KEGG   ENZYME: 2.3.1.279Help
Entry
EC 2.3.1.279                Enzyme                                 

Name
long-chain-acyl-CoA---trehalose acyltransferase;
papA3 (gene name)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
long-chain-fatty acyl-CoA:alpha,alpha-trehalose 2-acyltransferase
Reaction(IUBMB)
a long-chain-fatty acyl-CoA + alpha,alpha-trehalose = a 2-(long-chain-fatty acyl)-trehalose + CoA [RN:R12287]
Reaction(KEGG)
Substrate
long-chain-fatty acyl-CoA;
alpha,alpha-trehalose [CPD:C01083]
Product
2-(long-chain-fatty acyl)-trehalose [CPD:C22061];
CoA [CPD:C00010]
Comment
The enzyme, characterized from the bacterium Mycobacterium tuberculosis, participates in the biosynthesis of polyacyltrehalose (PAT), a pentaacylated, trehalose-based glycolipid found in the cell wall of pathogenic strains. The enzyme catalyses two successive activities - it first transfers an acyl (often palmitoyl) group to position 2, followed by the transfer of a mycolipenyl group to position 3 (see EC 2.3.1.278, mycolipenoyl-CoA---2-(long-chain-fatty acyl)-trehalose mycolipenoyltransferase).
History
EC 2.3.1.279 created 2018
Orthology
K23156  mycolipenoyl-CoA---2-(long-chain-fatty acyl)-trehalose mycolipenoyltransferase / long-chain-acyl-CoA---trehalose acyltransferase
Genes
MTU: Rv1182(papA3)
MTV: RVBD_1182
MTC: MT1219
MRA: MRA_1192(papA3)
MTF: TBFG_11206
MTB: TBMG_02800
MTK: TBSG_02814
MTZ: TBXG_002780
MTG: MRGA327_07450
MTE: CCDC5079_1093
MTUR: CFBS_1260(papA3)
MTO: MTCTRI2_1213(papA3)
MTD: UDA_1182(papA3)
MTN: ERDMAN_1324(papA3)
MTUC: J113_08295
MTUE: J114_06385
MTUH: I917_08405
MTUL: TBHG_01165
MTUT: HKBT1_1258(papA3)
MTUU: HKBT2_1264(papA3)
MTQ: HKBS1_1262(papA3)
MBO: BQ2027_MB1214(papA3)
MBB: BCG_1244(papA3)
MBT: JTY_1217(papA3)
MBM: BCGMEX_1216(papA3)
MBX: BCGT_1013
MAF: MAF_12010(papA3)
MMIC: RN08_1326
MCE: MCAN_11931(papA3)
MCQ: BN44_11321(papA)
MCV: BN43_30249(papA)
MCX: BN42_21047(papA)
MCZ: BN45_30244(papA)
MLE: ML1230(papA3)
MLB: MLBr01230(papA3)
MPA: MAP_2231(papA3) MAP_3721 MAP_3763c(papA3)
MLP: MLM_2749
MUL: MUL_1531(papA3)
MMI: MMAR_2343 MMAR_2355(papA3)
MLI: MULP_03269(papA3)
MSG: MSMEI_0399(papA3) MSMEI_4611
MVA: Mvan_0270
MGI: Mflv_0404
MPHL: MPHLCCUG_00973(papA3_1) MPHLCCUG_04852(papA3_2)
MVQ: MYVA_0272
MTHN: 4412656_01985(papA1)
MSAL: DSM43276_00716(papA2) DSM43276_00773(papA3_1) DSM43276_02932(papA3_2)
RHS: A3Q41_03341(papA3_3)
GOM: D7316_01432(papA1_1)
LMOI: VV02_01885
 » show all
Taxonomy
Reference
1  [PMID:19276083]
  Authors
Hatzios SK, Schelle MW, Holsclaw CM, Behrens CR, Botyanszki Z, Lin FL, Carlson BL, Kumar P, Leary JA, Bertozzi CR
  Title
PapA3 is an acyltransferase required for polyacyltrehalose biosynthesis in Mycobacterium tuberculosis.
  Journal
J Biol Chem 284:12745-51 (2009)
DOI:10.1074/jbc.M809088200
  Sequence
[mtu:Rv1182]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.279
IUBMB Enzyme Nomenclature: 2.3.1.279
ExPASy - ENZYME nomenclature database: 2.3.1.279
BRENDA, the Enzyme Database: 2.3.1.279
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