KEGG   ENZYME: 2.1.1.59
Entry
EC 2.1.1.59                 Enzyme                                 
Name
[cytochrome c]-lysine N-methyltransferase;
cytochrome c (lysine) methyltransferase;
cytochrome c methyltransferase;
cytochrome c-specific protein methylase III;
cytochrome c-specific protein-lysine methyltransferase;
S-adenosyl-L-methionine:[cytochrome c]-L-lysine 6-N-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:[cytochrome c]-L-lysine N6-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + [cytochrome c]-L-lysine = S-adenosyl-L-homocysteine + [cytochrome c]-N6-methyl-L-lysine [RN:R04145]
Reaction(KEGG)
R04145;
(other) R03875 R04866 R04867
Substrate
S-adenosyl-L-methionine [CPD:C00019];
[cytochrome c]-L-lysine
Product
S-adenosyl-L-homocysteine [CPD:C00021];
[cytochrome c]-N6-methyl-L-lysine
Comment
One of a group of enzymes methylating proteins; see also EC 2.1.1.43 histone-lysine N-methyltransferase and EC 2.1.1.60 calmodulin-lysine N-methyltransferase.
History
EC 2.1.1.59 created 1982, modified 1983
Pathway
ec00310  Lysine degradation
ec01100  Metabolic pathways
Orthology
K18804  [cytochrome c]-lysine N-methyltransferase
Genes
SCEYHR109W(CTM1)
AGOAGOS_AER246W
KLAKLLA0_E21407g
KMXKLMA_20447(CTM1)
LTHKLTH0F16390g
VPOKpol_530p1
ZROZYRO0F09680g
CGRCAGL0I01210g
NCSNCAS_0H02000(NCAS0H02000)
NDINDAI_0C01650(NDAI0C01650)
TPFTPHA_0E01820(TPHA0E01820)
TDLTDEL_0E02050(TDEL0E02050)
TGBHG536_0E00850
KAFKAFR_0D04990(KAFR0D04990)
ZMKHG535_0C04020
PPAPAS_chr1-1_0152
DHADEHA2G04466g
PICPICST_86656(CTM1)
PGUPGUG_02969
SPAASPAPADRAFT_147638
LELLELG_05244
CALCAALFM_CR10360CA(CTM1)
CTPCTRG_05818
COTCORT_0D00570
CDUCD36_35280
CTENCANTEDRAFT_132629
CLUCLUG_01538
CLUSA9F13_06g03619
CAURCJI97_000546
PKZC5L36_0A03800
BNNFOA43_001795
BBRXBRETT_004710
 » show all
Reference
1  [PMID:203592]
  Authors
Durban E, Nochumson S, Kim S, Paik WK, Chan SK.
  Title
Cytochrome c-specific protein-lysine methyltransferase from Neurospora crassa. Purification, characterization, and substrate requirements.
  Journal
J Biol Chem 253:1427-35 (1978)
Reference
2  [PMID:196592]
  Authors
Nochumson S, Durban E, Kim S, Paik WK.
  Title
Cytochrome c-specific protein methylase III from Neurospora crassa.
  Journal
Biochem J 165:11-8 (1977)
DOI:10.1042/bj1650011
Reference
3  [PMID:6282265]
  Authors
Valentine J, Pettigrew GW.
  Title
A cytochrome c methyltransferase from Crithidia oncopelti.
  Journal
Biochem J 201:329-38 (1982)
DOI:10.1042/bj2010329
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.59
IUBMB Enzyme Nomenclature: 2.1.1.59
ExPASy - ENZYME nomenclature database: 2.1.1.59
BRENDA, the Enzyme Database: 2.1.1.59
CAS: 82047-78-7
LinkDB

DBGET integrated database retrieval system