KEGG   ENZYME: 2.3.1.286Help
Entry
EC 2.3.1.286                Enzyme                                 

Name
protein acetyllysine N-acetyltransferase;
Sir2;
protein lysine deacetylase;
NAD+-dependent protein deacetylase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
[protein]-N6-acetyl-L-lysine:NAD+ N-acetyltransferase (NAD+-hydrolysing; 2''-O-acetyl-ADP-D-ribose-forming)
Reaction(IUBMB)
[protein]-N6-acetyl-L-lysine + NAD+ + H2O = [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide (overall reaction) [RN:R10634];
(1a) [protein]-N6-acetyl-L-lysine + NAD+ = [protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + nicotinamide;
(1b) [protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + H2O = [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose
Reaction(KEGG)
Substrate
[protein]-N6-acetyl-L-lysine [CPD:C20743];
NAD+ [CPD:C00003];
H2O [CPD:C00001];
[protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine
Product
[protein]-L-lysine [CPD:C02188];
2''-O-acetyl-ADP-D-ribose;
nicotinamide [CPD:C00153];
[protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine
Comment
The enzyme, found in all domains of life, is involved in gene regulation by deacetylating proteins. Some of the 2''-O-acetyl-ADP-D-ribose converts non-enzymically to 3''-O-acetyl-ADP-D-ribose.
History
EC 2.3.1.286 created 2019
Pathway
ec00760  Nicotinate and nicotinamide metabolism
ec01100  Metabolic pathways
Orthology
K11121  NAD+-dependent protein deacetylase SIR2
K11411  NAD+-dependent protein deacetylase sirtuin 1
K11412  NAD+-dependent protein deacetylase sirtuin 2
K11413  NAD+-dependent protein deacetylase sirtuin 3
K11414  NAD+-dependent protein deacetylase sirtuin 4
K11415  NAD+-dependent protein deacetylase sirtuin 5
K11416  NAD+-dependent protein deacetylase sirtuin 6
K11417  NAD+-dependent protein deacetylase sirtuin 7
Genes
HSA: 22933(SIRT2) 23408(SIRT5) 23409(SIRT4) 23410(SIRT3) 23411(SIRT1) 51547(SIRT7) 51548(SIRT6)
PTR: 107966703(SIRT1) 450911(SIRT3) 454975(SIRT7) 456013(SIRT2) 737026(SIRT6) 742235(SIRT4) 747069(SIRT5)
PPS: 100971688(SIRT4) 100973326(SIRT3) 100979564(SIRT2) 100981638(SIRT7) 100984983(SIRT1) 100985261(SIRT5) 100995305(SIRT6)
GGO: 101126809(SIRT3) 101127624(SIRT6) 101130710(SIRT4) 101144438(SIRT7) 101146991(SIRT5) 101147879(SIRT1) 101148685(SIRT2)
PON: 100172430(SIRT2) 100189679(SIRT5) 100441394(SIRT6) 100443901(SIRT1) 100445616(SIRT4) 100453970(SIRT3) 100454765(SIRT7)
NLE: 100582821(SIRT5) 100586803(SIRT4) 100592506(SIRT6) 100593210(SIRT7) 100599033(SIRT2) 100604320(SIRT3) 100605499(SIRT1)
MCC: 100425019(SIRT2) 695682(SIRT1) 700855(SIRT5) 714545(SIRT6) 715069(SIRT7) 720498(SIRT4) 720737(SIRT3)
MCF: 101865690(SIRT2) 102134009(SIRT1) 102138500(SIRT5) 102138867(SIRT4) 102141105(SIRT7) 102141535(SIRT6) 102142238(SIRT3)
CSAB: 103216104(SIRT1) 103222143(SIRT5) 103233715(SIRT6) 103234644(SIRT2) 103234991(SIRT3) 103239246(SIRT4) 103243740(SIRT7)
