KEGG   ENZYME: 2.1.1.364
Entry
EC 2.1.1.364                Enzyme                                 

Name
[histone H3]-lysine4 N-methyltransferase;
KMT7 (gene name);
SETD7 (gene name);
SET7/9 (gene name);
KIAA1717 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:[histone H3]-L-lysine4 N6-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + a [histone H3]-L-lysine4 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine4 [RN:R03875]
Reaction(KEGG)
R03875
Substrate
S-adenosyl-L-methionine [CPD:C00019];
[histone H3]-L-lysine4
Product
S-adenosyl-L-homocysteine [CPD:C00021];
[histone H3]-N6-methyl-L-lysine4
Comment
This entry describes enzymes that catalyse a single methylation of the L-lysine4 residue of histone H3 (H3K4), generating a monomethylated form. This modifications influence the binding of chromatin-associated proteins and result in gene activation or suppression. Some enzymes that catalyse this reaction continue to generate a trimethylated form; these enzymes are classified under EC 2.1.1.354, [histone H3]-lysine4 N-trimethyltransferase.
History
EC 2.1.1.364 created 1976 as EC 2.1.1.43, modified 1982, modified 1983, part transferred 2020 to EC 2.1.1.354
Pathway
ec00310  Lysine degradation
ec01100  Metabolic pathways
Orthology
K11431  [histone H3]-lysine4 N-methyltransferase
Genes
HSA: 80854(SETD7)
PTR: 737682(SETD7)
PPS: 100981554(SETD7)
GGO: 101136477(SETD7)
PON: 100449956(SETD7)
NLE: 100602353(SETD7)
MCC: 700426(SETD7)
MCF: 102140141(SETD7)
CSAB: 103236281(SETD7)
RRO: 104654337(SETD7)
RBB: 108522758(SETD7)
CJC: 100414241(SETD7)
SBQ: 101047679(SETD7)
MMU: 73251(Setd7)
MCAL: 110291535(Setd7)
MPAH: 110320364(Setd7)
RNO: 689954(Setd7)
MUN: 110545142(Setd7)
CGE: 100767175(Setd7)
NGI: 103742371(Setd7)
HGL: 101715832(Setd7)
CCAN: 109691464(Setd7)
OCU: 100347837(SETD7) 103347079
TUP: 102470517(SETD7)
CFA: 476079(SETD7)
VVP: 112934919(SETD7)
AML: 100472168(SETD7)
UMR: 103658074(SETD7)
UAH: 113255688(SETD7)
ORO: 101368440(SETD7)
ELK: 111149217
FCA: 101091191(SETD7)
PTG: 102953445(SETD7)
PPAD: 109249505(SETD7)
AJU: 106976180(SETD7)
BTA: 515928(SETD7)
BOM: 102281809(SETD7)
BIU: 109571070(SETD7)
BBUB: 102394548(SETD7)
CHX: 102191824(SETD7)
OAS: 101115990(SETD7) 114116628
SSC: 100626704(SETD7)
CFR: 102506865(SETD7)
CDK: 105087090(SETD7)
BACU: 103002269(SETD7)
LVE: 103071598(SETD7)
OOR: 101282114(SETD7)
DLE: 111179118(SETD7)
PCAD: 102986025(SETD7)
ECB: 100063257(SETD7)
EPZ: 103551020(SETD7)
EAI: 106838612(SETD7)
MYB: 102246482(SETD7)
MYD: 102760166(SETD7)
MNA: 107534917(SETD7)
HAI: 109394201(SETD7)
DRO: 112312687(SETD7)
PALE: 102890289(SETD7)
RAY: 107515339(SETD7)
MJV: 108408880(SETD7)
LAV: 100653839(SETD7)
TMU: 101344981
MDO: 100027436(SETD7)
SHR: 100929261(SETD7)
PCW: 110194897(SETD7)
OAA: 100081674(SETD7)
GGA: 422443(SETD7)
MGP: 100541967(SETD7)
CJO: 107313101(SETD7)
NMEL: 110397503(SETD7)
APLA: 101800254(SETD7)
ACYG: 106040965(SETD7)
TGU: 100219994(SETD7)
LSR: 110468513(SETD7)
SCAN: 103822533(SETD7)
GFR: 102040515(SETD7)
FAB: 101807375(SETD7)
PHI: 102106186(SETD7)
PMAJ: 107203381(SETD7)
CCAE: 111928908(SETD7)
