ENZYME: 2.4.1.222
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Entry
EC 2.4.1.222 Enzyme
Name
O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase;
O-fucosylpeptide beta-1,3-N-acetylglucosaminyltransferase;
fringe (ambiguous)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-D-GlcNAc:O-L-fucosylpeptide 3-beta-N-acetyl-D-glucosaminyltransferase
Reaction(IUBMB)
transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor [RN:
R09296
]
Reaction(KEGG)
R09296
(G)
Reaction
Comment
O-Fucosylpeptide 3-beta-N-acetylglucosaminyltransferases are the products of fringe genes. O-linked fucose is an unusual form of glycosylation where the fucose is attached directly to proteins through the hydroxy groups of Ser or Thr residues.
History
EC 2.4.1.222 created 2002
Pathway
ec00514
Other types of O-glycan biosynthesis
Orthology
K05948
fringe
Genes
HSA:
3955
(LFNG)
4242
(MFNG)
5986
(RFNG)
PTR:
458811
(MFNG)
472272
(LFNG)
747153
(RFNG)
PPS:
100977920
(LFNG)
100980961
(RFNG)
100995551
(MFNG)
GGO:
101145692
(LFNG)
101150690
(RFNG)
PON:
100433262
(MFNG)
100453406
(RFNG)
100457821
(LFNG)
NLE:
100590152
(LFNG)
100599575
(MFNG)
100603704
(RFNG)
MCC:
100428736
(LFNG)
699530
(MFNG)
719330
(RFNG)
MCF:
101865860
102122259
(LFNG)
102132366
(MFNG)
CSAB:
103223279
(MFNG)
103243752
(RFNG)
103246864
(LFNG)
RRO:
104654981
(RFNG)
104664990
104682508
(MFNG)
RBB:
108512800
(MFNG)
108534090
(RFNG)
108543803
(LFNG)
CJC:
100394244
(RFNG)
100397083
(MFNG)
100397710
(LFNG)
SBQ:
101028632
(MFNG)
101031267
(RFNG)
101052656
(LFNG)
MMU:
16848
(Lfng)
17305
(Mfng)
19719
(Rfng)
MCAL:
110294717
(Lfng)
110304960
(Rfng)
110310660
(Mfng)
MPAH:
110312801
(Lfng)
110331255
(Rfng)
110334897
(Mfng)
RNO:
170905
(Lfng)
315119
(Mfng)
60433
(Rfng)
MUN:
110548858
(Rfng)
110554724
(Lfng)
110558853
(Mfng)
CGE:
100762397
(Lfng)
100762875
(Mfng)
100771257
(Rfng)
NGI:
103730070
(Rfng)
103748612
(Mfng)
103748675
(Lfng)
HGL:
101699763
(Lfng)
101722987
(Mfng)
101725480
(Rfng)
CCAN:
109683509
(Lfng)
109697229
(Mfng)
109702741
(Rfng)
OCU:
100355921
(LFNG)
100357457
(MFNG)
TUP:
102491172
(LFNG)
102493487
(RFNG)
102497808
(MFNG)
CFA:
483376
(RFNG)
489891
(LFNG)
610303
(MFNG)
VVP:
112920916
(RFNG)
112929107
(MFNG)
112929356
(LFNG)
AML:
100468722
(RFNG)
100470247
(MFNG)
100479208
(LFNG)
UMR:
103666011
(RFNG)
103670070
(LFNG)
103676401
(MFNG)
UAH:
113241808
(MFNG)
113244483
(RFNG)
113247705
(LFNG)
ORO:
101370080
(LFNG)
101373562
(RFNG)
101384739
(MFNG)
ELK:
111146201
111157518
111160292
FCA:
101080753
(RFNG)
101092320
(LFNG)
101097256
(MFNG)
PTG:
102956076
(RFNG)
102961069
(MFNG)
102962200
(LFNG)
PPAD:
109251132
(LFNG)
109265536
(MFNG)
109276754
(RFNG)
AJU:
106984500
(LFNG)
106986348
(RFNG)
113602730
(MFNG)
BTA:
