| Entry |
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| Name |
hypoxanthine phosphoribosyltransferase;
IMP pyrophosphorylase;
transphosphoribosidase;
hypoxanthine---guanine phosphoribosyltransferase;
guanine phosphoribosyltransferase;
GPRT;
HPRT;
guanosine 5'-phosphate pyrophosphorylase;
IMP-GMP pyrophosphorylase;
HGPRTase;
6-hydroxypurine phosphoribosyltransferase;
6-mercaptopurine phosphoribosyltransferase;
GMP pyrophosphorylase;
guanine-hypoxanthine phosphoribosyltransferase;
guanosine phosphoribosyltransferase;
guanylate pyrophosphorylase;
guanylic pyrophosphorylase;
inosinate pyrophosphorylase;
inosine 5'-phosphate pyrophosphorylase;
inosinic acid pyrophosphorylase;
inosinic pyrophosphorylase;
purine-6-thiol phosphoribosyltransferase
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| Class |
Transferases;
Glycosyltransferases;
Pentosyltransferases
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| Sysname |
IMP:diphosphate phospho-D-ribosyltransferase
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| Reaction(IUBMB) |
IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate [RN: R01132]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
hypoxanthine [CPD: C00262];
5-phospho-alpha-D-ribose 1-diphosphate [CPD: C00119]
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| Comment |
Guanine and purine-6-thiol can replace hypoxanthine.
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| History |
EC 2.4.2.8 created 1961, modified 1982
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| Pathway |
| ec00983 | Drug metabolism - other enzymes |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K00760 | hypoxanthine phosphoribosyltransferase |
| K15780 | bifunctional protein TilS/HprT |
| K19836 | hypoxanthine phosphoribosyltransferase |
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| Genes |
» show all
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| Reference |
1 |
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| Authors |
Flaks, J.G. |
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| Title |
Nucleotide synthesis from 5-phosphoribosylpyrophosphate. |
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| Journal |
Methods Enzymol 6:136-158 (1963) |
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| Reference |
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| Authors |
KORNBERG A, LIEBERMAN I, SIMMS ES. |
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| Title |
Enzymatic synthesis of purine nucleotides. |
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| Journal |
J Biol Chem 215:417-27 (1955) |
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| Reference |
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| Authors |
LUKENS LN, HERRINGTON KA. |
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| Title |
Enzymic formation of 6-mercaptopurine tibo tide. |
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| Journal |
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| Reference |
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| Authors |
REMY CN, REMY WT, BUCHANAN JM. |
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| Title |
Biosynthesis of the purines. VIII. Enzymatic synthesis and utilization of alpha-5-phosphoribosylpyrophosphate. |
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| Journal |
J Biol Chem 217:885-95 (1955) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.4.2.8 |
| ExPASy - ENZYME nomenclature database: | 2.4.2.8 |
| BRENDA, the Enzyme Database: | 2.4.2.8 |
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| LinkDB |
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