KEGG   ENZYME: 2.3.1.169
Entry
EC 2.3.1.169                Enzyme                                 

Name
CO-methylating acetyl-CoA synthase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
acetyl-CoA:corrinoid protein O-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + a [Co(I) corrinoid Fe-S protein] = CO + CoA + a [methyl-Co(III) corrinoid Fe-S protein] [RN:R08433]
Reaction(KEGG)
R08433;
(other) R09317 R10243
Substrate
acetyl-CoA [CPD:C00024];
[Co(I) corrinoid Fe-S protein]
Product
CO [CPD:C00237];
CoA [CPD:C00010];
[methyl-Co(III) corrinoid Fe-S protein]
Comment
Contains nickel, copper and iron-sulfur clusters. Involved, together with EC 1.2.7.4, carbon-monoxide dehydrogenase (ferredoxin), in the synthesis of acetyl-CoA from CO2 and H2.
History
EC 2.3.1.169 created 2003, modified 2015
Pathway
ec00720  Carbon fixation pathways in prokaryotes
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00193  acetyl-CoA decarbonylase/synthase, CODH/ACS complex subunit beta
K14138  acetyl-CoA synthase
Genes
BBAY: A4V04_12755
DAK: DaAHT2_0825
DSF: UWK_03162
DOL: Dole_2773 Dole_3184
DML: Dmul_30850(cdhC)
DAL: Dalk_0681
DAT: HRM2_16660(cdhC)
DTO: TOL2_C11810(cdhC)
DOV: DSCO28_59730
DWD: DSCW_28530
DALK: DSCA_26720
SFU: Sfum_2565
DAX: FDQ92_06240(cdhC)
DBR: Deba_0240
CSQ: CSCA_4551
CACE: CACET_c10320(acsB)
AMT: Amet_2028
BHAN: CGC63_07970(cdhC)
BLAU: DQQ01_09725(cdhC)
BLAB: EYS05_16725(cdhC)
PDC: CDIF630_00844(cdhC)
ROC: HF520_11260(cdhC)
DSY: DSY1652
ELM: ELI_3601
EMT: CPZ25_018715(cdhC)
AWO: Awo_c10760(acsB1) Awo_c33680(acsB2)
CTHM: CFE_1665
TKI: TKV_c19820(acsB)
CHY: CHY_1222(acsB)
MTA: Moth_1202
ADG: Adeg_0336
TPZ: Tph_c15170(acsA)
TOC: Toce_0813
EYY: EGYY_24100(CdhC)
DEH: cbdbA652(codH)
DEV: DhcVS_604(cdhC)
DMC: btf_622(acsB)
DMD: dcmb_668(acsB)
DMG: GY50_0591(cdhC)
DUC: UCH007_05840(acsB)
DFO: Dform_00887(acsB) Dform_00914(acsB)
KST: KSMBR1_1325(codh_acsB)
THET: F1847_08575(cdhC)
CTHI: THC_1762
TAV: G4V39_01655(cdhC)
TMAI: FVE67_00230(cdhC)
MMP: MMP0983(cdhB)
MMD: GYY_05740
MMAK: MMKA1_11390(cdhC)
MMAO: MMOS7_10750(cdhC)
MMAD: MMJJ_00080
MAE: Maeo_1171
METF: CFE53_00285(cdhC) CFE53_03765(cdhC)
MTH: MTH_1710
MMG: MTBMA_c02890(cdhC)
METC: MTCT_1563
MWO: MWSIV6_0251(cdhC)
METE: tca_01657
METK: FVF72_03115(cdhC)
MTHM: FZP57_01135(cdhC)
METH: MBMB1_1563(cdhC)
MFC: BRM9_0799(cdhC)
MFI: DSM1535_0761(cdhC)
MCUB: MCBB_1819(cdhC)
METT: CIT01_07280(cdhC)
METO: CIT02_10130(cdhC)
MFV: Mfer_0525
MKA: MK0720(cdhC)
AFU: AF_0379
MAC: MA_1014(cdhC) MA_3862(cdhC)
MTHR: MSTHT_2338
MTHE: MSTHC_0942
MFZ: AOB57_003745(cdhC)
MBU: Mbur_0860
MMET: MCMEM_0992
MMH: Mmah_1168
MPY: Mpsy_2893
MZI: HWN40_08235(cdhC)
MTP: Mthe_0290
MCJ: MCON_1330(cdhC) MCON_1942(cdhC)
MHU: Mhun_0688
MBG: BN140_2375(acsB)
MEMA: MMAB1_3162
MPL: Mpal_0803
RCI: LRC459(cdhC)
BARC: AOA65_0452(cdhC2)
BARB: AOA66_1430(cdhC2)
 » show all
Reference
1  [PMID:2984190]
  Authors
Ragsdale SW, Wood HG.
  Title
Acetate biosynthesis by acetogenic bacteria. Evidence that carbon monoxide dehydrogenase is the condensing enzyme that catalyzes the final steps of the synthesis.
  Journal
J Biol Chem 260:3970-7 (1985)
Reference
2  [PMID:12386327]
  Authors
Doukov TI, Iverson TM, Seravalli J, Ragsdale SW, Drennan CL.
  Title
A Ni-Fe-Cu center in a bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase.
  Journal
Science 298:567-72 (2002)
DOI:10.1126/science.1075843
  Sequence
[mta:Moth_1202]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.169
IUBMB Enzyme Nomenclature: 2.3.1.169
ExPASy - ENZYME nomenclature database: 2.3.1.169
BRENDA, the Enzyme Database: 2.3.1.169
CAS: 176591-19-8
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