505267
(MFNG)
516209
(LFNG)
532242
(RFNG)
BOM:
102276513
(MFNG)
102286691
(RFNG)
102288229
(LFNG)
BIU:
109559537
(MFNG)
109573332
(RFNG)
BBUB:
102394903
102410037
(LFNG)
102415597
(MFNG)
112584008
CHX:
102169449
(LFNG)
102178013
(RFNG)
102178708
(MFNG)
OAS:
101103554
(MFNG)
101106785
(RFNG)
101112372
(LFNG)
SSC:
100524978
(LFNG)
102161832
(MFNG)
110255925
(RFNG)
CFR:
102506111
(LFNG)
102509192
(RFNG)
102518312
(MFNG)
CDK:
105091974
(MFNG)
105102217
(RFNG)
105105769
(LFNG)
BACU:
103005287
(MFNG)
103009108
(LFNG)
103019781
(RFNG)
LVE:
103075553
(MFNG)
103076301
(RFNG)
103089921
(LFNG)
OOR:
101270479
(MFNG)
101278665
(RFNG)
101282067
(LFNG)
DLE:
111169357
(LFNG)
111182674
(RFNG)
111186217
(MFNG)
PCAD:
102977711
(RFNG)
102989837
(MFNG)
102990636
(LFNG)
ECB:
100057395
(RFNG)
100069766
(MFNG)
100147464
(LFNG)
EPZ:
103551123
(RFNG)
103566953
(LFNG)
103567118
(MFNG)
EAI:
106834776
(LFNG)
106837591
(MFNG)
106846141
(RFNG)
MYB:
102238965
(MFNG)
MYD:
102764930
(LFNG)
102767457
(MFNG)
MNA:
107537047
(LFNG)
107539057
(RFNG)
107545234
(MFNG)
HAI:
109380238
(LFNG)
109393064
(RFNG)
109394533
(MFNG)
DRO:
112298814
(RFNG)
112319527
(LFNG)
112321833
(MFNG)
PALE:
102879652
(RFNG)
102885010
(MFNG)
102892443
(LFNG)
RAY:
107519247
(MFNG)
107520206
(RFNG)
107521424
(LFNG)
MJV:
108392670
(MFNG)
108395246
(RFNG)
108398746
(LFNG)
LAV:
100655946
(LFNG)
100669607
(MFNG)
TMU:
101356202
MDO:
100012518
(LFNG)
100025532
(MFNG)
100029839
(RFNG)
SHR:
100914846
(MFNG)
100930580
(LFNG)
PCW:
110200103
(LFNG)
110205752
(MFNG)
110218311
(RFNG)
OAA:
100078922
(LFNG)
100088145
(RFNG)
100093244
(MFNG)
GGA:
395789
(RFNG)
395790
(LFNG)
418042
(MFNG)
MGP:
100539077
(MFNG)
100544514
(RFNG)
100549739
(LFNG)
CJO:
107313900
(MFNG)
107320761
(LFNG)
107322080
(RFNG)
NMEL:
110393122
(MFNG)
110405902
(LFNG)
APLA:
101790022
(MFNG)
101797427
(LFNG)
101800803
(RFNG)
ACYG:
106033576
(LFNG)
106035911
(MFNG)
106046760
(RFNG)
TGU:
100218383
(LFNG)
100232033
(MFNG)
100232663
(RFNG)
LSR:
110472408
(RFNG)
110475488
(LFNG)
110483830
(MFNG)
SCAN:
103813595
(MFNG)
103817861
(LFNG)
103819909
(RFNG)
GFR:
102032502
(MFNG)
102045456
(LFNG)
102045657
(RFNG)
FAB:
101808008
(MFNG)
101818865
(LFNG)
101819642
(RFNG)
PHI:
102103333
(RFNG)
102104211
(LFNG)
102107617
(MFNG)
PMAJ:
107205151
(MFNG)
107211349
(LFNG)
107212318
(RFNG)
CCAE:
111931257
111936281
(LFNG)
111937595
(RFNG)
CCW:
104685032
(LFNG)
104696299
(MFNG)
104698221
(RFNG)
ETL:
114055408
(MFNG)
114060198
(LFNG)
114060327
(RFNG)
FPG:
101914835
(RFNG)
101916406
(MFNG)
101916735
(LFNG)
FCH:
102047108
(LFNG)
102054672
(RFNG)
102059881
(MFNG)
CLV:
102084027
(LFNG)
102092690
(MFNG)
102094918
(RFNG)
EGZ:
104131255
(RFNG)
104132617
(LFNG)
104134305
(MFNG)
NNI:
104014390
