| Entry |
|
| Name |
betaine---homocysteine S-methyltransferase;
betaine-homocysteine methyltransferase;
betaine-homocysteine transmethylase
|
| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
|
| Sysname |
trimethylammonioacetate:L-homocysteine S-methyltransferase
|
| Reaction(IUBMB) |
betaine + L-homocysteine = dimethylglycine + L-methionine [RN: R02821]
|
| Reaction(KEGG) |
|
| Substrate |
|
| Product |
|
| History |
EC 2.1.1.5 created 1961
|
| Pathway |
| ec00260 | Glycine, serine and threonine metabolism |
| ec00270 | Cysteine and methionine metabolism |
| ec01110 | Biosynthesis of secondary metabolites |
|
| Orthology |
| K00544 | betaine-homocysteine S-methyltransferase |
|
| Genes |
| MMIU: | 308427343(LOC308427343) |
| DMER: | 138832935 138837136 |
| MAVE: | 308276202(LOC308276202) |
| MMAQ: | 308343700(LOC308343700) |
| SCOO: | 307184595(ACYUVP_009868) |
| HAMP: | 307052581(LOC307052581) |
| POTS: | 308254926(AC0HY7_021759) |
| OAA: | 100088080 100088098(BHMT2) |
| TACU: | 119944560 119944759 |
| MGP: | 100541641(LOC100541641) |
| BCLA: | 308455295(LOC308455295) |
| ABRC: | 308185247(LOC308185247) |
| LCAI: | 146424912(LOC146424912) |
| PECH: | 308232363(LOC308232363) |
| PLEC: | 309602433(LOC309602433) |
| CBOR: | 142075069 142076083 |
| NMAY: | 308052198(LOC308052198) |
| CEUR: | 306731163(LOC306731163) |
| HEK: | 139789603(LOC139789603) |
| MRV: | 120408209(LOC120408209) |
| SRX: | 107717756 107724714(bhmt) |
| CCAR: | 109046108(bhmt) 122141253 |
| CAUA: | 113080755 113097702 |
| CGIB: | 127942096 127986306 |
| CHAR: | 105901160 105901214 105902436(bhmt) 105910603 |
| SPIL: | 134088344 134088775 134088777 134101044(bhmt) |
| ASAD: | 121679640(bhmt) 121715062 121715066 121716102 |
| TRU: | 101061373 101062063(bhmt) |
| TFS: | 130517451(bhmt) 130526444 |
| NCC: | 104943386 104943387 104948669 104948670 104966862 |
| TBEN: | 117472348 117475958 117476489(bhmt) |
| CGOB: | 115013331 115013368 115013615 115016357 |
| PGEO: | 117452088 117455756(bhmt) |
| GACU: | 117536708 117560599 117560604 117561495 |
| EMAC: | 134868888(bhmt) 134873351 134873820 134874286 |
| ELY: | 117251874 117252237 117252925 117252926 117269200 117269931 |
| EFO: | 125890425 125890426 125890449 125890450 125906136 |
| PLEP: | 121944080 121944246 121944247 121944389 |
| SLUC: | 116054167 116054168 116056791 116062994(bhmt) |
| SVIT: | 144517651 144517652 144518133 144531793(bhmt) |
| ECRA: | 117945057 117945058 117945219 117959558(bhmt) |
| PFLV: | 114555694 114555876 114555939 114570759 |
| PFLT: | 120545378(bhmt) 120560760 120561270 120561271 |
| GAT: | 120830956 120830957 120831287 120832005(bhmt) |
| PPUG: | 119224706 119224707 119225361 119225362 119226903(bhmt) |
| AFB: | 129100666 129100667 129100923 129100924 129102188 |
| CLUM: | 117735983 117736261 117736815 117736816 117740696 117740910(bhmt) |
| PSWI: | 130196706 130197168 130197169 130205406(bhmt) |
| CANA: | 137784199(bhmt) 137805078 137805080 137805226 137805389 |
| TBU: | 306739712(LOC306739712) 306740046(LOC306740046) 306740181(LOC306740181) 306740322(LOC306740322) 306740641(LOC306740641) 306751197(bhmt) |
| CVE: | 137866901 137866902 137866973 137867003 137868758 137869252 |
| AMIR: | 142955036(bhmt) 142957529 142957531 142957700 142957701 |
| MSAM: | 119891844 119914971(bhmt) |