RRO: 104654972(SIRT7) 104665427(SIRT6) 104666248(SIRT4) 104671788(SIRT1) 104672592(SIRT5) 104672643(SIRT3) 104676170(SIRT2)
RBB: 108512132(SIRT6) 108514897(SIRT1) 108533998(SIRT4) 108534099(SIRT7) 108538000(SIRT3) 108539022(SIRT2) 108541593(SIRT5)
CJC: 100386098(SIRT3) 100393634(SIRT2) 100394706(SIRT6) 100395149(SIRT1) 100399307(SIRT7) 100405511(SIRT4) 100409461(SIRT5)
SBQ: 101028915(SIRT2) 101029573(SIRT1) 101037109(SIRT6) 101046747(SIRT7) 101050089(SIRT3) 101051064(SIRT5) 101053646(SIRT4)
MMU: 209011(Sirt7) 50721(Sirt6) 64383(Sirt2) 64384(Sirt3) 68346(Sirt5) 75387(Sirt4) 93759(Sirt1)
MCAL: 110294568(Sirt4) 110297295(Sirt2) 110297529(Sirt3) 110303259(Sirt6) 110303892(Sirt1) 110305783(Sirt7) 110308397(Sirt5)
MPAH: 110313125(Sirt4) 110319971(Sirt2) 110326146(Sirt6) 110326468(Sirt1) 110331620(Sirt7) 110333965(Sirt5) 110334277(Sirt3)
RNO: 293615(Sirt3) 299638(Sirt6) 303745(Sirt7) 304539(Sirt4) 306840(Sirt5) 309757(Sirt1) 361532(Sirt2)
MUN: 110544304(Sirt5) 110545594(Sirt4) 110548526(Sirt6) 110548838(Sirt7) 110552523(Sirt2) 110553899(Sirt3) 110554873(Sirt1)
CGE: 100756695(Sirt4) 100757186(Sirt7) 100760117(Sirt6) 100762304(Sirt3) 100763298(Sirt1) 100767069(Sirt5) 100768923(Sirt2)
NGI: 103730192(Sirt7) 103732881(Sirt5) 103733767(Sirt1) 103737237(Sirt6) 103739986(Sirt4) 103750724(Sirt2) 103751056(Sirt3)
HGL: 101697494(Sirt3) 101700255(Sirt4) 101706114(Sirt6) 101715152(Sirt2) 101716210(Sirt7) 101718891(Sirt5) 101720282(Sirt1)
CCAN: 109681555(Sirt1) 109685517 109685520(Sirt5) 109687811(Sirt6) 109691498(Sirt3) 109695820(Sirt2) 109696165(Sirt4) 109702732(Sirt7)
OCU: 100337887(SIRT2) 100339154(SIRT5) 100349271(SIRT1) 100353055(SIRT4) 100354500(SIRT3)
TUP: 102471182(SIRT5) 102475139(SIRT6) 102484296(SIRT1) 102495546(SIRT7) 102497077(SIRT2) 102500441(SIRT4) 102502361(SIRT3)
CFA: 475933(SIRT3) 477507(SIRT4) 478726(SIRT5) 483371(SIRT7) 485045(SIRT6) 489012(SIRT1) 612558(SIRT2)
VVP: 112914416(SIRT3) 112920537(SIRT5) 112920905(SIRT7) 112927672(SIRT1) 112928185 112928407(SIRT2) 112932880(SIRT4) 112935584(SIRT6)
AML: 100467019(SIRT2) 100468963(SIRT3) 100469747(SIRT5) 100470238(SIRT7) 100473744(SIRT4) 100483389(SIRT6) 100484328(SIRT1)
UMR: 103661014(SIRT2) 103664900(SIRT5) 103666002(SIRT7) 103667762(SIRT1) 103671025(SIRT3) 103678329(SIRT4) 103681835(SIRT6)
UAH: 113242824(SIRT6) 113243599(SIRT2) 113244493(SIRT7) 113248769(SIRT3) 113259105(SIRT1) 113264471(SIRT5) 113267037(SIRT4)
ORO: 101369393(SIRT4) 101370518(SIRT3) 101376010(SIRT6) 101376632(SIRT7) 101381670(SIRT5) 101382490(SIRT1) 101386846(SIRT2)
FCA: 101087609(SIRT3) 101087610(SIRT1) 101089862(SIRT5) 101095286(SIRT4) 101099513(SIRT2) 101100540(SIRT6) 101100681(SIRT7)
PTG: 102948519(SIRT2) 102948876(SIRT3) 102949922(SIRT5) 102953638(SIRT4) 102956235(SIRT6) 102963908(SIRT1) 102972924(SIRT7)
