KEGG   ENZYME: 2.4.1.222
Entry
EC 2.4.1.222                Enzyme                                 

Name
O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase;
O-fucosylpeptide beta-1,3-N-acetylglucosaminyltransferase;
fringe (ambiguous)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-D-GlcNAc:O-L-fucosylpeptide 3-beta-N-acetyl-D-glucosaminyltransferase
Reaction(IUBMB)
transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor [RN:R09296]
Reaction(KEGG)
R09296(G)
Comment
O-Fucosylpeptide 3-beta-N-acetylglucosaminyltransferases are the products of fringe genes. O-linked fucose is an unusual form of glycosylation where the fucose is attached directly to proteins through the hydroxy groups of Ser or Thr residues.
History
EC 2.4.1.222 created 2002
Pathway
ec00514  Other types of O-glycan biosynthesis
Orthology
K05948  fringe
Genes
HSA: 3955(LFNG) 4242(MFNG) 5986(RFNG)
PTR: 458811(MFNG) 472272(LFNG) 747153(RFNG)
PPS: 100977920(LFNG) 100980961(RFNG) 100995551(MFNG)
GGO: 101145692(LFNG) 101150690(RFNG)
PON: 100433262(MFNG) 100453406(RFNG) 100457821(LFNG)
NLE: 100590152(LFNG) 100599575(MFNG) 100603704(RFNG)
MCC: 100428736(LFNG) 699530(MFNG) 719330(RFNG)
MCF: 101865860 102122259(LFNG) 102132366(MFNG)
CSAB: 103223279(MFNG) 103243752(RFNG) 103246864(LFNG)
RRO: 104654981(RFNG) 104664990 104682508(MFNG)
RBB: 108512800(MFNG) 108534090(RFNG) 108543803(LFNG)
CJC: 100394244(RFNG) 100397083(MFNG) 100397710(LFNG)
SBQ: 101028632(MFNG) 101031267(RFNG) 101052656(LFNG)
MMU: 16848(Lfng) 17305(Mfng) 19719(Rfng)
MCAL: 110294717(Lfng) 110304960(Rfng) 110310660(Mfng)
MPAH: 110312801(Lfng) 110331255(Rfng) 110334897(Mfng)
RNO: 170905(Lfng) 315119(Mfng) 60433(Rfng)
MUN: 110548858(Rfng) 110554724(Lfng) 110558853(Mfng)
CGE: 100762397(Lfng) 100762875(Mfng) 100771257(Rfng)
NGI: 103730070(Rfng) 103748612(Mfng) 103748675(Lfng)
HGL: 101699763(Lfng) 101722987(Mfng) 101725480(Rfng)
CCAN: 109683509(Lfng) 109697229(Mfng) 109702741(Rfng)
OCU: 100355921(LFNG) 100357457(MFNG)
TUP: 102491172(LFNG) 102493487(RFNG) 102497808(MFNG)
CFA: 483376(RFNG) 489891(LFNG) 610303(MFNG)
VVP: 112920916(RFNG) 112929107(MFNG) 112929356(LFNG)
AML: 100468722(RFNG) 100470247(MFNG) 100479208(LFNG)
UMR: 103666011(RFNG) 103670070(LFNG) 103676401(MFNG)
UAH: 113241808(MFNG) 113244483(RFNG) 113247705(LFNG)
ORO: 101370080(LFNG) 101373562(RFNG) 101384739(MFNG)
ELK: 111146201 111157518 111160292
FCA: 101080753(RFNG) 101092320(LFNG) 101097256(MFNG)
PTG: 102956076(RFNG) 102961069(MFNG) 102962200(LFNG)
PPAD: 109251132(LFNG) 109265536(MFNG) 109276754(RFNG)
AJU: 106984500(LFNG) 106986348(RFNG) 113602730(MFNG)
