KEGG   ENZYME: 2.1.5.1
Entry
EC 2.1.5.1                  Enzyme                                 

Name
sesamin methylene transferase;
sesA (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methylenetransferases
Sysname
(+)-sesamin:tetrahydrofolate N-methylenetransferase
Reaction(IUBMB)
(1) (+)-sesamin + tetrahydrofolate = (+)-demethylpiperitol + 5,10-methylenetetrahydrofolate [RN:R11955];
(2) (+)-demethylpiperitol + tetrahydrofolate = (+)-didemethylpinoresinol + 5,10-methylenetetrahydrofolate [RN:R11956]
Reaction(KEGG)
R11955 R11956
Substrate
(+)-sesamin [CPD:C10882];
tetrahydrofolate [CPD:C00101];
(+)-demethylpiperitol [CPD:C21801]
Product
(+)-demethylpiperitol [CPD:C21801];
5,10-methylenetetrahydrofolate [CPD:C00143];
(+)-didemethylpinoresinol [CPD:C21802]
Comment
This enzyme was characterized from the bacterium Sinomonas sp. No.22. It catalyses a cleavage of a methylene bridge, followed by the transfer of the methylene group to tetrahydrofolate. The enzyme is also active with (+)-episesamin, (-)-asarinin, (+)-sesaminol, (+)-sesamolin, and piperine.
History
EC 2.1.5.1 created 2018
Orthology
K22578  sesamin methylene transferase
Reference
1  [PMID:27444012]
  Authors
Kumano T, Fujiki E, Hashimoto Y, Kobayashi M
  Title
Discovery of a sesamin-metabolizing microorganism and a new enzyme.
  Journal
Proc Natl Acad Sci U S A 113:9087-92 (2016)
DOI:10.1073/pnas.1605050113
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.5.1
IUBMB Enzyme Nomenclature: 2.1.5.1
ExPASy - ENZYME nomenclature database: 2.1.5.1
BRENDA, the Enzyme Database: 2.1.5.1
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