PPAD: 109249621(SIRT5) 109255941(SIRT6) 109256621(SIRT2) 109259795(SIRT3) 109264323(SIRT1) 109276764(SIRT7) 109277540(SIRT4)
AJU: 106967135(SIRT1) 106971692(SIRT4) 106974181(SIRT5) 106975501(SIRT6) 106986346(SIRT7) 106987944(SIRT3) 106988309(SIRT2)
BTA: 504463(SIRT2) 505662(SIRT7) 507347(SIRT5) 519328(SIRT4) 535416(SIRT6) 613629(SIRT1) 614027(SIRT3)
BOM: 102266352(SIRT4) 102272282(SIRT6) 102274743(SIRT3) 102276604(SIRT1) 102280522(SIRT5) 102284477(SIRT2) 102287843(SIRT7)
BIU: 109553808(SIRT1) 109561749(SIRT6) 109571484(SIRT4) 109572599(SIRT2) 109573911(SIRT7) 109577246(SIRT5)
BBUB: 102396347(SIRT4) 102400024(SIRT6) 102403716(SIRT3) 102404018(SIRT7) 102408248(SIRT2) 102409911(SIRT1) 102411275(SIRT5)
CHX: 100860989(SIRT5) 102168297(SIRT7) 102171640(SIRT4) 102174381(SIRT6) 102180824(SIRT1) 102181151(SIRT2) 102181661(SIRT3)
OAS: 100217404(SIRT4) 101102956(SIRT1) 101104099(SIRT5) 101105454(SIRT3) 101108066(SIRT7) 101113169(SIRT2) 101113327(SIRT6)
SSC: 100125349(SIRT4) 100125964(SIRT2) 100125965(SIRT7) 100125966(SIRT5) 100125971(SIRT3) 100126274(SIRT6) 751859(SIRT1)
CFR: 102507714(SIRT7) 102509749(SIRT5) 102512075(SIRT3) 102515768(SIRT1) 102517594(SIRT4) 102519858(SIRT6) 102522802(SIRT2)
CDK: 105089089(SIRT5) 105093303(SIRT2) 105093901(SIRT1) 105102000(SIRT4) 105105304(SIRT6) 105105732(SIRT3) 105106386(SIRT7)
BACU: 103009522(SIRT4) 103011001(SIRT1) 103011694(SIRT3) 103016517(SIRT2) 103017769(SIRT6) 103018550(SIRT5) 103018701(SIRT7)
LVE: 103072883(SIRT5) 103073899(SIRT3) 103075387(SIRT2) 103079453(SIRT4) 103080304(SIRT1) 103081341(SIRT7) 103091498(SIRT6)
OOR: 101276018(SIRT5) 101276270(SIRT7) 101279007(SIRT1) 101280224(SIRT2) 101282853(SIRT4) 101287669(SIRT6) 101288599(SIRT3)
DLE: 111162771(SIRT4) 111166196(SIRT6) 111170308(SIRT3) 111180885(SIRT2) 111181373(SIRT5) 111182686(SIRT7) 111183434(SIRT1)
PCAD: 102974598(SIRT4) 102983232(SIRT7) 102989179(SIRT6) 102992890 102993364(SIRT1) 102995091(SIRT2) 114485288
ECB: 100051757(SIRT5) 100053520(SIRT4) 100054908(SIRT3) 100054966(SIRT7) 100063125(SIRT6) 100072571(SIRT1) 100146611(SIRT2)
EPZ: 103539966(SIRT3) 103540609(SIRT4) 103545290(SIRT6) 103551120(SIRT7) 103551671(SIRT5) 103562180(SIRT1) 103564559(SIRT2)
EAI: 106832324(SIRT6) 106836076(SIRT2) 106836560(SIRT5) 106843865(SIRT3) 106844401 106844414(SIRT1) 106844786(SIRT4) 106845950(SIRT7)
MYB: 102240165(SIRT1) 102243773 102244974(SIRT6) 102248315(SIRT7) 102252773(SIRT3) 102255057(SIRT4) 102260946(SIRT5) 102261472(SIRT2)
MYD: 102753056(SIRT5) 102756748(SIRT1) 102757008(SIRT6) 102759133(SIRT7) 102769161(SIRT2) 102770304(SIRT4)
MNA: 107525642(SIRT6) 107526052(SIRT1) 107528504(SIRT4) 107532201(SIRT2) 107539061(SIRT7) 107540371(SIRT5) 107544448(SIRT3)
HAI: 109371987(SIRT1) 109378085(SIRT3) 109386137(SIRT4) 109388637(SIRT6) 109393057(SIRT7) 109393189(SIRT5) 109395378(SIRT2)
DRO: 112298721(SIRT7) 112305485(SIRT1) 112309324(SIRT5) 112310838(SIRT4) 112312652(SIRT6) 112317110(SIRT3) 112320128(SIRT2)