| SCHU: | 122865754 122876422 122876937 122876938 |
| EARM: | 139284081 139284166 139284193 139284204 139301060(bhmt) |
| CUD: | 121509995 121510073 121510074 121510092 121525687(bhmt) |
| SPUL: | 138601888 138610185 138610304 138610395 138610588 |
| LMIX: | 132974167 132974168 132974539 132974540 132992692(bhmt) |
| HTC: | 141790579 141790648 141790659 141790741 141790747 141805302(bhmt) |
| ALAT: | 119018856 119018903 119018904 119019260 119019508 119030143 |
| ASTR: | 137592480 137592725 137592798 137608241 |
| PKLU: | 139203373 139204087 139204183 139218899(bhmt) |
| LCO: | 104921205 104921289 104930138 104930139 104936284 |
| AMMM: | 307257480(LOC307257480) 307259569(LOC307259569) 307265130(LOC307265130) 307267748(LOC307267748) |
| MZE: | 101464577 101482601(bhmt) 112435685 |
| ONL: | 100704302 100705166 100705436 |
| OAU: | 116315584 116328388 116328389 |
| OML: | 112148056 112162826(bhmt) |
| CSAI: | 133450647 133450648 133454611(bhmt) |
| XMA: | 102218191 102225771 102226035 |
| XCO: | 114149906 114154707 114154708 |
| XHE: | 116724267 116730429 116730431 |
| PRET: | 103470080 103470081 103473309(bhmt) |
| PFOR: | 103135835 103141748 |
| PLAI: | 106937104 106956825 |
| PMEI: | 106916212 106923054 |
| GAF: | 122819377(bhmt) 122827328 122827332 |
| PPRL: | 129365809 129374187(bhmt) |
| CVG: | 107092421 107092484 107093785 |
| CTUL: | 119788268(bhmt) 119798561 119798562 |
| GMU: | 124873094(bhmt) 124877131 |
| KMR: | 108233717 108233718 108251296(bhmt) |
| ALIM: | 106513660 106532974 |
| LTU: | 140277454(bhmt) 140309684 140309685 |
| TBT: | 306764276(LOC306764276) 306764449(LOC306764449) 306768216(bhmt) |
| MCEP: | 124996948(bhmT) 125012487 125012488 125012755 125012756 |
| AOCE: | 111564721 111564722 111570352 111581621 |
| EJA: | 138191795 138191980 138207512(bhmt) 138215909 |
| BFRE: | 138622957(bhmt) 138626245 138626246 138627213 |
| LCF: | 108878770 108882050 108882056 108895445(bhmt) |
| CSEM: | 103390007 103397629 |
| POV: | 109625962 109637078 109637079 109638087 |
| SSEN: | 122758689(bhmt) 122769031 122769454 |
| SSOE: | 131446761(bhmt) 131463421 131463502 |
| HHIP: | 117767260 117768517 117768519 117771585(bhmt) |
| HSP: | 118098097 118114836 118114895 118114896 |
| PPLT: | 128424855 128437929 128438014 128438016 |
| SMAU: | 118301462(bhmt) 118313322 118314207 118314208 |
| SDU: | 111229230 111237735 111237759 111239026 |
| SLAL: | 111651687 111651689 111660294 111666825 |
| SSCV: | 125979297(bhmt) 125994694 |
| SBIA: | 133499786 133515234 |
| PEE: | 133399939 133413362(bhmt) |
| PTAO: | 133475179 133489844(bhmt) |
| BPEC: | 110156680 110156723 110157444 110172084 110172085 |
| ENY: | 140346518 140346520 140347164 140347221 140367764(bhmt) |
| MALB: | 109953000 109956508 |
| BSPL: | 114862603 114867454(bhmt) |
| SJO: | 128364714 128364715 128364815 128365203 128380740 |
| SSCO: | 133978839 133978840 133979669 133979671 133995006(bhmt) |
| TTY: | 137170722 137195877 137199400 137199405 |
| GMH: | 115541269 115545184 115545185 115546034 |
| ZFA: | 307232231(LOC307232231) 307232418(LOC307232418) 307233028(LOC307233028) 307242893(LOC307242893) |
| SASA: | 100194600(bhmt) 106568115 |
| STRU: | 115159735(bhmt) 115203928 |
| OTW: | 112220278(bhmt) 112230819 |
| OMY: | 110509664 110523446(bhmt) |
| OCLA: | 139387782 139408525 |
| SALP: | 111961763 111963903 |
