| Entry |
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| Name |
DNA (cytosine-5-)-methyltransferase;
EcoRI methylase;
DNA 5-cytosine methylase;
DNA cytosine C5 methylase;
DNA cytosine methylase;
DNA methylase (ambiguous);
DNA methyltransferase (ambiguous);
DNA transmethylase (ambiguous);
DNA-cytosine 5-methylase;
DNA-cytosine methyltransferase;
HpaII methylase;
HpaII' methylase;
M.BsuRIa;
M.BsuRIb;
Type II DNA methylase;
cytosine 5-methyltransferase;
cytosine DNA methylase;
cytosine DNA methyltransferase;
cytosine-specific DNA methyltransferase;
deoxyribonucleate methylase (ambiguous);
deoxyribonucleate methyltransferase (ambiguous);
deoxyribonucleic (cytosine-5-)-methyltransferase;
deoxyribonucleic acid (cytosine-5-)-methyltransferase;
deoxyribonucleic acid methylase (ambiguous);
deoxyribonucleic acid methyltransferase (ambiguous);
deoxyribonucleic acid modification methylase (ambiguous);
deoxyribonucleic methylase (ambiguous);
methylphosphotriester-DNA methyltransferase (ambiguous);
modification methylase (ambiguous);
restriction-modification system (ambiguous);
site-specific DNA-methyltransferase (cytosine-specific);
DNA-(cytosine C5)-methylase
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| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
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| Sysname |
S-adenosyl-L-methionine:DNA (cytosine-5-)-methyltransferase
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| Reaction(IUBMB) |
S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine [RN: R00380]
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| Reaction(KEGG) |
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| Substrate |
S-adenosyl-L-methionine [CPD: C00019];
DNA containing cytosine
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| Product |
S-adenosyl-L-homocysteine [CPD: C00021];
DNA containing 5-methylcytosine [CPD: C02967]
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| History |
EC 2.1.1.37 created 1972, (EC 2.1.1.73 incorporated 2003), modified 2003
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| Pathway |
| ec00270 | Cysteine and methionine metabolism |
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| Orthology |
| K00558 | DNA (cytosine-5)-methyltransferase 1 |
| K17398 | DNA (cytosine-5)-methyltransferase 3A |
| K17399 | DNA (cytosine-5)-methyltransferase 3B |
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| Genes |
» show all
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| Reference |
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| Authors |
GOLD M, HURWITZ J. |
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| Title |
THE ENZYMATIC METHYLATION OF RIBONUCLEIC ACID AND DEOXYRIBONUCLEIC ACID. V. PURIFICATION AND PROPERTIES OF THE DEOXYRIBONUCLEIC ACID-METHYLATING ACTIVITY OF ESCHERICHIA COLI. |
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| Journal |
J Biol Chem 239:3858-65 (1964) |
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| Reference |
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| Authors |
Kalousek F, Morris NR. |
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| Title |
The purification and properties of deoxyribonucleic acid methylase from rat spleen. |
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| Journal |
J Biol Chem 244:1157-63 (1969) |
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| Reference |
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| Authors |
Roy PH, Weissbach A. |
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| Title |
DNA methylase from HeLa cell nuclei. |
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| Journal |
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| Reference |
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| Authors |
Simon D, Grunert F, von Acken U, Doring HP, Kroger H. |
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| Title |
DNA-methylase from regenerating rat liver: purification and characterisation. |
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| Journal |
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| Reference |
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| Authors |
Sneider TW, Teague WM, Rogachevsky LM. |
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| Title |
S-adenosylmethionine: DNA-cytosine 5-methyltransferase from a Novikoff rat hepatoma cell line. |
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| Journal |
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| Reference |
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| Authors |
Turnbull JF, Adams RL. |
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| Title |
DNA methylase: purification from ascites cells and the effect of various DNA substrates on its activity. |
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| Journal |
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| Reference |
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| Authors |
Kessler C, Manta V. |
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| Title |
Specificity of restriction endonucleases and DNA modification methyltransferases a review (Edition 3). |
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| Journal |
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| Reference |
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| Authors |
Roberts RJ. |
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| Title |
Restriction enzymes and their isoschizomers. |
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| Journal |
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| Reference |
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| Authors |
Yuan R. |
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| Title |
Structure and mechanism of multifunctional restriction endonucleases. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.1.1.37 |
| ExPASy - ENZYME nomenclature database: | 2.1.1.37 |
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| LinkDB |
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