PALE: 102880351(SIRT1) 102882055(SIRT2) 102887102(SIRT3) 102888316(SIRT4) 102888412(SIRT7) 102893459(SIRT6) 102893890(SIRT5)
RAY: 107499254(SIRT5) 107501263(SIRT4) 107501303(SIRT1) 107506500(SIRT3) 107510665(SIRT6) 107520265(SIRT7) 107520972(SIRT2)
MJV: 108384848(SIRT3) 108385044(SIRT6) 108395248(SIRT7) 108395443(SIRT2) 108397704(SIRT4) 108407546(SIRT1) 108409410(SIRT5)
LAV: 100654664(SIRT3) 100660519(SIRT2) 100667672(SIRT1) 100670842(SIRT4) 100670854(SIRT6) 100671587(SIRT5) 100675031(SIRT7)
MDO: 100013652(SIRT2) 100015574(SIRT1) 100022578(SIRT6) 100026454(SIRT5) 100030060(SIRT7) 100030763(SIRT3)
SHR: 100917917(SIRT6) 100919915(SIRT5) 100920789(SIRT4) 100920847(SIRT1) 100924073(SIRT3) 100924923(SIRT2) 100925189 111720562
PCW: 110197475(SIRT6) 110202303(SIRT2) 110203709(SIRT3) 110208679(SIRT5) 110216385(SIRT1) 110218300(SIRT7) 110222838(SIRT4)
OAA: 100077037(SIRT1) 100084511(SIRT5) 100088272(SIRT4) 100089118(SIRT3) 100091769(SIRT6) 103166548(SIRT2) 103167172(SIRT7)
GGA: 103214197(SIRT7) 416981(SIRT4) 420834(SIRT5) 422988(SIRT3) 423646(SIRT1) 428332(SIRT6) 548628(SIRT2)
MGP: 100538676(SIRT3) 100540948(SIRT1) 100543343 100543638(SIRT4) 100545598(SIRT7) 100548081(SIRT5) 100550109(SIRT6)
CJO: 107309713(SIRT5) 107314282(SIRT3) 107315730(SIRT1) 107321416(SIRT4) 107322164(SIRT7) 107325598(SIRT6)
NMEL: 110388856(SIRT6) 110389127(SIRT2) 110394208(SIRT5) 110399426(SIRT1) 110401506(SIRT3) 110406420(SIRT4) 110407495(SIRT7)
APLA: 101790245(SIRT4) 101793845(SIRT5) 101794570(SIRT3) 101799275(SIRT1) 101800216(SIRT7)
ACYG: 106031113(SIRT1) 106031357(SIRT4) 106041701(SIRT5) 106044948(SIRT6) 106046758(SIRT7) 106047042(SIRT3)
TGU: 100218013(SIRT4) 100220330(SIRT5) 100225810(SIRT3) 100228792(SIRT7) 100229233(SIRT1) 100230927(SIRT6)
LSR: 110467555(SIRT3) 110469870(SIRT1) 110472465(SIRT7) 110478471(SIRT6) 110478778(SIRT2) 110481279(SIRT4) 110483427(SIRT5)
SCAN: 103818255(SIRT4) 103819409(SIRT5) 103819914(SIRT7) 103821200(SIRT1) 103824554(SIRT6) 103826814(SIRT3)
GFR: 102031922 102032305(SIRT7) 102033998(SIRT5) 102035189(SIRT3) 102038978(SIRT1) 102040813(SIRT6) 102045130(SIRT4)
FAB: 101806071(SIRT4) 101810475(SIRT1) 101814833(SIRT6) 101820436(SIRT7) 101820797(SIRT5) 101821658(SIRT3)
PHI: 102099591(SIRT7) 102100758(SIRT2) 102100972(SIRT5) 102101925(SIRT6) 102101980(SIRT1) 102106576(SIRT3) 102109781(SIRT4)
PMAJ: 107199375(SIRT2) 107199842(SIRT5) 107205276(SIRT3) 107206664(SIRT1) 107211601(SIRT4) 107212419(SIRT7) 107215472(SIRT6)
CCAE: 111923925 111930585(SIRT3) 111931513(SIRT1) 111936753(SIRT4) 111937593(SIRT7) 111940202(SIRT6) 111944708
CCW: 104684530(SIRT3) 104688535(SIRT4) 104690233(SIRT1) 104691427 104697408(SIRT6) 104698225(SIRT7)
ETL: 114056613(SIRT4) 114059470(SIRT5) 114060345(SIRT7) 114063308(SIRT3) 114064018(SIRT1) 114068845(SIRT6) 114071415(SIRT2)
FPG: 101912373(SIRT4) 101912911(SIRT1) 101914765(SIRT3) 101915536(SIRT7) 101915619(SIRT5) 101924635(SIRT6)