| SFON: | 129818244 129863801 |
| CCLU: | 121541555 121582649 |
| OEP: | 134011943 134038755(bhmt) |
| SFM: | 108925116 108925117(bhmt) |
| PKI: | 111849814(bhmt) 111849880 |
| AANG: | 118213304 118213305(bhmt) 118237452 |
| AROT: | 135233340 135239250 135239251(bhmt) |
| CCOG: | 133140891 133141899 133141995 |
| PSPA: | 121305143 121313674 |
| ARUT: | 117403613 117974146 |
| LERI: | 129694867 129714267 |
| MGLT: | 137418280(LOC137418280) |
| BFO: | 118403599 118403625 118403740 118403835 118408941 118409375 118412861 118419165 118419166 118420119 118422786 118423158 118423159 |
| BBEL: | 109462372 109463244 109464847 109467561 109472834 109474178 109474209 109474210 109476287 109481064 |
| CIN: | 100180493 100181849 100182838 113474336 |
| SCLV: | 120326246 120327870 120328505 120328506 120328890 |
| CLEP: | 143449109 143450334 143451994 143470931 |
| SPU: | 100891161 105438577 105447246 115918144 115918913 115928328 115929946 575553 579857 580174 582813 588895 589758 752628 |
| LPIC: | 129258483 129258484 129258534 129259077 129259157 129259605 129262595 129264145 129265678 |
| LVG: | 121412565 121412567 121412605 121412606 121412617 121412893 121412894 121412895 121412908 121412910 121413428 121413459 121413680 121416265 121416295 121418373 121418374 121426596 |
| AJJ: | 139958528 139962507 139962965 139971535 139971536 139971538 139971539 139971607 139971611 139979195 |
| APLC: | 110974267 110984631 110984637 110984652 110984655 110984668 110984669 110984679 110986934 110987105 110988857 110990180 |
| PMIN: | 119730495 119730497 119730718 119730814 119730819 119730874 119736825 119738007 119740668 |
| ARUN: | 117291614 117291624 117295761 117296186 117296591 117296670 117297075 117300418 |
| AAMU: | 139941757 139942123 139943076 139943351 139943362 139946702 139946703 139946735 |
| AFIL: | 140152622 140156315 140156934 140159233 140160598 140163633 140166003 140166390 |
| AJC: | 117103427 117116060 117122225 |
| SKO: | 100371248 100372758 100372908 100374951 100376137 100376292 100376597 100378429 100378580 100378727 102807376 |
| PFLL: | 139121850 139133372 139133941 139133968 139133978 139133986 139134005 139140876 139140901 139141733 139142385 139142397 139142398 139142400 139142401 139142402 139142403 139142412 139142414 139142415 139142417 139142418 |
| IEL: | 124154290(LOC124154290) |
| EAF: | 111700817 111700974 111708867 |
| PVM: | 113808272 113817434 113819630 |
| PJA: | 122245301 122247003 122258389 122266441 |
| PCHN: | 125033259 125033278 125035210 125035256 |
| PMOO: | 119577942 119583518 119583532 |
| HAME: | 121878891 121878895 |
| PTRU: | 123504391 123504392 123504421 123512443 |
| SPRM: | 135107446 135107447 135107448 135116353 |
| ESN: | 126997661 126997662 127008696 |
| MNZ: | 135208776 135208777 135213177 |
| MRJ: | 136826229 136846065 136846068 |
| PORN: | 139749753 139760460 |
| PPOI: | 119090929 119094136 119096867 |
| RSAN: | 119387357 119387358 |
| SDM: | 118188532(LOC118188532) 118195838(LOC118195838) |
| LPOL: | 106462891 106462894 106462895 |
| LGI: | LOTGIDRAFT_183387 LOTGIDRAFT_217867 LOTGIDRAFT_230320 LOTGIDRAFT_233748 |
| PVUL: | 126809610 126811534 126812388 126812389 126812390 126827744 130010354 130010432 130013622 |
| LSAX: | 138960908 138965360 |
| BARL: | 143282965 143284718 143297917 143298044 143298152 |
