KEGG   ENZYME: 2.1.1.366
Entry
EC 2.1.1.366                Enzyme                                 

Name
[histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase;
KMT1E (gene name);
SETDB1 (gene name);
KIAA0067 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:[histone H3]-N6,N6-dimethyl-L-lysine9 N6-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
Reaction(KEGG)
(other) R04867
Substrate
S-adenosyl-L-methionine [CPD:C00019];
[histone H3]-N6,N6-dimethyl-L-lysine9
Product
S-adenosyl-L-homocysteine [CPD:C00021];
[histone H3]-N6,N6,N6-trimethyl-L-lysine9
Comment
The enzyme methylates only dimethylated lysine9 of histone H3 (H3K9), forming the trimethylated form. This modification influences the binding of chromatin-associated proteins. In general, the methylation of H3K9 leads to transcriptional repression of the affected target genes. The enzyme is highly upregulated in Huntington disease patients. cf. EC 2.1.1.367, [histone H3]-lysine9 N-methyltransferase, and EC 2.1.1.368, [histone H3]-lysine9 N-dimethyltransferase, and EC 2.1.1.355, [histone H3]-lysine9 N-trimethyltransferase.
History
EC 2.1.1.366 created 2020
Pathway
ec00310  Lysine degradation
ec01100  Metabolic pathways
Orthology
K11421  [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase
Genes
HSA: 9869(SETDB1)
PTR: 469481(SETDB1)
PPS: 100972839(SETDB1)
GGO: 101146215(SETDB1)
PON: 100431310(SETDB1)
NLE: 100581330(SETDB1)
MCC: 716141(SETDB1)
MCF: 102117410(SETDB1)
CSAB: 103247223(SETDB1)
RRO: 104681064(SETDB1)
RBB: 108533259(SETDB1)
CJC: 100411734(SETDB1)
SBQ: 101042658(SETDB1)
MMU: 84505(Setdb1)
MCAL: 110291522(Setdb1)
MPAH: 110320737(Setdb1)
RNO: 689883(Setdb1)
MUN: 110560774(Setdb1)
CGE: 100765697(Setdb1)
NGI: 103730089(Setdb1)
HGL: 101715248(Setdb1)
CCAN: 109681205(Setdb1)
OCU: 100355877(SETDB1)
TUP: 102502264(SETDB1)
CFA: 483186(SETDB1)
VVP: 112907769(SETDB1)
AML: 100482250(SETDB1)
UMR: 103667532(SETDB1)
UAH: 113246155(SETDB1)
ORO: 101372094(SETDB1)
ELK: 111162065
FCA: 101094118(SETDB1)
PTG: 102970727(SETDB1)
PPAD: 109257028(SETDB1)
AJU: 106979835(SETDB1)
BTA: 100138100(SETDB1)
BOM: 102288279(SETDB1)
BIU: 109555305(SETDB1)
BBUB: 102408652(SETDB1)
CHX: 102180982(SETDB1)
OAS: 101109230(SETDB1)
SSC: 100157920(SETDB1)
CFR: 102512057(SETDB1)
CDK: 105103196(SETDB1)
BACU: 103009894(SETDB1)
LVE: 103076461(SETDB1)
OOR: 101270688(SETDB1)
DLE: 111169744(SETDB1)
ECB: 100059254(SETDB1)
EPZ: 103547642(SETDB1)
EAI: 106846522(SETDB1)
MYB: 102257713(SETDB1)
MYD: 102773684(SETDB1)
MNA: 107539129(SETDB1)
HAI: 109372277(SETDB1)
DRO: 112313537(SETDB1)
RAY: 107499036(SETDB1)
MJV: 108409453(SETDB1)
LAV: 100673374(SETDB1)
TMU: 101349341
MDO: 100618580(SETDB1)
SHR: 100928904(SETDB1)
PCW: 110220597(SETDB1)
OAA: 100091318(SETDB1)
GGA: 100859816(SETDB1)
MGP: 100542346(SETDB1)
CJO: 107324577(SETDB1)
NMEL: 110387900(SETDB1)
APLA: 101794756(SETDB1)
ACYG: 106049268(SETDB1)
TGU: 100231651(SETDB1)
LSR: 110476821(SETDB1)
SCAN: 103824025
GFR: 102034546(SETDB1)
PHI: 102101563(SETDB1)
PMAJ: 107214655(SETDB1)
CCAE: 111939473(SETDB1)
ETL: 114071955(SETDB1)
FPG: 101912073(SETDB1)
FCH: 102055212(SETDB1)
CLV: 102094505(SETDB1)
EGZ: 104129700(SETDB1)
NNI: 104014430(SETDB1)
ACUN: 113488725(SETDB1)
PADL: 103919479(SETDB1)
AAM: 106495416(SETDB1)
ASN: 102382539(SETDB1)
AMJ: 102575637(SETDB1)