FCH: 102049786(SIRT3) 102053599(SIRT4) 102058467(SIRT1) 102060061(SIRT5)
CLV: 102083548(SIRT4) 102087231(SIRT7) 102089394(SIRT3) 102091510(SIRT1) 102093099 102096880(SIRT6)
EGZ: 104124399(SIRT6) 104124613(SIRT1) 104125486(SIRT5) 104127879(SIRT3) 104129897(SIRT4) 104131205(SIRT7)
NNI: 104011402(SIRT3) 104011505(SIRT4) 104013536(SIRT1) 104014384(SIRT7) 104018755(SIRT6) 104021805(SIRT5)
ACUN: 113477336(SIRT5) 113481210(SIRT3) 113481816(SIRT1) 113486158(SIRT4) 113486984(SIRT7) 113489425(SIRT6)
PADL: 103916494(SIRT6) 103917462(SIRT7) 103918614(SIRT1) 103919047(SIRT5) 103922636(SIRT4) 103925062(SIRT3)
AAM: 106483417(SIRT5) 106486338(SIRT4) 106486965(SIRT1) 106487099(SIRT7) 106489140(SIRT3) 106491452 106492200(SIRT6)
ASN: 102369643(SIRT1) 102369809(SIRT4) 102370553(SIRT5) 102374793(SIRT6) 102382706(SIRT7) 102384882(SIRT3) 102385173(SIRT2)
AMJ: 102558286(SIRT4) 102558981(SIRT6) 102560050(SIRT2) 102561292(SIRT1) 102562277(SIRT3) 102562811(SIRT7) 102570727(SIRT5)
PSS: 102444070(SIRT2) 102446525(SIRT1) 102456117(SIRT7) 102457485(SIRT3) 102457582(SIRT6) 102459170(SIRT4) 102463555(SIRT5)
CMY: 102930541(SIRT1) 102931061(SIRT5) 102931128(SIRT6) 102931534(SIRT4) 102933136(SIRT2) 102935907(SIRT3) 102937509(SIRT7)
CPIC: 101933048(SIRT3) 101935658(SIRT1) 101936381(SIRT5) 101937028(SIRT7) 101938056(SIRT6) 101940801(SIRT4) 101948487(SIRT2)
ACS: 100552312(sirt7) 100555746(sirt4) 100555836(sirt3) 100559366(sirt2) 100562942(sirt5) 100564010(sirt1) 103283007(sirt6)
PVT: 110072467(SIRT6) 110075685(SIRT2) 110081688(SIRT5) 110081924(SIRT4) 110086196(SIRT3) 110087595(SIRT1) 110090620(SIRT7)
PBI: 103051631(SIRT5) 103053168(SIRT4) 103054603(SIRT1) 103058243(SIRT2) 103063418(SIRT7) 103067152(SIRT3) 103068171(SIRT6)
PMUR: 107286340(SIRT5) 107287021 107288080(SIRT1) 107294411(SIRT7) 107294462(SIRT3) 107295322(SIRT6) 107297307(SIRT2) 107300028(SIRT4) 107300980
TSR: 106539436(SIRT1) 106544757(SIRT6) 106547544(SIRT4) 106547596(SIRT3) 106547979(SIRT5) 106555160(SIRT7)
PMUA: 114586680(SIRT4) 114588457(SIRT6) 114589553(SIRT7) 114597181(SIRT1) 114600420(SIRT3) 114600869(SIRT5) 114603233(SIRT2)
GJA: 107106244(SIRT5) 107112732(SIRT3) 107118137(SIRT7) 107118231(SIRT6) 107120476(SIRT1) 107121997(SIRT2) 107126098(SIRT4)
XLA: 100036963(sirt1.L) 100037190 108697451(sirt1.S) 108708898 108715195(sirt3.1.S) 414591(sirt4.L) 444018(sirt6.S) 447308(sirt5.S) 495235(sirt7.L) 495688(sirt2.S) 496346(sirt5.L) 734623(sirt3.2.L)
XTR: 100145679(sirt1) 100145681(sirt3.2) 100170199(sirt5) 100487410(sirt3.1) 100489469(sirt2) 394980(sirt6) 548532(sirt7) 733911(sirt4)
NPR: 108784742(SIRT7) 108787683(SIRT2) 108787963 108792801(SIRT5) 108795891 108800096(SIRT4) 108801625(SIRT1) 108801678(SIRT6)
DRE: 322309(sirt2) 415161(sirt6) 436878(sirt5) 557125(si:dkey-103i16.6) 558775(sirt3) 791628(sirt4) 796135(sirt7) 797132(sirt1)
