KEGG   ENZYME: 2.4.1.302
Entry
EC 2.4.1.302                Enzyme                                 

Name
L-demethylnoviosyl transferase;
novM (gene name);
dTDP-beta-L-noviose:novobiocic acid 7-O-noviosyltransferase;
L-noviosyl transferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
dTDP-4-O-demethyl-beta-L-noviose:novobiocic acid 7-O-[4-O-demethyl-L-noviosyl]transferase
Reaction(IUBMB)
dTDP-4-O-demethyl-beta-L-noviose + novobiocic acid = dTDP + demethyldecarbamoyl novobiocin [RN:R06770]
Reaction(KEGG)
R06770
Substrate
dTDP-4-O-demethyl-beta-L-noviose [CPD:C12481];
novobiocic acid [CPD:C12474]
Product
dTDP [CPD:C00363];
demethyldecarbamoyl novobiocin
Comment
The enzyme is involved in the biosynthesis of the aminocoumarin antibiotic, novobiocin.
History
EC 2.4.1.302 created 2013, modified 2016
Pathway
ec00401  Novobiocin biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K12711  L-demethylnoviosyl transferase
Genes
NGV: CDO52_02205
Reference
1  [PMID:12680772]
  Authors
Freel Meyers CL, Oberthur M, Anderson JW, Kahne D, Walsh CT
  Title
Initial characterization of novobiocic acid noviosyl transferase activity of NovM in biosynthesis of the antibiotic novobiocin.
  Journal
Biochemistry 42:4179-89 (2003)
DOI:10.1021/bi0340088
  Sequence
Reference
2  [PMID:12633109]
  Authors
Albermann C, Soriano A, Jiang J, Vollmer H, Biggins JB, Barton WA, Lesniak J, Nikolov DB, Thorson JS
  Title
Substrate specificity of NovM: implications for novobiocin biosynthesis and glycorandomization.
  Journal
Org Lett 5:933-6 (2003)
DOI:10.1021/ol0341086
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.302
IUBMB Enzyme Nomenclature: 2.4.1.302
ExPASy - ENZYME nomenclature database: 2.4.1.302
BRENDA, the Enzyme Database: 2.4.1.302
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