KEGG   ENZYME: 2.4.1.348Help
Entry
EC 2.4.1.348                Enzyme                                 

Name
N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 3-alpha-mannosyltransferase;
WbdC
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
GDP-alpha-D-mannose:N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 3-alpha-mannosyltransferase (configuration-retaining)
Reaction(IUBMB)
GDP-alpha-D-mannose + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = GDP + alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [RN:R11937]
Reaction(KEGG)
Substrate
GDP-alpha-D-mannose [CPD:C00096];
N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C01289]
Product
GDP [CPD:C00035];
alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C21780]
Comment
The enzyme is involved in the biosynthesis of the linker region of the polymannose O-polysaccharide in the outer leaflet of the membrane of Escherichia coli serotypes O8, O9 and O9a.
History
EC 2.4.1.348 created 2017
Orthology
K12995  N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 3-alpha-mannosyltransferase / rhamnosyltransferase
Genes
ELH: ETEC_2183
ECX: EcHS_A2166
ECR: ECIAI1_2097(wbdC)
ECOA: APECO78_13930
SBG: SBG_0618(wbdC)
SBZ: A464_691
SBV: N643_03115
ENT: Ent638_2645
ECLS: LI67_011350
ENX: NI40_014525
KPE: KPK_1682
KPJ: N559_1774
KVA: Kvar_1572
AHN: NCTC12129_03343(pimA)
PSTS: E05_49630
YET: CH48_3105
YAL: AT01_3986
YIN: CH53_3322
YRO: CH64_57
SPLY: Q5A_007995(pimA)
SMW: SMWW4_v1c15900(wbpZ)
SMAC: SMDB11_0878(wbcW)
SERF: L085_20530
SGL: SG1121
SOD: Sant_1473(wbcW)
DDQ: DDI_3694
PAM: PANA_2482
XAC: XAC0042(wbpZ)
XCI: XCAW_00427(wbpZ)
VCH: VC0259
VCS: MS6_0123
VCE: Vch1786_I2541(rfbV)
VCI: O3Y_01205
VCO: VC0395_A2637(rfbV)
VCR: VC395_0288(rfbV)
VCM: VCM66_0244(rfbV)
PAE: PA5447(wbpZ)
PAEV: N297_5635
PAEI: N296_5635
PAU: PA14_71910(wbpZ)
PAP: PSPA7_6237(wbpZ)
PAG: PLES_58421(wbpZ)
PAF: PAM18_5569(wbpZ)
PNC: NCGM2_6224(wbpZ)
PAEB: NCGM1900_6302(wbpZ)
PAEP: PA1S_29425
PAEM: U769_29930
PAEL: T223_29890
PAEU: BN889_06054(wbpZ)
PAEG: AI22_04560
PAEC: M802_5633
PAEO: M801_5500
PPU: PP_1802(wbpZ)
PPT: PPS_1444
PPI: YSA_02161
PPX: T1E_3061
PPUT: L483_06565
PPUD: DW66_1724
PMON: X969_05150
PMOT: X970_05125
PSB: Psyr_0914
PPRO: PPC_1982(RfaG)
PFO: Pfl01_5688(wbpZ)
PFE: PSF113_5892(wbpZ)
PMAN: OU5_3471
PKC: PKB_5496
PSES: PSCI_5264
PSEM: TO66_31530
PSPO: PSPO_a0447(wbpZ)
MICC: AUP74_02367(kanE_1)
TMC: LMI_2121
FTU: FTT_0792
FTQ: RO31_0910
FTF: FTF0792
FTW: FTW_0589
FTT: FTV_0748
FTG: FTU_0832
FTL: FTL_1429
FTH: FTH_1392(waaG)
FTA: FTA_1517
FTS: F92_07965
FTI: FTS_1403(waaG)
FTC: DA46_1321
FTV: CH67_1827
FTZ: CH68_1557
FTM: FTM_1046
FTN: FTN_1218
FTX: AW25_789
FTD: AS84_1293
FTY: CH70_707
FPM: LA56_687
FPJ: LA02_1152
FNA: OOM_1610
MEJ: Q7A_1109
MEC: Q7C_2293
NOC: Noc_1236
NHL: Nhal_2601
NWA: Nwat_1124
NTT: TAO_0815
AHA: AHA_2894
REH: H16_A2897(h16_A2897)
CTI: RALTA_B1932(wbpZ)
CGD: CR3_0509(wbpZ)
BCEW: DM40_1541
BCEO: I35_0740
BCED: DM42_946
BTEI: WS51_14690
BSTG: WT74_04285
AMIM: MIM_c06870
HRB: Hrubri_0467(wbpZ)
CFU: CFU_1123(wbpZ)
CARE: LT85_3687
MFA: Mfla_1275
AZO: azo3584
AOA: dqs_3727
HMS: HMU06650
DGG: DGI_1461
DTO: TOL2_C14040(wbpZ)
MXA: MXAN_1026
ARA: Arad_4816
BME: BMEI1393
BMEL: DK63_10
BMEE: DK62_864
BMF: BAB1_0563
BABO: DK55_568
BABR: DO74_1320
BABT: DK49_330
BABB: DK48_1549
BABU: DK53_557
BABS: DK51_903
BABC: DO78_475
BMS: BR0540
BSZ: DK67_1465
BCAR: DK60_619
BCAS: DA85_02565
BMR: BMI_I539
BPP: BPI_I573
BPV: DK65_820
RPC: RPC_4206
SPSE: SULPSESMR1_04937(pimA)
SPHT: K426_25930
RCH: RUM_03130
FPA: FPR_28570
RCA: Rcas_1839
CAG: Cagg_2638
BOA: Bovatus_04913(pimB)
FLN: FLA_6266
SMIZ: 4412673_02346(mshA_2)
EAO: BD94_3307
ELB: VO54_03317(kanE_1)
MARN: LN42_06685
NAT: NJ7G_1494
 » show all
Taxonomy
Reference
1  [PMID:22875852]
  Authors
Greenfield LK, Richards MR, Li J, Wakarchuk WW, Lowary TL, Whitfield C
  Title
Biosynthesis of the polymannose lipopolysaccharide O-antigens from Escherichia coli serotypes O8 and O9a requires a unique combination of single- and multiple-active site mannosyltransferases.
  Journal
J Biol Chem 287:35078-91 (2012)
DOI:10.1074/jbc.M112.401000
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.348
IUBMB Enzyme Nomenclature: 2.4.1.348
ExPASy - ENZYME nomenclature database: 2.4.1.348
BRENDA, the Enzyme Database: 2.4.1.348
LinkDB All DBs

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