CMY: 102937828(SETDB1)
CPIC: 101931963(SETDB1)
ACS: 100565799(setdb1)
PVT: 110081479(SETDB1)
PBI: 103053131(SETDB1)
PMUR: 107292899(SETDB1)
TSR: 106546292(SETDB1)
PMUA: 114586177(SETDB1)
GJA: 107121584(SETDB1)
XLA: 108700333(setdb1.S) 432147(setdb1.L)
XTR: 100490309(setdb1)
NPR: 108789810(SETDB1)
DRE: 553292(setdb1a) 768131(setdb1b)
IPU: 108266106(setdb1) 108272679
PHYP: 113535137 113542451(setdb1)
AMEX: 103027968(setdb1) 103028156
EEE: 113570608(setdb1) 113572599
TRU: 101075200(setdb1)
LCO: 104920543(setdb1)
NCC: 104944919(setdb1)
MZE: 101465322(setdb1)
ONL: 100710331(setdb1)
OLA: 101158302(setdb1)
XMA: 102235762(setdb1)
XCO: 114141956(setdb1)
PRET: 103478723(setdb1)
CVG: 107088829(setdb1)
NFU: 107379696(setdb1)
KMR: 108241152(setdb1)
ALIM: 106515090
AOCE: 111586482(setdb1)
CSEM: 103388279(setdb1)
POV: 109633224
LCF: 108885905(setdb1)
SDU: 111230127(setdb1)
SLAL: 111652197(setdb1)
HCQ: 109522778(setdb1)
BPEC: 110163046(setdb1)
MALB: 109970226
SALP: 111955709 111964582(setdb1)
ELS: 105018987(setdb1) 105030119
SFM: 108923796(setdb1)
PKI: 111853328(setdb1)
LCM: 102356699(SETDB1)
BFO: 118414026
CIN: 101242243
SPU: 764341
APLC: 110986848
SKO: 100372058
DME: Dmel_CG12196(egg)
DER: 6548401
DSE: 6618876
DSI: Dsimw501_GD24920(Dsim_GD24920)
DAN: 6494410
DSR: 110189614
DPE: 6592281
DWI: 6640308
DAZ: 108615991
DNV: 108654234
DHE: 111593833
DVI: 6626333
MDE: 101893339
LCQ: 111689074
AALB: 109429413
AME: 409098
BIM: 100745488
BTER: 100647514
CCAL: 108631329
OBB: 114874120
SOC: 105201335
MPHA: 105833491
AEC: 105144993
ACEP: 105620791
PBAR: 105429250
VEM: 105561499
HST: 105186113
DQU: 106745347
CFO: 105256000
LHU: 105670399
PGC: 109857860
OBO: 105284457
PCF: 106790393
NVI: 100120014
CSOL: 105360527
MDL: 103577834
TCA: 658295
DPA: 109543261
NVL: 108566549
BMOR: 101742950
BMAN: 114244119
PMAC: 106721248
PRAP: 110997400
TNL: 113502290
BTAB: 109030364
ZNE: 110837361
TUT: 107372205
PTEP: 107451716
CEL: CELE_R05D3.11(met-2)
CBR: CBG18157(Cbr-met-2)
BMY: Bm1_19995
PCAN: 112559730
CRG: 105332598
MYI: 110459908
OBI: 106873585
LAK: 106167373
SHX: MS3_06263
EGL: EGR_06122
NVE: 5506681
EPA: 110238173
AMIL: 114974694
PDAM: 113666302
DGT: 114527359
HMG: 100203637
 » show all
Reference
1  [PMID:11791185]
  Authors
Yang L, Xia L, Wu DY, Wang H, Chansky HA, Schubach WH, Hickstein DD, Zhang Y
  Title
Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor.
  Journal
Oncogene 21:148-52 (2002)
DOI:10.1038/sj.onc.1204998
  Sequence
[mmu:84505]
Reference
2  [PMID:14536086]
  Authors
Wang H, An W, Cao R, Xia L, Erdjument-Bromage H, Chatton B, Tempst P, Roeder RG, Zhang Y
  Title
mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression.
  Journal
Mol Cell 12:475-87 (2003)
Reference
3  [PMID:22939622]
  Authors
Pinheiro I, Margueron R, Shukeir N, Eisold M, Fritzsch C, Richter FM, Mittler G, Genoud C, Goyama S, Kurokawa M, Son J, Reinberg D, Lachner M, Jenuwein T
  Title
Prdm3 and Prdm16 are H3K9me1 methyltransferases required for mammalian heterochromatin integrity.
  Journal
Cell 150:948-60 (2012)
DOI:10.1016/j.cell.2012.06.048
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.366
IUBMB Enzyme Nomenclature: 2.1.1.366
ExPASy - ENZYME nomenclature database: 2.1.1.366
BRENDA, the Enzyme Database: 2.1.1.366
LinkDB

DBGET integrated database retrieval system