| Entry |
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| Name |
dolichyl-phosphate-mannose---protein mannosyltransferase;
dolichol phosphomannose-protein mannosyltransferase;
protein O-D-mannosyltransferase;
dolichyl-phosphate-D-mannose:protein O-D-mannosyltransferase;
dolichyl-phosphate-mannose-protein mannosyltransferase;
dolichyl-D-mannosyl-phosphate:protein O-D-mannosyltransferase
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| Class |
Transferases;
Glycosyltransferases;
Hexosyltransferases
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| Sysname |
dolichyl beta-D-mannosyl-phosphate:L-threonyl/L-seryl-[protein] O-D-mannosyltransferase (configuration-inverting)
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| Reaction(IUBMB) |
(1) dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = dolichyl phosphate + 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] [RN: R11399];
(2) dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = dolichyl phosphate + 3-O-(alpha-D-mannosyl)-L-seryl-[protein] [RN: R04072 R07620]
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| Reaction(KEGG) |
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| Substrate |
dolichyl beta-D-mannosyl phosphate [CPD: C03862];
L-threonyl-[protein];
L-seryl-[protein]
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| Product |
dolichyl phosphate [CPD: C00110];
3-O-(alpha-D-mannosyl)-L-threonyl-[protein] [CPD: C20722];
3-O-(alpha-D-mannosyl)-L-seryl-[protein]
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| Comment |
The enzyme transfers mannosyl residues to the hydroxy group of serine or threonine residues, producing cell-wall mannoproteins. It acts only on long-chain alpha-dihydropolyprenyl derivatives, larger than C35.
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| History |
EC 2.4.1.109 created 1983, modified 2014
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| Pathway |
| ec00514 | Other types of O-glycan biosynthesis |
| ec00515 | Mannose type O-glycan biosynthesis |
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| Orthology |
| K00728 | dolichyl-phosphate-mannose-protein mannosyltransferase |
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| Genes |
» show all
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| Reference |
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| Authors |
Babczinski P, Haselbeck A, Tanner W. |
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| Title |
Yeast mannosyl transferases requiring dolichyl phosphate and dolichyl phosphate mannose as substrate. Partial purification and characterization of the solubilized enzyme. |
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| Journal |
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| Reference |
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| Authors |
Palamarczyk G, Lehle L, Mankowski T, Chojnacki T, Tanner W. |
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| Title |
Specificity of solubilized yeast glycosyl transferases for polyprenyl derivatives. |
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| Journal |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.4.1.109 |
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| LinkDB |
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