CCW: 104697344(SETD7)
ETL: 114058383(SETD7)
FPG: 101917301(SETD7)
FCH: 102053523(SETD7)
CLV: 102087865(SETD7)
EGZ: 104134673(SETD7)
NNI: 104015980(SETD7)
ACUN: 113479515(SETD7)
PADL: 103920974(SETD7)
AAM: 106491857(SETD7)
ASN: 102374512(SETD7)
AMJ: 102568755(SETD7)
PSS: 102461649(SETD7)
CMY: 102943205(SETD7)
CPIC: 101930966(SETD7)
ACS: 100551939(setd7)
PVT: 110073660(SETD7)
PBI: 103056555(SETD7)
PMUR: 107293153(SETD7)
TSR: 106552387(SETD7)
PMUA: 114604135(SETD7)
GJA: 107110772(SETD7)
XLA: 108699643(setd7.L)
XTR: 613102(setd7)
NPR: 108787523(SETD7)
DRE: 436729(setd7)
SRX: 107756477(setd7)
SGH: 107550878(setd7)
IPU: 108268872(setd7)
PHYP: 113542848(setd7)
AMEX: 103021629(setd7)
EEE: 113581529(setd7)
TRU: 101062805(setd7)
LCO: 104921509(setd7)
MZE: 101473334(setd7)
ONL: 100690490(setd7)
OLA: 101168630(setd7)
PRET: 103470998(setd7)
CVG: 107098607(setd7)
NFU: 107387053(setd7)
KMR: 108240006(setd7)
ALIM: 106533608(setd7)
AOCE: 111573617(setd7)
CSEM: 103391447(setd7)
POV: 109627395(setd7)
LCF: 108875518(setd7)
SDU: 111230382(setd7)
SLAL: 111663588(setd7)
HCQ: 109529075(setd7)
BPEC: 110173499(setd7)
MALB: 109966416(setd7)
SASA: 106604693(setd7)
OTW: 112220930(setd7)
SALP: 111965713(setd7)
ELS: 105029145(setd7)
SFM: 108930830(setd7)
PKI: 111847325(setd7)
LCM: 102350182(SETD7)
CMK: 103181297(setd7)
RTP: 109919566(setd7)
BFO: 118404594
HMG: 101238060
AQU: 105311972
DFA: DFA_11520
SMIN: v1.2.013565.t1(symbB.v1.2.013565.t1)
 » show all
Reference
1  [PMID:11779497]
  Authors
Wang H, Cao R, Xia L, Erdjument-Bromage H, Borchers C, Tempst P, Zhang Y
  Title
Purification and functional characterization of a histone H3-lysine 4-specific methyltransferase.
  Journal
Mol Cell 8:1207-17 (2001)
  Sequence
[hsa:80854] [mmu:73251]
Reference
2  [PMID:11850410]
  Authors
Nishioka K, Chuikov S, Sarma K, Erdjument-Bromage H, Allis CD, Tempst P, Reinberg D
  Title
Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation.
  Journal
Genes Dev 16:479-89 (2002)
  Sequence
[hsa:80854]
Reference
3  [PMID:12372304]
  Authors
Wilson JR, Jing C, Walker PA, Martin SR, Howell SA, Blackburn GM, Gamblin SJ, Xiao B
  Title
Crystal structure and functional analysis of the histone methyltransferase SET7/9.
  Journal
Cell 111:105-15 (2002)
  Sequence
[hsa:80854]
Reference
4  [PMID:12540855]
  Authors
Xiao B, Jing C, Wilson JR, Walker PA, Vasisht N, Kelly G, Howell S, Taylor IA, Blackburn GM, Gamblin SJ
  Title
Structure and catalytic mechanism of the human histone methyltransferase SET7/9.
  Journal
Nature 421:652-6 (2003)
DOI:10.1038/nature01378
  Sequence
[hsa:80854]
Reference
5  [PMID:16433545]
  Authors
Hu P, Zhang Y
  Title
Catalytic mechanism and product specificity of the histone lysine methyltransferase SET7/9: an ab initio QM/MM-FE study with multiple initial structures.
  Journal
J Am Chem Soc 128:1272-8 (2006)
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.364
IUBMB Enzyme Nomenclature: 2.1.1.364
ExPASy - ENZYME nomenclature database: 2.1.1.364
BRENDA, the Enzyme Database: 2.1.1.364
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