IPU: 100528250(sirt5) 108261052(sirt1) 108264662 108268057 108270905(sirt7) 108270931(sirt3) 108272083(sirt4) 108280670(sirt2) 108280862(sirt6)
PHYP: 113533504(sirt6) 113534831 113536446(sirt7) 113536463(sirt3) 113539874(sirt4) 113542038(sirt1) 113543155(sirt2) 113545351(sirt5) 113547299
AMEX: 103031674(sirt1) 103031700(sirt5) 103035964(sirt7) 103038996(sirt2) 103041182(sirt4) 103043515 103044645(sirt3) 111194338 111194539(sirt6)
EEE: 113567518(sirt1) 113575974(sirt4) 113577770(sirt7) 113578364(sirt3) 113582991 113584652(sirt2) 113588649(sirt5) 113589963 113591059(sirt6)
TRU: 101061405(sirt1) 101061516(sirt7) 101066119 101067563(sirt3) 101073832(sirt2) 101074434(sirt5) 101075845(sirt4) 101077590(sirt6)
NCC: 104948251 104948858(sirt4) 104950018(sirt7) 104952063 104954072 104962438(sirt5) 104964220(sirt6) 104964612(sirt1) 104965729(sirt3)
MZE: 101466609(sirt5) 101471570 101474545(sirt3) 101476082 101479228(sirt4) 101480414(sirt1) 101481317(sirt6) 101486918(sirt7) 101487109(sirt2)
ONL: 100690476(sirt2) 100692411 100693812(sirt3) 100698520(sirt4) 100700228(sirt7) 100700447(sirt1) 100701603 100703113(sirt5) 100709302(sirt6) 109198075
OLA: 101155450(sirt2) 101156229(sirt7) 101156953(sirt4) 101161471(sirt3) 101162440(sirt5) 101163111 101165477 101171032(sirt6) 101175344(sirt1)
XMA: 102221405(sirt3) 102222322(sirt1) 102222882(sirt7) 102226825(sirt5) 102227585 102234128(sirt4) 102237357 102238107(sirt6) 102238400(sirt2)
XCO: 114135312(sirt4) 114138276(sirt1) 114143546(sirt3) 114144477(sirt7) 114146803 114147170(sirt6) 114150751(sirt5) 114156786 114161611(sirt2)
PRET: 103463032(sirt3) 103463402(sirt5) 103464589(sirt4) 103465874(sirt7) 103466083 103474864(sirt2) 103477104(sirt1) 103479463 103479554
CVG: 107082761(sirt3) 107083000(sirt5) 107088648(sirt1) 107090740(sirt7) 107092410 107100054(sirt2) 107102585(sirt4) 107103190(sirt6) 107104162
NFU: 107373563(sirt2) 107375374(sirt1) 107382055(sirt3) 107383913 107384137(sirt6) 107385156(sirt4) 107388944 107392242(sirt7) 107393051(sirt5)
KMR: 108231140(sirt4) 108236305(sirt7) 108239417(sirt6) 108239590 108239958 108240687(sirt1) 108248348(sirt5) 108249846(sirt3) 108250375(sirt2)
ALIM: 106513124(sirt3) 106515597 106516083(sirt4) 106521455(sirt7) 106522134(sirt2) 106525621(sirt1) 106526375(sirt6) 106532264(sirt5) 106533933
AOCE: 111563232(sirt4) 111566026(sirt2) 111568703 111569881(sirt5) 111573092(sirt1) 111580344(sirt6) 111581956(sirt7) 111582551(sirt3) 111586640
CSEM: 103378255(sirt2) 103378865(sirt3) 103380163 103383954(sirt7) 103385765(sirt4) 103391355(sirt1) 103395932(sirt6) 103396282 103399853(sirt5)
POV: 109623890 109624168 109627220(sirt7) 109634091(sirt1) 109634618(sirt2) 109637691(sirt6) 109639223(sirt5) 109643380(sirt4) 109646116(sirt3) 109647853
LCF: 108875294 108875649(sirt7) 108879583(sirt5) 108883126(sirt2) 108883417 108883607(sirt6) 108886237(sirt1) 108889358(sirt4) 108894168(sirt3)