BTA: 505267(MFNG) 516209(LFNG) 532242(RFNG)
BOM: 102276513(MFNG) 102286691(RFNG) 102288229(LFNG)
BIU: 109559537(MFNG) 109573332(RFNG)
BBUB: 102394903 102410037(LFNG) 102415597(MFNG) 112584008
CHX: 102169449(LFNG) 102178013(RFNG) 102178708(MFNG)
OAS: 101103554(MFNG) 101106785(RFNG) 101112372(LFNG)
SSC: 100524978(LFNG) 102161832(MFNG) 110255925(RFNG)
CFR: 102506111(LFNG) 102509192(RFNG) 102518312(MFNG)
CDK: 105091974(MFNG) 105102217(RFNG) 105105769(LFNG)
BACU: 103005287(MFNG) 103009108(LFNG) 103019781(RFNG)
LVE: 103075553(MFNG) 103076301(RFNG) 103089921(LFNG)
OOR: 101270479(MFNG) 101278665(RFNG) 101282067(LFNG)
DLE: 111169357(LFNG) 111182674(RFNG) 111186217(MFNG)
PCAD: 102977711(RFNG) 102989837(MFNG) 102990636(LFNG)
ECB: 100057395(RFNG) 100069766(MFNG) 100147464(LFNG)
EPZ: 103551123(RFNG) 103566953(LFNG) 103567118(MFNG)
EAI: 106834776(LFNG) 106837591(MFNG) 106846141(RFNG)
MYB: 102238965(MFNG)
MYD: 102764930(LFNG) 102767457(MFNG)
MNA: 107537047(LFNG) 107539057(RFNG) 107545234(MFNG)
HAI: 109380238(LFNG) 109393064(RFNG) 109394533(MFNG)
DRO: 112298814(RFNG) 112319527(LFNG) 112321833(MFNG)
PALE: 102879652(RFNG) 102885010(MFNG) 102892443(LFNG)
RAY: 107519247(MFNG) 107520206(RFNG) 107521424(LFNG)
MJV: 108392670(MFNG) 108395246(RFNG) 108398746(LFNG)
LAV: 100655946(LFNG) 100669607(MFNG)
TMU: 101356202
MDO: 100012518(LFNG) 100025532(MFNG) 100029839(RFNG)
SHR: 100914846(MFNG) 100930580(LFNG)
PCW: 110200103(LFNG) 110205752(MFNG) 110218311(RFNG)
OAA: 100078922(LFNG) 100088145(RFNG) 100093244(MFNG)
GGA: 395789(RFNG) 395790(LFNG) 418042(MFNG)
MGP: 100539077(MFNG) 100544514(RFNG) 100549739(LFNG)
CJO: 107313900(MFNG) 107320761(LFNG) 107322080(RFNG)
NMEL: 110393122(MFNG) 110405902(LFNG)
APLA: 101790022(MFNG) 101797427(LFNG) 101800803(RFNG)
ACYG: 106033576(LFNG) 106035911(MFNG) 106046760(RFNG)
TGU: 100218383(LFNG) 100232033(MFNG) 100232663(RFNG)
LSR: 110472408(RFNG) 110475488(LFNG) 110483830(MFNG)
SCAN: 103813595(MFNG) 103817861(LFNG) 103819909(RFNG)
GFR: 102032502(MFNG) 102045456(LFNG) 102045657(RFNG)
FAB: 101808008(MFNG) 101818865(LFNG) 101819642(RFNG)
PHI: 102103333(RFNG) 102104211(LFNG) 102107617(MFNG)
PMAJ: 107205151(MFNG) 107211349(LFNG) 107212318(RFNG)
CCAE: 111931257 111936281(LFNG) 111937595(RFNG)
CCW: 104685032(LFNG) 104696299(MFNG) 104698221(RFNG)
ETL: 114055408(MFNG) 114060198(LFNG) 114060327(RFNG)
FPG: 101914835(RFNG) 101916406(MFNG) 101916735(LFNG)
FCH: 102047108(LFNG) 102054672(RFNG) 102059881(MFNG)
CLV: 102084027(LFNG) 102092690(MFNG) 102094918(RFNG)
EGZ: 104131255(RFNG) 104132617(LFNG) 104134305(MFNG)
NNI: 104014390(RFNG) 104015089(LFNG) 104021594(MFNG)
