KEGG   ENZYME: 2.4.1.366
Entry
EC 2.4.1.366                Enzyme                                 
Name
ginsenoside F1 6-O-glucosyltransferase;
UGTPg101 (gene name)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-alpha-D-glucose:ginsenoside F1 6-O-glucosyltransferase
Reaction(IUBMB)
UDP-alpha-D-glucose + ginsenoside F1 = UDP + (20S)-ginsenoside Rg1 [RN:R12387]
Reaction(KEGG)
R12387
Substrate
UDP-alpha-D-glucose [CPD:C00029];
ginsenoside F1 [CPD:C20780]
Product
UDP [CPD:C00015];
(20S)-ginsenoside Rg1 [CPD:C08946]
Comment
The enzyme, characterized from the plant Panax ginseng, glucosylates the C-6 position of ginsenoside F1. The enzyme also glucosylates the C-20 position of protopanaxatriol, which forms ginsenoside F1 (cf. EC 2.4.1.363, ginsenoside 20-O-glucosyltransferase). However, unlike EC 2.4.1.367, ginsenoside 6-O-glucosyltransferase, it is not able to glucosylate the C-6 position of protopanaxatriol when position C-20 is not glucosylated.
History
EC 2.4.1.366 created 2019
Orthology
K23523  ginsenoside F1 6-O-glucosyltransferase
Reference
1  [PMID:26032089]
  Authors
Wei W, Wang P, Wei Y, Liu Q, Yang C, Zhao G, Yue J, Yan X, Zhou Z
  Title
Characterization of Panax ginseng UDP-Glycosyltransferases Catalyzing Protopanaxatriol and Biosyntheses of Bioactive Ginsenosides F1 and Rh1 in Metabolically Engineered Yeasts.
  Journal
Mol Plant 8:1412-24 (2015)
DOI:10.1016/j.molp.2015.05.010
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.366
IUBMB Enzyme Nomenclature: 2.4.1.366
ExPASy - ENZYME nomenclature database: 2.4.1.366
BRENDA, the Enzyme Database: 2.4.1.366
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