SDU: 111220735(sirt1) 111222803(sirt4) 111223343(sirt3) 111227531(sirt5) 111228405 111228887(sirt6) 111229259(sirt7) 111231072 111232857(sirt2)
SLAL: 111654251(sirt2) 111656651(sirt3) 111658893(sirt6) 111660745(sirt4) 111661044 111661779 111666696(sirt7) 111669537(sirt1) 111670468 111671795(sirt5)
BPEC: 110153590(sirt2) 110157658(sirt6) 110158058 110162160(sirt1) 110163823 110164021(sirt3) 110165217(sirt7) 110168603(sirt4) 110172275(sirt5)
MALB: 109952557(sirt2) 109957715 109958021(sirt7) 109961229(sirt1) 109961281(sirt5) 109966902 109969397(sirt6) 109971564(sirt3)
ELS: 105007371(sirt3) 105011946 105012033(sirt7) 105016891(sirt4) 105018639 105020481(sirt6) 105022153 105026873(sirt2) 105028637(sirt1)
SFM: 108921501(sirt6) 108928676(sirt2) 108930195(sirt7) 108932694(sirt1) 108935931 108937771 108938047(sirt4) 108939046 108942368(sirt3)
PKI: 111836562(sirt6) 111838705 111844087(sirt2) 111845831 111846584(sirt7) 111850102(sirt5) 111855069(sirt1) 111856552(sirt4) 111859490(sirt3)
LCM: 102346114(SIRT5) 102348704(SIRT1) 102353165(SIRT2) 102360444(SIRT4) 102361134(SIRT7) 102363985(SIRT3) 102364335 102364810(SIRT6)
CMK: 103171827(sirt2) 103171981(sirt5) 103175524(sirt7) 103179899 103181092(sirt1) 103183528(sirt6) 103188470(sirt4) 103190967(sirt3)
RTP: 109911768(sirt6) 109912079(sirt1) 109913423(sirt7) 109917225 109925697 109928127(sirt4) 109928812(sirt3) 109936753
DME: Dmel_CG11305(Sirt7) Dmel_CG3187(Sirt4) Dmel_CG5085(Sirt2) Dmel_CG5216(Sirt1) Dmel_CG6284(Sirt6)
DSI: Dsimw501_GD16246(Dsim_GD16246) Dsimw501_GD19348(Dsim_GD19348) Dsimw501_GD20725(Dsim_GD20725) Dsimw501_GD21410(Dsim_GD21410) Dsimw501_GD23867(Dsim_GD23867)
CEL: CELE_C06A5.11(sir-2.4) CELE_F46G10.3(sir-2.3) CELE_F46G10.7(sir-2.2) CELE_R11A8.4(sir-2.1)
CBR: CBG03922(Cbr-sir-2.4) CBG07776(Cbr-sir-2.2) CBG07777 CBG23756(Cbr-sir-2.1)
ATH: AT5G09230(SRT2) AT5G55760(SRT1)
LJA: Lj1g3v1356820.1(Lj1g3v1356820.1) Lj6g3v0738970.1(Lj6g3v0738970.1) Lj6g3v0738970.2(Lj6g3v0738970.2) Lj6g3v0738970.3(Lj6g3v0738970.3)
VVI: 100242368(SRT2) 100261752(SRT1)
DOSA: Os04t0271000-01(Os04g0271000) Os12t0179800-01(Os12g0179800)
ATS: 109752574(LOC109752574) 109759810(LOC109759810)
ZMA: 103642296 542568(cl3393_1)
APRO: F751_3582
SCE: YDL042C(SIR2) YDR191W(HST4) YOL068C(HST1) YOR025W(HST3) YPL015C(HST2)
KMX: KLMA_20212(HST2) KLMA_30182(SIR2) KLMA_50570(HST4)
NCS: NCAS_0B03050(NCAS0B03050) NCAS_0C03490(NCAS0C03490) NCAS_0G00840(NCAS0G00840) NCAS_0I02150(NCAS0I02150) NCAS_0J00610(NCAS0J00610)
NDI: NDAI_0A06750(NDAI0A06750) NDAI_0B05490(NDAI0B05490) NDAI_0C06280(NDAI0C06280) NDAI_0F00930(NDAI0F00930) NDAI_0G02830(NDAI0G02830)
TPF: TPHA_0A00880(TPHA0A00880) TPHA_0C00480(TPHA0C00480) TPHA_0L00930(TPHA0L00930) TPHA_0M00390(TPHA0M00390) TPHA_0P00380(TPHA0P00380)
TBL: TBLA_0D02680(TBLA0D02680) TBLA_0E03350(TBLA0E03350) TBLA_0F00920(TBLA0F00920) TBLA_0G03160(TBLA0G03160) TBLA_0H03210(TBLA0H03210) TBLA_0J00780(TBLA0J00780)
