Entry |
|
Name |
thymidine phosphorylase;
pyrimidine phosphorylase;
thymidine-orthophosphate deoxyribosyltransferase;
animal growth regulators, blood platelet-derived endothelial cell growth factors;
blood platelet-derived endothelial cell growth factor;
deoxythymidine phosphorylase;
gliostatins;
pyrimidine deoxynucleoside phosphorylase;
thymidine:phosphate deoxy-D-ribosyltransferase
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Class |
Transferases;
Glycosyltransferases;
Pentosyltransferases
|
Sysname |
thymidine:phosphate deoxy-alpha-D-ribosyltransferase
|
Reaction(IUBMB) |
thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate [RN: R01570]
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Reaction(KEGG) |
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Substrate |
|
Product |
thymine [CPD: C00178];
2-deoxy-alpha-D-ribose 1-phosphate [CPD: C00672]
|
Comment |
The enzyme in some tissues also catalyses deoxyribosyltransferase reactions of the type catalysed by EC 2.4.2.6, nucleoside deoxyribosyltransferase.
|
History |
EC 2.4.2.4 created 1961
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Pathway |
ec00983 | Drug metabolism - other enzymes |
|
Orthology |
K00758 | thymidine phosphorylase |
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Genes |
» show all
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Reference |
|
Authors |
FRIEDKIN M, ROBERTS D. |
Title |
The enzymatic synthesis of nucleosides. I. Thymidine phosphorylase in mammalian tissue. |
Journal |
J Biol Chem 207:245-56 (1954) |
Reference |
|
Authors |
ZIMMERMAN M, SEIDENBERG J. |
Title |
DEOXYRIBOSYL TRANSFER. I. THYMIDINE PHOSPHORYLASE AND NUCLEOSIDE DEOXYRIBOSYLTRANSFERASE IN NORMAL AND MALIGNANT TISSUES. |
Journal |
J Biol Chem 239:2618-21 (1964) |
Reference |
|
Authors |
ZIMMERMAN M. |
Title |
DEOXYRIBOSYL TRANSFER. II. NUCLEOSIDE:PYRIMIDINE DEOXYRIBOSYLTRANSFERASE ACTIVITY OF THREE PARTIALLY PURIFIED THYMIDINE PHOSPHORYLASES. |
Journal |
J Biol Chem 239:2622-7 (1964) |
Other DBs |
ExplorEnz - The Enzyme Database: | 2.4.2.4 |
ExPASy - ENZYME nomenclature database: | 2.4.2.4 |
BRENDA, the Enzyme Database: | 2.4.2.4 |
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LinkDB |
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