ACUN: 113485767(LFNG) 113486842(RFNG) 113491499(MFNG)
PADL: 103913573(LFNG) 103917468(RFNG) 103924151(MFNG)
AAM: 106487094(RFNG) 106488480(MFNG) 106496125
ASN: 102381094(LFNG) 102386399(RFNG) 102388348(MFNG)
AMJ: 102566885(LFNG) 102567014(MFNG) 102571352(RFNG)
PSS: 102443867(LFNG) 102455692 102458358(MFNG)
CMY: 102931854 102932974(RFNG) 102935387(MFNG)
CPIC: 101934811(MFNG) 101940585(RFNG) 101950276(LFNG)
ACS: 100561637(mfng) 100565009(lfng) 100567901(rfng)
PVT: 110075969(MFNG) 110090776(RFNG) 110091685(LFNG)
PBI: 103060821 103063742(RFNG)
PMUR: 107288860(RFNG) 107290633(LFNG)
TSR: 106551147(RFNG)
PMUA: 114584152(LFNG) 114589787(RFNG) 114605544(MFNG)
GJA: 107105918(MFNG) 107118125(RFNG) 107122012(LFNG)
XLA: 100036937(lfng.L) 394282(rfng.L) 397855(lfng.S) 397979(xfringe2)
XTR: 100486895(rfng) 549805(lfng)
NPR: 108786198(LFNG) 108791320(RFNG)
DRE: 30158(lfng) 414848(rfng) 493633(mfng)
SRX: 107708990 107715074 107753450(lfng) 107757470 107758333
SANH: 107653613 107665528 107674646 107693671(rfng) 107703400
SGH: 107561915 107562029 107581707(lfng) 107600994
CCAR: 109046565 109047918 109063455 109083482 109099366(rfng)
IPU: 108257411(lfng) 108259517 108273644(rfng)
PHYP: 113527078(rfng) 113536168(lfng)
AMEX: 103025168(lfng) 103035856(mfng) 103037421(rfng)
EEE: 113571376(lfng) 113574297 113589668
TRU: 101066309 101067911(lfng) 101073166 101073848
TNG: GSTEN00005496G001 GSTEN00006372G001 GSTEN00015727G001 GSTEN00034798G001
LCO: 104918731(lfng) 104921160 104925295 104929533(rfng)
NCC: 104940897 104964482(lfng)
MZE: 101466218(rfng) 101467699 101469344 101485425
ONL: 100696743(rfng) 100697735 100707701 100708834
OLA: 101155324 101156689(rfng) 101169038(lfng) 101174979
XMA: 102219280(rfng) 102225648 102230356(lfng)
XCO: 114145337 114150882(rfng) 114160037(lfng)
PRET: 103468664(lfng) 103480636 103482187(rfng)
CVG: 107084259 107084747(lfng) 107087619(rfng) 107099338
NFU: 107372602 107378430(lfng) 107389966 107391332
KMR: 108237295(mfng) 108245159(rfng) 108245271 108246120(lfng)
ALIM: 106522721(lfng) 106527238 106532938 106537334
AOCE: 111565184(rfng) 111566263 111569841 111581680
CSEM: 103381663(rfng) 103383433 103383472 103392616
POV: 109627033 109639604(lfng) 109640166 109646450
LCF: 108876800(rfng) 108880842 108894766 108900781(lfng)
SDU: 111216706 111217747(lfng) 111235903 111237097(rfng)
SLAL: 111657941 111660595(lfng) 111664402(rfng) 111672994
HCQ: 109511290 109511291 109513832(lfng) 109529290
BPEC: 110154327(rfng) 110165650 110167656(lfng)
MALB: 109964190(lfng) 109966694(rfng) 109970347 109973279
SASA: 106589611(rfng) 106593718 106594217 106601125 106607332 106610281
