KEGG   ENZYME: 2.3.1.279
Entry
EC 2.3.1.279                Enzyme                                 

Name
long-chain-acyl-CoA---trehalose acyltransferase;
papA3 (gene name)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
long-chain-fatty acyl-CoA:alpha,alpha-trehalose 2-acyltransferase
Reaction(IUBMB)
a long-chain-fatty acyl-CoA + alpha,alpha-trehalose = a 2-(long-chain-fatty acyl)-trehalose + CoA [RN:R12287]
Reaction(KEGG)
R12287
Substrate
long-chain-fatty acyl-CoA;
alpha,alpha-trehalose [CPD:C01083]
Product
2-(long-chain-fatty acyl)-trehalose [CPD:C22061];
CoA [CPD:C00010]
Comment
The enzyme, characterized from the bacterium Mycobacterium tuberculosis, participates in the biosynthesis of polyacyltrehalose (PAT), a pentaacylated, trehalose-based glycolipid found in the cell wall of pathogenic strains. The enzyme catalyses two successive activities - it first transfers an acyl (often palmitoyl) group to position 2, followed by the transfer of a mycolipenyl group to position 3 (see EC 2.3.1.278, mycolipenoyl-CoA---2-(long-chain-fatty acyl)-trehalose mycolipenoyltransferase).
History
EC 2.3.1.279 created 2018
Orthology
K23156  mycolipenoyl-CoA---2-(long-chain-fatty acyl)-trehalose mycolipenoyltransferase / long-chain-acyl-CoA---trehalose acyltransferase
Genes
LBQ: CKQ53_00740
ZPL: ZBT109_1554
CTI: pRALTA_0573
SAME: SAMCFNEI73_pB0404
BSYM: CIT39_22775
MTU: Rv1182(papA3)
MTV: RVBD_1182
MTC: MT1219
MRA: MRA_1192(papA3)
MTF: TBFG_11206
MTUR: CFBS_1260(papA3)
MTO: MTCTRI2_1213(papA3)
MTD: UDA_1182(papA3)
MTN: ERDMAN_1324(papA3)
MTUC: J113_08295
MTUE: J114_06385
MTUH: I917_08405
MTUL: TBHG_01165
MTUT: HKBT1_1258(papA3)
MTUU: HKBT2_1264(papA3)
MTQ: HKBS1_1262(papA3)
MBO: BQ2027_MB1214(papA3)
MBB: BCG_1244(papA3)
MBT: JTY_1217(papA3)
MBM: BCGMEX_1216(papA3)
MBX: BCGT_1013
MAF: MAF_12010(papA3)
MMIC: RN08_1326
MCE: MCAN_11931(papA3)
MCQ: BN44_11321(papA)
MCV: BN43_30249(papA)
MCX: BN42_21047(papA)
MCZ: BN45_30244(papA)
MLE: ML1230(papA3)
MLB: MLBr01230(papA3)
MPA: MAP_2231(papA3) MAP_3721 MAP_3763c(papA3)
MLP: MLM_2749
MUL: MUL_1531(papA3)
MLI: MULP_00074 MULP_03269(papA3)
MSHG: MSG_03264 MSG_03826(papA3)
MSG: MSMEI_0399(papA3) MSMEI_4611
MVA: Mvan_0270
MGI: Mflv_0404
MPHL: MPHLCCUG_00973(papA3_1) MPHLCCUG_04852(papA3_2)
MVQ: MYVA_0272
MTHN: 4412656_01985(papA1)
MSAL: DSM43276_00716(papA2) DSM43276_00773(papA3_1) DSM43276_02932(papA3_2)
MMIN: MMIN_17130(papA3)
CVA: CVAR_2563
CTER: A606_10850
REQ: REQ_33910
RFA: A3L23_00070(papA3_1) A3L23_00075(papA3_3)
RHS: A3Q41_02149(papA3_1) A3Q41_03338(papA3_2) A3Q41_03343(papA3_4)
RHU: A3Q40_02056(papA3_1) A3Q40_02058(papA2) A3Q40_02063(papA3_2)
RCR: NCTC10994_03880(papA2)
GBR: Gbro_1833
GRU: GCWB2_04595(papA1) GCWB2_08990(papA4)
GOM: D7316_01431(papA3_1) D7316_01433(papA1_2) D7316_01436(papA3_2) D7316_01834(papA3_3) D7316_01836(papA3_4)
SHY: SHJG_5667
SRW: TUE45_05074(papA2)
STRD: NI25_16465
SALJ: SMD11_2920
SRJ: SRO_3188
SERJ: SGUI_2570
PSEA: WY02_28115
PSEH: XF36_14880
 » show all
Reference
1  [PMID:19276083]
  Authors
Hatzios SK, Schelle MW, Holsclaw CM, Behrens CR, Botyanszki Z, Lin FL, Carlson BL, Kumar P, Leary JA, Bertozzi CR
  Title
PapA3 is an acyltransferase required for polyacyltrehalose biosynthesis in Mycobacterium tuberculosis.
  Journal
J Biol Chem 284:12745-51 (2009)
DOI:10.1074/jbc.M809088200
  Sequence
[mtu:Rv1182]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.279
IUBMB Enzyme Nomenclature: 2.3.1.279
ExPASy - ENZYME nomenclature database: 2.3.1.279
BRENDA, the Enzyme Database: 2.3.1.279
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