KEGG   ENZYME: 2.3.1.176
Entry
EC 2.3.1.176                Enzyme                                 

Name
propanoyl-CoA C-acyltransferase;
SCP2 (gene name);
peroxisomal thiolase 2;
sterol carrier protein-chi;
SCPchi;
PTE-2 (ambiguous);
propionyl-CoA C2-trimethyltridecanoyltransferase;
3-oxopristanoyl-CoA hydrolase;
3-oxopristanoyl-CoA thiolase;
peroxisome sterol carrier protein thiolase;
sterol carrier protein;
oxopristanoyl-CoA thiolase;
peroxisomal 3-oxoacyl coenzyme A thiolase;
SCPx;
4,8,12-trimethyltridecanoyl-CoA:propanoyl-CoA 2-C-4,8,12-trimethyltridecanoyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA:propanoyl-CoA C-acyltransferase
Reaction(IUBMB)
3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA + propanoyl-CoA = CoA + 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA [RN:R03719]
Reaction(KEGG)
R03719 > R04811;
(other) R05330 R07937 R07953
Substrate
3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA [CPD:C01794];
propanoyl-CoA [CPD:C00100]
Product
CoA [CPD:C00010];
3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA [CPD:C05467]
Comment
Also acts on dihydroxy-5beta-cholestanoyl-CoA and other branched chain acyl-CoA derivatives. The enzyme catalyses the penultimate step in the formation of bile acids. The bile acid moiety is transferred from the acyl-CoA thioester (RCO-SCoA) to either glycine or taurine (NH2R') by EC 2.3.1.65, bile acid-CoA:amino acid N-acyltransferase [3].
History
EC 2.3.1.176 created 2005 (EC 2.3.1.154 created 2000, incorporated 2015)
Pathway
ec00120  Primary bile acid biosynthesis
ec01040  Biosynthesis of unsaturated fatty acids
ec01100  Metabolic pathways
Orthology
K08764  sterol carrier protein 2
Genes
HSA: 6342(SCP2)
PTR: 456862(SCP2)
PPS: 100986541(SCP2)
GGO: 101143883(SCP2)
PON: 100173072(SCP2)
NLE: 100597097(SCP2)
MCC: 715765(SCP2)
MCF: 102140312(SCP2)
CSAB: 103224800(SCP2)
RRO: 104669256(SCP2)
RBB: 108531191(SCP2)
CJC: 100388218(SCP2)
SBQ: 101036680(SCP2)
MMU: 20280(Scp2)
MCAL: 110292209(Scp2)
MPAH: 110323135(Scp2)
RNO: 25541(Scp2)
MUN: 110563883(Scp2)
CGE: 100757558(Scp2)
NGI: 103730241(Scp2)
HGL: 101705283(Scp2)
CCAN: 109693360(Scp2)
OCU: 100008683(SCP2)
TUP: 102487249(SCP2)
CFA: 479564(SCP2)
VVP: 112926124(SCP2)
AML: 100469567(SCP2)
UMR: 103670702(SCP2)
UAH: 113254655(SCP2)
ORO: 101367151(SCP2)
ELK: 111143445
FCA: 101093036(SCP2)
PTG: 102951550(SCP2)
PPAD: 109266864(SCP2)
AJU: 106987886(SCP2)
BTA: 508918(SCP2)
BOM: 102281973
BIU: 109556283(SCP2)
BBUB: 102409865(SCP2)
CHX: 102182369(SCP2)
OAS: 101117285(SCP2)
SSC: 397439(SCP2)
CFR: 102516689(SCP2)
CDK: 105090773(SCP2)
BACU: 103008562(SCP2)
LVE: 103081853
OOR: 101279314(SCP2)
DLE: 111175824(SCP2)
PCAD: 102988699(SCP2)
ECB: 100061338(SCP2)
EPZ: 103558615(SCP2)
EAI: 106833182(SCP2)