OTW: 112224491(rfng) 112226024 112240162 112240408 112240410 112259205
SALP: 111980694 111981123 112070915 112080424(rfng)
ELS: 105005737 105013213(lfng) 109614596 109614605(rfng)
SFM: 108922521 108926351 108927511 108939756(rfng)
PKI: 111832910 111845285(mfng) 111845492 111853276
LCM: 102347945(LFNG) 102350505(MFNG) 102362901(RFNG)
CMK: 103175474(rfng) 103186827(lfng) 103189782
RTP: 109914750 109917090 109925965 109930933(rfng)
BFO: 118428905
CIN: 113474334 778622 778624 778625 778626
SPU: 578181
APLC: 110981883 110989661
SKO: 100653401(fng)
DME: Dmel_CG10580(fng)
DER: 6546161
DSE: 6616375
DSI: Dsimw501_GD28062(Dsim_GD28062)
DYA: Dyak_GE22371 Dyak_GE28150
DAN: 6493073
DSR: 110189997
DPO: Dpse_GA10411
DPE: 6604426
DMN: 108153338
DGR: Dgri_GH15563
DMO: Dmoj_GI16838
DAZ: 108614550
DNV: 108650377
DHE: 111592962
DVI: 6624162
MDE: 101890371
LCQ: 111676980
AGA: AgaP_AGAP006439
AAG: 5574115
AALB: 109623129
CQU: CpipJ_CPIJ010821 CpipJ_CPIJ010824
AME: 551501
BIM: 100741335
BTER: 100648290
CCAL: 108624015
OBB: 114878915
SOC: 105201656
MPHA: 105832301
AEC: 105145067
ACEP: 105624750
PBAR: 105422509
VEM: 105562750
HST: 105185424
DQU: 106741484
CFO: 105251037
LHU: 105675165
PGC: 109851939
OBO: 105276314
PCF: 106790982
NVI: 100678242
CSOL: 105361405
MDL: 103571993 106693367
TCA: 100141773
DPA: 109540120
ATD: 109598146
NVL: 108560087 108566740
BMOR: 100144549(Fng)
BMAN: 114243226
DPL: KGM_202101
PMAC: 106718445
PRAP: 110995650
HAW: 110371554
TNL: 113504560
PXY: 105390350 105390361
API: 100160830
DNX: 107164992
AGS: 114126629
RMD: 113553865
BTAB: 109037881
CLEC: 106661495
PHU: Phum_PHUM014770
ZNE: 110830882
FCD: 110847136
DPX: DAPPUDRAFT_93561
PVM: 113813153
ISC: IscW_ISCW009494
TUT: 107360014
DPTE: 113793628
CSCU: 111617733 111619390
PTEP: 107441830
LGI: LOTGIDRAFT_93476
PCAN: 112561686
CRG: 105321777
MYI: 110453003
OBI: 106871323
LAK: 106168328
NVE: 116603670
EPA: 110237675
ADF: 107346687
AMIL: 114964698
PDAM: 113678576
SPIS: 111340325
AQU: 100632073 100632325 100637378 100637506 100637631 105314240 105314592
TVA: TVAG_276250
 » show all
Reference
1  [PMID:10935626]
  Authors
Moloney DJ, Panin VM, Johnston SH, Chen J, Shao L, Wilson R, Wang Y, Stanley P, Irvine KD, Haltiwanger RS, Vogt TF.
  Title
Fringe is a glycosyltransferase that modifies Notch.
  Journal
Nature 406:369-75 (2000)
DOI:10.1038/35019000
  Sequence
[dme:Dmel_CG10580] [hsa:4242]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.222
IUBMB Enzyme Nomenclature: 2.4.1.222
ExPASy - ENZYME nomenclature database: 2.4.1.222
BRENDA, the Enzyme Database: 2.4.1.222
CAS: 299203-70-6
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