Entry |
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Name |
lauroyl-Kdo2-lipid IVA myristoyltransferase;
MsbB acyltransferase;
lpxM (gene name);
myristoyl-[acyl-carrier protein]:alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(dodecanoyl)-lipid IVA O-myristoyltransferase
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Class |
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
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Sysname |
tetradecanoyl-[acyl-carrier protein]:dodecanoyl-Kdo2-lipid IVA O-tetradecanoyltransferase
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Reaction(IUBMB) |
a tetradecanoyl-[acyl-carrier protein] + dodecanoyl-Kdo2-lipid IVA = dodecanoyl-(tetradecanoyl)-Kdo2-lipid IVA + an [acyl-carrier protein] [RN: R05075]
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Reaction(KEGG) |
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Substrate |
tetradecanoyl-[acyl-carrier protein] [CPD: C05761];
dodecanoyl-Kdo2-lipid IV(A) [CPD: C06251]
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Product |
dodecanoyl-(tetradecanoyl)-Kdo2-lipid IV(A) [CPD: C06026];
[acyl-carrier protein] [CPD: C00229]
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Comment |
The enzyme, characterized from the bacterium Escherichia coli, is involved in the biosynthesis of the phosphorylated outer membrane glycolipid lipid A.
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History |
EC 2.3.1.243 created 2014
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Pathway |
ec00540 | Lipopolysaccharide biosynthesis |
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Orthology |
K02560 | lauroyl-Kdo2-lipid IVA myristoyltransferase |
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Genes |
» show all
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Reference |
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Authors |
Clementz T, Zhou Z, Raetz CR |
Title |
Function of the Escherichia coli msbB gene, a multicopy suppressor of htrB knockouts, in the acylation of lipid A. Acylation by MsbB follows laurate incorporation by HtrB. |
Journal |
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Sequence |
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Other DBs |
ExPASy - ENZYME nomenclature database: | 2.3.1.243 |
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LinkDB |
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