KEGG   ENZYME: 2.1.1.371
Entry
EC 2.1.1.371                Enzyme                                 

Name
[histone H3]-lysine27 N-dimethyltransferase;
NSD3 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:[histone H3]-L-lysine27 N6-dimethyltransferase
Reaction(IUBMB)
2 S-adenosyl-L-methionine + a [histone H3]-L-lysine27 = 2 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine27 (overall reaction);
(1a) S-adenosyl-L-methionine + a [histone H3]-L-lysine27 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine27;
(1b) S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine27 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine27
Reaction(KEGG)
(other) R03875 R04866
Substrate
S-adenosyl-L-methionine [CPD:C00019];
[histone H3]-L-lysine27;
[histone H3]-N6-methyl-L-lysine27
Product
S-adenosyl-L-homocysteine [CPD:C00021];
[histone H3]-N6,N6-dimethyl-L-lysine27;
[histone H3]-N6-methyl-L-lysine27
Comment
This entry describes enzymes that successively methylate the L-lysine27 residue of histone H3 (H3K27) twice, ultimately generating a dimethylated form. These modifications influence the binding of chromatin-associated proteins. The human NSD3 protein also catalyses the activity of EC 2.1.1.370, [histone H3]-lysine4 N-dimethyltransferase. cf. EC 2.1.1.369, [histone H3]-lysine27 N-methyltransferase, and EC 2.1.1.356, [histone H3]-lysine27 N-trimethyltransferase.
History
EC 2.1.1.371 created 2020
Pathway
ec00310  Lysine degradation
ec01100  Metabolic pathways
Orthology
K11425  [histone H3]-lysine4 N-dimethyltransferase / [histone H3]-lysine27 N-dimethyltransferase
Genes
HSA: 54904(NSD3)
PTR: 464119(NSD3)
PPS: 100989573(NSD3)
GGO: 101127408(NSD3)
PON: 100459660(NSD3)
NLE: 100599595(NSD3)
MCC: 700254(NSD3)
MCF: 102138188(NSD3)
CSAB: 103215646(NSD3)
RRO: 104679642(NSD3)
RBB: 108512402(NSD3)
CJC: 100389349(NSD3)
SBQ: 101031525(WHSC1L1)
MMU: 234135(Nsd3)
MCAL: 110299577(Nsd3)
MPAH: 110337154(Nsd3)
RNO: 290831(Nsd3)
MUN: 110563304(Nsd3)
CGE: 100773097(Nsd3)
NGI: 103745768(Nsd3)
HGL: 101703406(Nsd3)
CCAN: 109688938(Nsd3)
OCU: 100352710(NSD3)
TUP: 102487161(NSD3)
CFA: 475584(NSD3)
VVP: 112916135(NSD3)
AML: 100473259(NSD3)
UMR: 103659130(NSD3)
UAH: 113262089(NSD3)
ORO: 101364354(WHSC1L1)
ELK: 111144613
FCA: 101086901(NSD3)
PTG: 102949086(NSD3)
PPAD: 109262146(NSD3)
AJU: 106978378(NSD3)
BTA: 513054(NSD3)
BOM: 102268973(NSD3)
BIU: 109553299(NSD3)
BBUB: 102408813(NSD3)
CHX: 102188284(NSD3)
OAS: 101112880(NSD3)
SSC: 100520868(NSD3)
CFR: 102515779(NSD3)
CDK: 105089934(NSD3)
BACU: 103016894(NSD3)
LVE: 103072101(NSD3)
OOR: 101278951(WHSC1L1)
DLE: 111173519
