Transferases;
Acyltransferases;
Aminoacyltransferases
BRITE hierarchy

L-leucyl-tRNALeu:L-phenylalanyl-tRNAPhe leucyltransferase (cyclizing)

L-leucyl-tRNALeu + L-phenylalanyl-tRNAPhe = tRNALeu + tRNAPhe + cyclo(L-leucyl-L-phenylalanyl) [RN:R10334]

R10334
Reaction

L-leucyl-tRNA(Leu) [CPD:C02047];
L-phenylalanyl-tRNA(Phe) [CPD:C03511]

The reaction proceeds following a ping-pong mechanism forming a covalent intermediate between an active site serine and the L-phenylalanine residue [2]. The protein, found in the bacterium Streptomyces noursei, also forms cyclo(L-phenylalanyl-L-phenylalanyl), cyclo(L-methionyl-L-phenylalanyl), cyclo(L-phenylalanyl-L-tyrosyl) and cyclo(L-methionyl-L-tyrosyl) [1].

EC 2.3.2.20 created 2013

1  [PMID:19430487]

Gondry M, Sauguet L, Belin P, Thai R, Amouroux R, Tellier C, Tuphile K, Jacquet M, Braud S, Courcon M, Masson C, Dubois S, Lautru S, Lecoq A, Hashimoto S, Genet R, Pernodet JL

Cyclodipeptide synthases are a family of tRNA-dependent peptide bond-forming enzymes.

Nat Chem Biol 5:414-20 (2009)
DOI:10.1038/nchembio.175

[ag:AAN07909]

2  [PMID:21296757]

Sauguet L, Moutiez M, Li Y, Belin P, Seguin J, Le Du MH, Thai R, Masson C, Fonvielle M, Pernodet JL, Charbonnier JB, Gondry M

Cyclodipeptide synthases, a family of class-I aminoacyl-tRNA synthetase-like enzymes involved in non-ribosomal peptide synthesis.

Nucleic Acids Res 39:4475-89 (2011)
DOI:10.1093/nar/gkr027

[ag:AAN07909]