(RFNG)
104015089
(LFNG)
104021594
(MFNG)
ACUN:
113485767
(LFNG)
113486842
(RFNG)
113491499
(MFNG)
PADL:
103913573
(LFNG)
103917468
(RFNG)
103924151
(MFNG)
AAM:
106487094
(RFNG)
106488480
(MFNG)
106496125
ASN:
102381094
(LFNG)
102386399
(RFNG)
102388348
(MFNG)
AMJ:
102566885
(LFNG)
102567014
(MFNG)
102571352
(RFNG)
PSS:
102443867
(LFNG)
102455692
102458358
(MFNG)
CMY:
102931854
102932974
(RFNG)
102935387
(MFNG)
CPIC:
101934811
(MFNG)
101940585
(RFNG)
101950276
(LFNG)
ACS:
100561637
(mfng)
100565009
(lfng)
100567901
(rfng)
PVT:
110075969
(MFNG)
110090776
(RFNG)
110091685
(LFNG)
PBI:
103060821
103063742
(RFNG)
PMUR:
107288860
(RFNG)
107290633
(LFNG)
TSR:
106551147
(RFNG)
PMUA:
114584152
(LFNG)
114589787
(RFNG)
114605544
(MFNG)
GJA:
107105918
(MFNG)
107118125
(RFNG)
107122012
(LFNG)
XLA:
100036937
(lfng.L)
394282
(rfng.L)
397855
(lfng.S)
397979
(xfringe2)
XTR:
100486895
(rfng)
549805
(lfng)
NPR:
108786198
(LFNG)
108791320
(RFNG)
DRE:
30158
(lfng)
414848
(rfng)
493633
(mfng)
SRX:
107708990
107715074
107753450
(lfng)
107757470
107758333
SANH:
107653613
107665528
107674646
107693671
(rfng)
107703400
SGH:
107561915
107562029
107581707
(lfng)
107600994
CCAR:
109046565
109047918
109063455
109083482
109099366
(rfng)
IPU:
108257411
(lfng)
108259517
108273644
(rfng)
PHYP:
113527078
(rfng)
113536168
(lfng)
AMEX:
103025168
(lfng)
103035856
(mfng)
103037421
(rfng)
EEE:
113571376
(lfng)
113574297
113589668
TRU:
101066309
101067911
(lfng)
101073166
101073848
TNG:
GSTEN00005496G001
GSTEN00006372G001
GSTEN00015727G001
GSTEN00034798G001
LCO:
104918731
(lfng)
104921160
104925295
104929533
(rfng)
NCC:
104940897
104964482
(lfng)
MZE:
101466218
(rfng)
101467699
101469344
101485425
ONL:
100696743
(rfng)
100697735
100707701
100708834
OLA:
101155324
101156689
(rfng)
101169038
(lfng)
101174979
XMA:
102219280
(rfng)
102225648
102230356
(lfng)
XCO:
114145337
114150882
(rfng)
114160037
(lfng)
PRET:
103468664
(lfng)
103480636
103482187
(rfng)
CVG:
107084259
107084747
(lfng)
107087619
(rfng)
107099338
NFU:
107372602
107378430
(lfng)
107389966
107391332
KMR:
108237295
(mfng)
108245159
(rfng)
108245271
108246120
(lfng)
ALIM:
106522721
(lfng)
106527238
106532938
106537334
AOCE:
111565184
(rfng)
111566263
111569841
111581680
CSEM:
103381663
(rfng)
103383433
103383472
103392616
POV:
109627033
109639604
(lfng)
109640166
109646450
LCF:
108876800
(rfng)
108880842
108894766
108900781
(lfng)
SDU:
111216706
111217747
(lfng)
111235903
111237097
(rfng)
SLAL:
111657941
111660595
(lfng)
111664402
(rfng)
111672994
HCQ:
109511290
109511291
109513832
(lfng)
109529290
BPEC:
110154327
(rfng)
110165650
110167656
(lfng)
MALB:
109964190
(lfng)
109966694
(rfng)
109970347
109973279
SASA:
106589611
(rfng)