PCAD: 102990993(NSD3)
ECB: 100057692(NSD3)
EPZ: 103560265(NSD3)
EAI: 106824653(NSD3)
MYB: 102252817(NSD3)
MYD: 102759770(NSD3)
MNA: 107535114(WHSC1L1)
HAI: 109373158(NSD3)
DRO: 112306746(NSD3)
PALE: 102879344(NSD3)
RAY: 107515960(WHSC1L1)
MJV: 108396577(WHSC1L1)
LAV: 100663420(NSD3)
TMU: 101341096
MDO: 100029834(NSD3)
SHR: 100913907(NSD3)
PCW: 110207576(NSD3)
OAA: 100074284(NSD3)
GGA: 426778(WHSC1L1)
MGP: 100550821(NSD3)
CJO: 107323733(NSD3)
NMEL: 110387045(NSD3)
APLA: 101796335(NSD3)
ACYG: 106044410(WHSC1L1)
TGU: 100224170(NSD3)
LSR: 110473395(NSD3)
SCAN: 103822694(NSD3)
GFR: 102033572(NSD3)
FAB: 101807043(NSD3)
PHI: 102104727(NSD3)
PMAJ: 107213840(WHSC1L1)
CCAE: 111938845(NSD3)
CCW: 104694849(NSD3)
ETL: 114066496(NSD3)
FPG: 101913589(NSD3)
FCH: 102055544(NSD3)
CLV: 102090497(NSD3)
EGZ: 104125799(WHSC1L1)
NNI: 104016016(WHSC1L1)
ACUN: 113488073(NSD3)
PADL: 103912352(WHSC1L1)
AAM: 106493055(NSD3)
ASN: 102385195(NSD3)
AMJ: 106736778(NSD3)
PSS: 102457400(NSD3)
CMY: 102943320(NSD3)
CPIC: 101938886(NSD3)
ACS: 100558428(nsd3)
PVT: 110072168(NSD3)
PBI: 103067854(NSD3)
PMUR: 107289990(NSD3)
TSR: 106550392(WHSC1L1)
PMUA: 114585486(NSD3)
GJA: 107112988(NSD3)
XLA: 108711640(nsd3.L)
XTR: 100216035(nsd3)
NPR: 108800629(WHSC1L1)
DRE: 100006350(whsc1l1)
SGH: 107553696(whsc1l1)
IPU: 108277349(nsd3)
PHYP: 113544017(nsd3)
AMEX: 103025001(nsd3)
EEE: 113582471(nsd3)
TRU: 101063468(nsd3)
LCO: 109137146(nsd3)
NCC: 104951617(whsc1l1)
MZE: 101481339(nsd3)
ONL: 100692732(nsd3)
OLA: 101156018(nsd3)
XMA: 102222057(nsd3)
XCO: 114154602(nsd3)
PRET: 103470645(whsc1l1)
CVG: 107089672(whsc1l1)
NFU: 107394238(whsc1l1)
KMR: 108233751(nsd3)
ALIM: 106513637(whsc1l1)
AOCE: 111573350(nsd3)
POV: 109637173(nsd3)
LCF: 108881778(whsc1l1)
SDU: 111237743(nsd3)
SLAL: 111661024(nsd3)
HCQ: 109525952(nsd3)
BPEC: 110156434(nsd3)
MALB: 109956650(nsd3)
ELS: 105014331(nsd3)
SFM: 108934463 108940378(nsd3)
PKI: 111851463 111857590(nsd3)
LCM: 102359965(NSD3)
CMK: 103190419(nsd3)
RTP: 109912039
 » show all
Reference
1  [PMID:16682010]
  Authors
Kim SM, Kee HJ, Eom GH, Choe NW, Kim JY, Kim YS, Kim SK, Kook H, Kook H, Seo SB
  Title
Characterization of a novel WHSC1-associated SET domain protein with H3K4 and H3K27 methyltransferase activity.
  Journal
Biochem Biophys Res Commun 345:318-23 (2006)
DOI:10.1016/j.bbrc.2006.04.095
  Sequence
[hsa:54904] [mmu:234135]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.371
IUBMB Enzyme Nomenclature: 2.1.1.371
ExPASy - ENZYME nomenclature database: 2.1.1.371
BRENDA, the Enzyme Database: 2.1.1.371
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