MYB: 102242920(SCP2)
MYD: 102765227(SCP2)
MNA: 107535398(SCP2)
DRO: 112314454(SCP2)
PALE: 102884769(SCP2)
RAY: 107497927(SCP2)
MJV: 108403979(SCP2)
LAV: 100666078
TMU: 101347488
MDO: 100017946(SCP2)
SHR: 100922562(SCP2)
PCW: 110209359(SCP2)
OAA: 100084202(SCP2)
GGA: 396550(SCP2)
MGP: 100541979(SCP2)
CJO: 107317654(SCP2)
NMEL: 110402526(SCP2)
APLA: 101803933(SCP2)
ACYG: 106032940(SCP2)
TGU: 100218387(SCP2)
LSR: 110470146(SCP2)
SCAN: 103815029(SCP2)
GFR: 102042799(SCP2)
FAB: 101820874(SCP2)
PHI: 102105546(SCP2)
PMAJ: 107208151(SCP2)
CCAE: 111933041(SCP2)
CCW: 104695523(SCP2)
ETL: 114062766(SCP2)
FPG: 101913645(SCP2)
FCH: 102053527(SCP2)
CLV: 102087499(SCP2)
EGZ: 104131500(SCP2)
ACUN: 113483071(SCP2)
PADL: 103913664(SCP2)
AAM: 106491062(SCP2)
AMJ: 102570791(SCP2)
PSS: 102461487(SCP2)
CMY: 102931842
CPIC: 101937963(SCP2)
ACS: 100559527(scp2)
PVT: 110082239(SCP2)
PBI: 103053379(SCP2)
PMUR: 107283044(SCP2)
TSR: 106546053(SCP2)
PMUA: 114598987(SCP2)
GJA: 107120559(SCP2)
XLA: 108715604 494715(scp2.L)
XTR: 548512(scp2)
NPR: 108783818(SCP2)
DRE: 393839(scp2a)
SRX: 107719264(scp2) 107722381
SANH: 107681719(scp2)
SGH: 107593851(scp2)
CCAR: 109091477
IPU: 108267621(scp2)
PHYP: 113540595
AMEX: 103022159(scp2)
EEE: 113570128(scp2)
TRU: 101069006(scp2)
LCO: 104936979(scp2)
NCC: 104949681(scp2)
MZE: 101481799(scp2)
ONL: 100711328
OLA: 101175107(scp2)
XMA: 102226285
XCO: 114145905(scp2)
PRET: 103479011(scp2)
CVG: 107083609(scp2)
NFU: 107384403
KMR: 108238206(scp2)
ALIM: 106527182(scp2)
AOCE: 111587618(scp2)
CSEM: 103395834(scp2)
POV: 109646608(scp2)
LCF: 108883814(scp2)
SDU: 111228861(scp2)
SLAL: 111670554(scp2)
HCQ: 109521343(scp2)
BPEC: 110173449(scp2) 110173461
MALB: 109970643(scp2)
SASA: 106569705(scp2)
OTW: 112260891(scp2)
SALP: 112069550
ELS: 105022798(scp2)
SFM: 108935159(scp2)
PKI: 111847545(scp2)
LCM: 102354489
CMK: 103185291(scp2)
RTP: 109913670(scp2)
APLC: 110986063
SKO: 100368127(SCP2) 100368276
DME: Dmel_CG17320(ScpX) Dmel_CG17597(CG17597)
DSI: Dsimw501_GD21807(Dsim_GD21807)
MDE: 101899830
LCQ: 111680181
AAG: 5575668
AME: 408904
BIM: 100748275
BTER: 100647066
CCAL: 108628439
OBB: 114870987
SOC: 105201416
MPHA: 105840706
AEC: 105153563
ACEP: 105618569
PBAR: 105432859
VEM: 105559618
HST: 105189995
DQU: 106742407
CFO: 105251216
LHU: 105675589
PGC: 109861339
OBO: 105274767
PCF: 106788866
NVI: 100123951
CSOL: 105363609
MDL: 103571215
TCA: 657233(Scpx)
DPA: 109539789
ATD: 109602926
NVL: 108556749
BMOR: 692782(Scpx)
BMAN: 114242327
PRAP: 110993930
HAW: 110373174
TNL: 113497353
PXY: 105382506
API: 100161454
DNX: 107161308
AGS: 114122268
RMD: 113555937
BTAB: 109035142
CLEC: 106670708
ZNE: 110831910
FCD: 110850871
PVM: 113823286
TUT: 107367461
CSCU: 111639045
CEL: CELE_Y57A10C.6(daf-22)
CBR: CBG20965
