118(KMT5B) 108795144
DRE: 569041(kmt5c) 572849(kmt5b)
IPU: 108264420(suv420h1) 108271342 108280634
PHYP: 113534430(kmt5b) 113536364
AMEX: 103025343 103035158(kmt5b)
TRU: 101069597 101076428(kmt5b)
LCO: 104937792(kmt5b)
NCC: 104958752(suv420h1)
MZE: 101471827(kmt5b) 101477849
ONL: 100691614 100700783(kmt5b)
OLA: 101156070(kmt5b) 101165555
XMA: 102220708(kmt5b) 102236356
XCO: 114143669(kmt5b) 114159982
PRET: 103460097(kmt5b) 103468964
CVG: 107085059(kmt5b) 107096940
NFU: 107378497 107381531(kmt5b)
KMR: 108237783 108250521(kmt5b)
ALIM: 106532050(suv420h1)
AOCE: 111578621(kmt5b)
CSEM: 103379016(kmt5b)
POV: 109634192 109645819(kmt5b)
LCF: 108894245(kmt5b)
SDU: 111217719 111224033(kmt5b)
SLAL: 111656626(kmt5b) 111660544
HCQ: 109514373(kmt5b) 109527740
BPEC: 110168042(kmt5b)
MALB: 109951248(kmt5b) 109963137
ELS: 105023468 105029585(kmt5b)
SFM: 108934513(kmt5b) 108941728(kmt5c) 108942441
LCM: 102357247(KMT5C) 102357304(KMT5B)
CMK: 103174937(kmt5b) 103189530(kmt5c)
RTP: 109912567(kmt5b) 109932362
BFO: 118413910
CIN: 100186975
SPU: 583266
APLC: 110975028
SKO: 100372808
DME: Dmel_CG13363(Hmt4-20)
DER: 6555511
DSE: 6615887
DSI: Dsimw501_GD16466(Dsim_GD16466)
DSR: 110178198
DPE: 6600100
DMN: 108164669
DWI: 6644812
DAZ: 108618025
DNV: 108655611
DHE: 111596240
MDE: 101897840
LCQ: 111679605
AME: 411906
BIM: 100742553
BTER: 100644080
CCAL: 108624513
OBB: 114881313
SOC: 105195127
MPHA: 105830481
AEC: 105144221
ACEP: 105627042
PBAR: 105427527
VEM: 105568890
HST: 105183369
DQU: 106749629
CFO: 105255356
LHU: 105672756
PGC: 109853314
OBO: 105280691
PCF: 106793217
CSOL: 105362524
TCA: 663776
DPA: 109533054
ATD: 109597721
NVL: 108569827
BMOR: 101735557
BMAN: 114248506
PMAC: 106708893
PRAP: 110992850
HAW: 110372275
TNL: 113508300
PXY: 105397967
RMD: 113549136
BTAB: 109030108
CLEC: 106669134
ZNE: 110835364
TUT: 107371540
DPTE: 113794752
CSCU: 111636078
PTEP: 107455782
CEL: CELE_C32D5.5(set-4)
CBR: CBG02629(Cbr-set-4) CBG14502
BMY: Bm1_06250
PCAN: 112560425
CRG: 105319029
MYI: 110457084
OBI: 106875752
SHX: MS3_08308
EGL: EGR_03818
NVE: 5514661
EPA: 110245633
ADF: 107353716
AMIL: 114956880
PDAM: 113667740
SPIS: 111325445
DGT: 114533764
HMG: 100207998
QSU: 112005838
NCR: NCU08551
MGR: MGG_07393
SSCK: SPSK_07036
MAW: MAC_03332
MAJ: MAA_07113
CMT: CCM_08113
MBE: MBM_09131
ANI: AN6147.2
ANG: ANI_1_476104(An12g03880)
ABE: ARB_04917
TVE: TRV_05893
PTE: PTT_18535
CNE: CNC03710
TASA: A1Q1_07214
MGL: MGL_1066
MRT: MRET_3089
 » show all
1  [PMID:15145825]
Schotta G, Lachner M, Sarma K, Ebert A, Sengupta R, Reuter G, Reinberg D, Jenuwein T
A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin.
Genes Dev 18:1251-62 (2004)
2  [PMID:23345616]
Jorgensen S, Schotta G, Sorensen CS
Histone H4 lysine 20 methylation: key player in epigenetic regulation of genomic  integrity.
Nucleic Acids Res 41:2797-806 (2013)
3  [PMID:24396869]
Wu H, Siarheyeva A, Zeng H, Lam R, Dong A, Wu XH, Li Y, Schapira M, Vedadi M, Min J
Crystal structures of the human histone H4K20 methyltransferases SUV420H1 and SUV420H2.
FEBS Lett 587:3859-68 (2013)
[hsa:51111 84787]
4  [PMID:24049080]
Southall SM, Cronin NB, Wilson JR
A novel route to product specificity in the Suv4-20 family of histone H4K20 methyltransferases.
Nucleic Acids Res 42:661-71 (2014)
5  [PMID:27105552]
Weirich S, Kudithipudi S, Jeltsch A
Specificity of the SUV4-20H1 and SUV4-20H2 protein lysine methyltransferases and  methylation of novel substrates.
J Mol Biol 428:2344-2358 (2016)
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