KEGG   ENZYME: 2.4.99.1
Entry
EC 2.4.99.1                 Enzyme                                 

Name
beta-galactoside alpha-(2,6)-sialyltransferase;
ST6Gal-I;
CMP-N-acetylneuraminate:beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine alpha-2,6-N-acetylneuraminyltransferase;
lactosylceramide alpha-2,6-N-sialyltransferase;
CMP-N-acetylneuraminate:beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine alpha-(2->6)-N-acetylneuraminyltransferase;
beta-galactoside alpha-2,6-sialyltransferase
Class
Transferases;
Glycosyltransferases;
Transferring other glycosyl groups
Sysname
CMP-N-acetyl-beta-neuraminate:beta-D-galactoside alpha-(2->6)-N-acetylneuraminyltransferase (configuration-inverting)
Reaction(IUBMB)
CMP-N-acetyl-beta-neuraminate + beta-D-galactosyl-R = CMP + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-R [RN:R04532 R06188]
Reaction(KEGG)
R04532 R06188(G);
(other) R03489 R05580 R05905(G) R05906(G) R05990(G) R06121(G) R09298(G)
Substrate
CMP-N-acetyl-beta-neuraminate [CPD:C00128];
beta-D-galactosyl-R [CPD:C02900]
Product
CMP [CPD:C00055];
N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-R
Comment
The enzyme acts on the terminal non-reducing beta-D-galactosyl residue of the oligosaccharide moiety of glycoproteins and glycolipids.
History
EC 2.4.99.1 created 1972, modified 1976, modified 1986, modified 2016 (EC 2.4.99.11 created 1992, incorporated 2016), modified 2017
Pathway
ec00510  N-Glycan biosynthesis
ec00514  Other types of O-glycan biosynthesis
ec01100  Metabolic pathways
Orthology
K00778  beta-galactoside alpha-2,6-sialyltransferase (sialyltransferase 1)
K00779  beta-galactoside alpha-2,6-sialyltransferase (sialyltransferase 2)
K12248  beta-galactoside alpha-2,6-sialyltransferase (sialyltransferase 0160)
Genes
HSA: 6480(ST6GAL1) 84620(ST6GAL2)
PTR: 450198(ST6GAL2) 460922(ST6GAL1)
PPS: 100969795(ST6GAL1) 100981465(ST6GAL2)
GGO: 101129847(ST6GAL2) 101142727(ST6GAL1)
PON: 100174088(ST6GAL1) 100456090(ST6GAL2)
NLE: 100580010(ST6GAL2) 100599869(ST6GAL1)
MCC: 708113(ST6GAL1) 713552(ST6GAL2)
MCF: 102121444(ST6GAL1) 102142751(ST6GAL2)
CSAB: 103241198(ST6GAL2) 103241877(ST6GAL1)
RRO: 104660586(ST6GAL2) 104682948(ST6GAL1)
RBB: 108512469(ST6GAL2) 108530462(ST6GAL1)
CJC: 100408699(ST6GAL1) 100411939(ST6GAL2)
SBQ: 101032294(ST6GAL1) 101047107(ST6GAL2)
MMU: 20440(St6gal1) 240119(St6gal2)
MCAL: 110284258(St6gal2) 110311654(St6gal1)  
MPAH: 110329758(St6gal1) 110335627(St6gal2)
RNO: 25197(St6gal1) 301155(St6gal2)
MUN: 110548122(St6gal1) 110560861(St6gal2)
CGE: 100689389(St6gal1) 100763756(St6gal2)
NGI: 103726632(St6gal2) 103750114(St6gal1)
HGL: 101718025(St6gal1) 101722644(St6gal2)
CCAN: 109691378(St6gal1) 109701499(St6gal2)
OCU: 100353188(ST6GAL1) 100358153(ST6GAL2)
TUP: 102500330(ST6GAL2)
CFA: 478668(ST6GAL1) 481315(ST6GAL2)
VVP: 112915370(ST6GAL2) 112926300(ST6GAL1)  
AML: 100478457(ST6GAL2) 100481066(ST6GAL1)
UMR: 103670658(ST6GAL2) 103676045(ST6GAL1)
UAH: 113253796(ST6GAL1) 113267699(ST6GAL2)
ORO: 101374165(ST6GAL2) 101377549(ST6GAL1)
FCA: 101097832(ST6GAL1) 101098620(ST6GAL2)
PTG: 102956769(ST6GAL1) 102962032(ST6GAL2)  
PPAD: 109254527(ST6GAL2) 109275279(ST6GAL1)
AJU: 106968006(ST6GAL1) 106977960(ST6GAL2)
BTA: 282073(ST6GAL1) 493992(ST6GAL2)
BOM: 102273022(ST6GAL1) 102285977(ST6GAL2)
BIU: 109556984(ST6GAL1) 109566122(ST6GAL2)
BBUB: 102400138(ST6GAL1) 102408407(ST6GAL2)
CHX: 100861310(ST6GAL1) 102179776(ST6GAL2)
OAS: 100913159(ST6GAL1) 101108300(ST6GAL2) 114113140
SSC: 100302026(ST6GAL1) 100512775(ST6GAL2)