BMY: Bm1_53275
MYI: 110461537
OBI: 106877352
AMIL: 114970597
DGT: 114526215
AQU: 100638133
NCR: NCU03372
NTE: NEUTE1DRAFT84532(NEUTE1DRAFT_84532)
MGR: MGG_02409
SSCK: SPSK_02507
MAW: MAC_03561
MAJ: MAA_02626
MBE: MBM_04974
ANG: ANI_1_216184(An04g00740)
PBL: PAAG_11860(PAAG_04374)
ABE: ARB_01676
TVE: TRV_00032
PTE: PTT_11137
TASA: A1Q1_03740
ABP: AGABI1DRAFT110046(AGABI1DRAFT_110046)
ABV: AGABI2DRAFT190063(AGABI2DRAFT_190063)
SFR: Sfri_0743
CPS: CPS_0669
PSEO: OM33_12585
PSPO: PSPO_a2037
ADI: B5T_02065
APAC: S7S_16300
AXE: P40_09880
GPB: HDN1F_17110(tioL)
AAA: Acav_2987
HPSE: HPF_13290(paaJ2)
EBA: ebA306(tioL) ebA5797
TCL: Tchl_1577
PLA: Plav_0155
BRS: S23_06920
RPB: RPB_4078
RPD: RPD_3814
XAU: Xaut_4071
CAK: Caul_0450
SPSE: SULPSESMR1_04594(fadA)
SWI: Swit_4119
SMIC: SmB9_09260
AZL: AZL_a11110(fadA)
TMO: TMO_0975
MJL: Mjls_1512
MVQ: MYVA_4960
MCHT: MCHIJ_01810(ltp1_1)
ASD: AS9A_0934
NSR: NS506_04193(scp2)
GOR: KTR9_3195
 » show all
Reference
1  [PMID:7461136]
  Authors
Pedersen JI, Gustafsson J.
  Title
Conversion of 3 alpha, 7 alpha, 12 alpha-trihydroxy-5 beta-cholestanoic acid into cholic acid by rat liver peroxisomes.
  Journal
FEBS Lett 121:345-8 (1980)
DOI:10.1016/0014-5793(80)80377-2
Reference
2  [PMID:6668450]
  Authors
Kase F, Bjorkhem I, Pedersen JI.
  Title
Formation of cholic acid from 3 alpha, 7 alpha, 12 alpha-trihydroxy-5 beta-cholestanoic acid by rat liver peroxisomes.
  Journal
J Lipid Res 24:1560-7 (1983)
Reference
3  [PMID:8034703]
  Authors
Falany CN, Johnson MR, Barnes S, Diasio RB.
  Title
Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase.
  Journal
J Biol Chem 269:19375-9 (1994)
Reference
4  [PMID:8063752]
  Authors
Seedorf U, Brysch P, Engel T, Schrage K, Assmann G.
  Title
Sterol carrier protein X is peroxisomal 3-oxoacyl coenzyme A thiolase with intrinsic sterol carrier and lipid transfer activity.
  Journal
J Biol Chem 269:21277-83 (1994)
Reference
5  [PMID:9245689]
  Authors
Wanders RJ, Denis S, Wouters F, Wirtz KW, Seedorf U.
  Title
Sterol carrier protein X (SCPx) is a peroxisomal branched-chain beta-ketothiolase specifically reacting with 3-oxo-pristanoyl-CoA: a new, unique role for SCPx in branched-chain fatty acid metabolism in peroxisomes.
  Journal
Biochem Biophys Res Commun 236:565-9 (1997)
DOI:10.1006/bbrc.1997.7007
Reference
6  [PMID:12543708]
  Authors
Russell DW.
  Title
The enzymes, regulation, and genetics of bile acid synthesis.
  Journal
Annu Rev Biochem 72:137-74 (2003)
DOI:10.1146/annurev.biochem.72.121801.161712
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.176
IUBMB Enzyme Nomenclature: 2.3.1.176
ExPASy - ENZYME nomenclature database: 2.3.1.176
BRENDA, the Enzyme Database: 2.3.1.176
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