TDL: TDEL_0A04790(TDEL0A04790) TDEL_0C01020(TDEL0C01020) TDEL_0D04710(TDEL0D04710) TDEL_0F05200(TDEL0F05200)
KAF: KAFR_0B01640(KAFR0B01640) KAFR_0B06160(KAFR0B06160) KAFR_0C01100(KAFR0C01100) KAFR_0C05870(KAFR0C05870) KAFR_0F02130(KAFR0F02130)
PIC: PICST_2658(SIR2) PICST_32025(HST2) PICST_40594(SIR3) PICST_49645(HST3)
SLB: AWJ20_2281(HST2) AWJ20_4402(HST4) AWJ20_49(HST3) AWJ20_857(HST1)
NCR: NCU00523(nst-2) NCU03059(nst-3) NCU04737(nst-1) NCU07624(nst-7)
NTE: NEUTE1DRAFT72738(NEUTE1DRAFT_72738) NEUTE1DRAFT77995(NEUTE1DRAFT_77995) NEUTE1DRAFT88650(NEUTE1DRAFT_88650) NEUTE1DRAFT92837(NEUTE1DRAFT_92837)
ANG: ANI_1_1776074(An08g02500) ANI_1_3338024(An02g14390) ANI_1_988014(An01g07390)
SPO: SPAC1783.04c(hst4) SPBC16D10.07c(sir2) SPCC132.02(hst2)
ABP: AGABI1DRAFT110720(AGABI1DRAFT_110720) AGABI1DRAFT126352(AGABI1DRAFT_126352) AGABI1DRAFT41488(AGABI1DRAFT_41488) AGABI1DRAFT74670(AGABI1DRAFT_74670) AGABI1DRAFT79637(AGABI1DRAFT_79637)
ABV: AGABI2DRAFT187357(AGABI2DRAFT_187357) AGABI2DRAFT189378(AGABI2DRAFT_189378) AGABI2DRAFT206356(AGABI2DRAFT_206356) AGABI2DRAFT218192(AGABI2DRAFT_218192) AGABI2DRAFT224508(AGABI2DRAFT_224508)
MGL: MGL_0206
DDI: DDB_G0283917(sir2A) DDB_G0289967(sir2D)
DFA: DFA_07194(sir2C) DFA_08068(sir2D)
EHI: EHI_151300(2.t00031)
SMIN: v1.2.013706.t1(symbB.v1.2.013706.t1) v1.2.026788.t1(symbB.v1.2.026788.t1) v1.2.026788.t2(symbB.v1.2.026788.t2) v1.2.035092.t1(symbB.v1.2.035092.t1) v1.2.039854.t1(symbB.v1.2.039854.t1)
NGD: NGA_0390700(NPDA)
LMA: LMJF_26_0210(SIR2RP1)
LIF: LINJ_26_0200(SIR2RP1)
LBZ: LBRM_26_0210a(SIR2)
CCRO: CMC5_022870(cobB)
 » show all
Taxonomy
Reference
1  [PMID:11095969]
  Authors
Landry J, Slama JT, Sternglanz R
  Title
Role of NAD(+) in the deacetylase activity of the SIR2-like proteins.
  Journal
Biochem Biophys Res Commun 278:685-90 (2000)
Reference
2  [PMID:11747420]
  Authors
Sauve AA, Celic I, Avalos J, Deng H, Boeke JD, Schramm VL
  Title
Chemistry of gene silencing: the mechanism of NAD+-dependent deacetylation reactions.
  Journal
Biochemistry 40:15456-63 (2001)
Reference
3  [PMID:11336676]
  Authors
Min J, Landry J, Sternglanz R, Xu RM
  Title
Crystal structure of a SIR2 homolog-NAD complex.
  Journal
Cell 105:269-79 (2001)
  Sequence
[afu:AF_1676]
Reference
4  [PMID:14522996]
  Authors
Jackson MD, Schmidt MT, Oppenheimer NJ, Denu JM
  Title
Mechanism of nicotinamide inhibition and transglycosidation by Sir2 histone/protein deacetylases.
  Journal
J Biol Chem 278:50985-98 (2003)
Reference
5  [PMID:16756498]
  Authors
Sauve AA, Wolberger C, Schramm VL, Boeke JD
  Title
The biochemistry of sirtuins.
  Journal
Annu Rev Biochem 75:435-65 (2006)
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.286
IUBMB Enzyme Nomenclature: 2.3.1.286
ExPASy - ENZYME nomenclature database: 2.3.1.286
BRENDA, the Enzyme Database: 2.3.1.286
LinkDB All DBs

DBGET integrated database retrieval system