| HRF: | 124129484 124137148 124138282 124138283 124138284 124140307 124140311 124140312 124146516 124146517 124146524 |
| HRJ: | 124262605 124262606 124262607 124262608 124262609 124269213 124269214 124280593 124289090 124291430 124291446 |
| HASI: | 137286727 137286733 137286921 137287159 137287244 137287245 137287376 137287378 137287762 137296959 137296960 137296962 137296963 137296965 137296966 |
| HCRA: | 139444851 139445633 139474066 139474383 139474414 139474940 139474942 139475024 139475252 139475572 |
| CANU: | 128159878 128161362 128184450 128185728 |
| CVN: | 111102594 111108276 111109969 |
| OED: | 125674091 125674093 125676132 125676585 125677062 130048310 130048311 |
| MYI: | 110455538 110456381 110456382 110456384 110456469 110458153 110464929 110464943 110467328 |
| PMAX: | 117326857 117326858 117326859 117327192 117327193 117327194 117327227 117328542 117330294 117331264 117331595 |
| AIRR: | 138305195 138335688 138335743 138336061 138336311 138336814 |
| YBA: | 132545004 132545991 132559060 132560696 132561311 132561326 132561327 132561333 132563424 |
| MMER: | 123527072 123528071 123536698 123546866 123546873 123548659 123548660 123550078 123551338 123551339 123551349 123552786 128556290 |
| RPHI: | 132734918 132738754 132738770 132746720 132747124 132747125 132749131 132749132 |
| DPOL: | 127841289 127850279 |
| MAEA: | 128216893 128218132 128218565 128236706 128237814 128238828 128239155 128239236 |
| OSN: | 115222737 115222981 115223003 |
| LJP: | 135468805 135472210 135479334 135481780 135481872 |
| LAK: | 106156503 106166038 106166449 106167822 106171079 106171080 106171100 106178981 106179201 |
| LLON: | 135482447 135484100 135484156 135485181 135497945 135498145 135498158 |
| EPA: | 110231416 110238130 110238131 110238132 110240957 110240959 110240960 110242935 110246242 |
| ATEN: | 116294619 116295943 116297504 116297506 116297515 116301137 |
| AMIL: | 114950037 114953867 114960594 114974172 |
| AMUA: | 136890792 136890815 136930387 136931135 |
| MCAZ: | 138038991 138049022 138049023 |
| MFOO: | 137984993 137985217 137992654 |
| PDAM: | 113672660 113673312 113674473 113682319 113686957 |
| SPIS: | 111324403 111336507 111338100 111344161 |
| OPG: | 144631113(LOC144631113) 144631117(LOC144631117) 144659404(LOC144659404) 144661642(LOC144661642) 144661803(LOC144661803) 144661994(LOC144661994) 144662244(LOC144662244) 144663851(LOC144663851) 144663881(LOC144663881) |
| DGT: | 114518175 114533873 114540583 |
| HMG: | 100206048(LOC100206048) |
| HSY: | 130640717 130640969 130641098 130645044 130649193 |
| RES: | 135687789 135688357 135688409 |
| TAD: | TRIADDRAFT_63716 TRIADDRAFT_63717 |
| AQU: | 100638323 100639967 100640174 100640299 105315720 |
| CCLM: | 134186429 134187277 134195303 |
| FMI: | F0R74_09025 F0R74_09035 |
| APC: | HIMB59_00001060 HIMB59_00005120 HIMB59_00005130 |
| DCO: | SAMEA4475696_1438(metH_1) |
» show all
|
| Reference |
|
| Authors |
KLEE WA, RICHARDS HH, CANTONI GL. |
| Title |
The synthesis of methionine by enzymic transmethylation. VII. Existence of two separate homocysteine methylpherases on mammalian liver. |
| Journal |
|
| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.1.1.5 |
| ExPASy - ENZYME nomenclature database: | 2.1.1.5 |
| BRENDA, the Enzyme Database: | 2.1.1.5 |
|
| LinkDB |
|