106593718
106594217
106601125
106607332
106610281
OTW:
112224491
(rfng)
112226024
112240162
112240408
112240410
112259205
SALP:
111980694
111981123
112070915
112080424
(rfng)
ELS:
105005737
105013213
(lfng)
109614596
109614605
(rfng)
SFM:
108922521
108926351
108927511
108939756
(rfng)
PKI:
111832910
111845285
(mfng)
111845492
111853276
LCM:
102347945
(LFNG)
102350505
(MFNG)
102362901
(RFNG)
CMK:
103175474
(rfng)
103186827
(lfng)
103189782
RTP:
109914750
109917090
109925965
109930933
(rfng)
BFO:
118428905
CIN:
113474334
778622
778624
778625
778626
SPU:
578181
APLC:
110981883
110989661
SKO:
100653401
(fng)
DME:
Dmel_CG10580
(fng)
DER:
6546161
DSE:
6616375
DSI:
Dsimw501_GD28062
(Dsim_GD28062)
DYA:
Dyak_GE22371
Dyak_GE28150
DAN:
6493073
DSR:
110189997
DPO:
Dpse_GA10411
DPE:
6604426
DMN:
108153338
DGR:
Dgri_GH15563
DMO:
Dmoj_GI16838
DAZ:
108614550
DNV:
108650377
DHE:
111592962
DVI:
6624162
MDE:
101890371
LCQ:
111676980
AGA:
AgaP_AGAP006439
AAG:
5574115
AALB:
109623129
CQU:
CpipJ_CPIJ010821
CpipJ_CPIJ010824
AME:
551501
BIM:
100741335
BTER:
100648290
CCAL:
108624015
OBB:
114878915
SOC:
105201656
MPHA:
105832301
AEC:
105145067
ACEP:
105624750
PBAR:
105422509
VEM:
105562750
HST:
105185424
DQU:
106741484
CFO:
105251037
LHU:
105675165
PGC:
109851939
OBO:
105276314
PCF:
106790982
NVI:
100678242
CSOL:
105361405
MDL:
103571993
106693367
TCA:
100141773
DPA:
109540120
ATD:
109598146
NVL:
108560087
108566740
BMOR:
100144549
(Fng)
BMAN:
114243226
DPL:
KGM_202101
PMAC:
106718445
PRAP:
110995650
HAW:
110371554
TNL:
113504560
PXY:
105390350
105390361
API:
100160830
DNX:
107164992
AGS:
114126629
RMD:
113553865
BTAB:
109037881
CLEC:
106661495
PHU:
Phum_PHUM014770
ZNE:
110830882
FCD:
110847136
DPX:
DAPPUDRAFT_93561
PVM:
113813153
ISC:
IscW_ISCW009494
TUT:
107360014
DPTE:
113793628
CSCU:
111617733
111619390
PTEP:
107441830
LGI:
LOTGIDRAFT_93476
PCAN:
112561686
CRG:
105321777
MYI:
110453003
OBI:
106871323
LAK:
106168328
NVE:
116603670
EPA:
110237675
ADF:
107346687
AMIL:
114964698
PDAM:
113678576
SPIS:
111340325
AQU:
100632073
100632325
100637378
100637506
100637631
105314240
105314592
TVA:
TVAG_276250
» show all
Taxonomy
Reference
1 [PMID:
10935626
]
Authors
Moloney DJ, Panin VM, Johnston SH, Chen J, Shao L, Wilson R, Wang Y, Stanley P, Irvine KD, Haltiwanger RS, Vogt TF.
Title
Fringe is a glycosyltransferase that modifies Notch.
Journal
Nature 406:369-75 (2000)
DOI:
10.1038/35019000
Sequence
[dme:
Dmel_CG10580
] [hsa:
4242
]
Other DBs
ExplorEnz - The Enzyme Database:
2.4.1.222
IUBMB Enzyme Nomenclature:
2.4.1.222
ExPASy - ENZYME nomenclature database:
2.4.1.222
BRENDA, the Enzyme Database:
2.4.1.222
CAS:
299203-70-6
LinkDB
All DBs
DBGET
integrated database retrieval system