CFR: 102508797(ST6GAL2) 102512873(ST6GAL1)
CDK: 105085840(ST6GAL1) 105099139(ST6GAL2)
BACU: 103009068(ST6GAL2) 103012200(ST6GAL1)
LVE: 103073782(ST6GAL2) 103086030(ST6GAL1)
OOR: 101273721(ST6GAL2) 101285111(ST6GAL1)
DLE: 111172829(ST6GAL1) 111187445(ST6GAL2)
PCAD: 102984003(ST6GAL2) 102992136(ST6GAL1)
ECB: 100059539(ST6GAL1) 100062033(ST6GAL2)
EPZ: 103555423(ST6GAL2) 103567256(ST6GAL1)
EAI: 106829390(ST6GAL2) 106832544(ST6GAL1)
MYB: 102241174(ST6GAL2) 102244256(ST6GAL1)
MYD: 102753980(ST6GAL1) 102768324(ST6GAL2)
MNA: 107527306(ST6GAL1) 107528699(ST6GAL2)
HAI: 109375943(ST6GAL2) 109396927(ST6GAL1)
DRO: 112297515(ST6GAL2) 112308352(ST6GAL1)
PALE: 102886717(ST6GAL1) 102890603(ST6GAL2)  
RAY: 107497054(ST6GAL2) 107505891(ST6GAL1)
MJV: 108388564 108401260(ST6GAL1)
LAV: 100660981(ST6GAL2) 100664378(ST6GAL1)
MDO: 100019249(ST6GAL2) 100617174(ST6GAL1)
SHR: 100922140(ST6GAL1) 100932183(ST6GAL2)
PCW: 110209426(ST6GAL2) 110221205(ST6GAL1)
OAA: 100077134(ST6GAL2) 100093341(ST6GAL1)
GGA: 396169(ST6GAL1) 403122(ST6GAL2)
MGP: 100545097(ST6GAL2) 100548556 104909223(ST6GAL1)
CJO: 107306533(ST6GAL2) 107317947(ST6GAL1)
NMEL: 110397396(ST6GAL1) 110406996(ST6GAL2)  
APLA: 101796015(ST6GAL2) 101803267(ST6GAL1)
ACYG: 106040277(ST6GAL1) 106041658(ST6GAL2)
TGU: 100226346(ST6GAL1) 100230425(ST6GAL2)
LSR: 110478726(ST6GAL2) 110484834(ST6GAL1)
SCAN: 103812379(ST6GAL2) 103815542(ST6GAL1)
GFR: 102038321(ST6GAL2) 102042024(ST6GAL1)
FAB: 101810086(ST6GAL2) 101820079(ST6GAL1)
PHI: 102107561(ST6GAL1) 102109099(ST6GAL2)
PMAJ: 107208898(ST6GAL1) 107211419(ST6GAL2)
CCAE: 111922685(ST6GAL2) 111933760(ST6GAL1)
CCW: 104686087(ST6GAL2) 104693051(ST6GAL1)
ETL: 114057719(ST6GAL1) 114066979(ST6GAL2)
FPG: 101914140(ST6GAL2) 101924763(ST6GAL1)
FCH: 102056735(ST6GAL2) 102058385(ST6GAL1)
CLV: 102087342(ST6GAL2) 102097093(ST6GAL1)
EGZ: 104126364(ST6GAL2) 104135489(ST6GAL1)
NNI: 104019355(ST6GAL2) 104023676(ST6GAL1)
ACUN: 113481283(ST6GAL2) 113483390(ST6GAL1)
PADL: 103912776(ST6GAL1) 103918841(ST6GAL2)
AAM: 106494052(ST6GAL2) 106496189(ST6GAL1)
ASN: 102372316(ST6GAL2) 102373489(ST6GAL1)
AMJ: 102569903(ST6GAL2) 102575767(ST6GAL1)
PSS: 102446128(ST6GAL1) 102453477(ST6GAL2)
CMY: 102941507 102943395(ST6GAL2)
CPIC: 101939719 101943605(ST6GAL1) 101950728(ST6GAL2)
ACS: 100529108(st6gal2) 100529109(st6gal1)
PVT: 110074124(ST6GAL2) 110088940(ST6GAL1)
PBI: 103061620(ST6GAL1) 103062404(ST6GAL2)
PMUR: 107286474 107288840(ST6GAL2)
TSR: 106540309(ST6GAL2) 106545885 106550706(ST6GAL1)
PMUA: 114595050 114596422(ST6GAL2) 114597762(ST6GAL1)
GJA: 107110554(ST6GAL1) 107115211 107125130(ST6GAL2)
XLA: 108708393(st6gal2.L) 108709694(st6gal2.S) 108717116(st6gal1.L) 108718183(st6gal1.S)
XTR: 100491268(st6gal1) 407846(st6gal2)
NPR: 108785132(ST6GAL2) 108785675(ST6GAL1)
DRE: 403116(st6gal2a) 445376(st6gal1) 797439(st6gal2b)
PHYP: 113525857(st6gal2) 113538434 113541806
AMEX: 103024101(st6gal2) 103030360 103031874
EEE: 113574044 113576168(st6gal1) 113584885(st6gal2)
TRU: 445982(st6gal1) 777969(st6gal2)
NCC: 104957421(st6gal2)
MZE: 101464130(st6gal2) 101466910
ONL: 100694560 100704184(st6gal2)
OLA: 100049380(st6gal1) 100049381(st6gal2)
XMA: 102229475(st6gal2) 102231535
XCO: 114148521(st6gal2) 114152599
PRET: 103476390 103480039(st6gal2)
CVG: 107090303 107096899(st6gal2)
NFU: 107384328 107389803(st6gal2)  
ALIM: 106514590 106514661 106519824(st6gal2)
AOCE: 111563401(st6gal1) 111570337 111582969(st6gal2)
CSEM: 103391691(st6gal2)
POV: 109631344(st6gal2)
LCF: 108881134 108901078(st6gal2)
SDU: 111218195(st6gal2)
SLAL: 111646873 111662108(st6gal2)
HCQ: 109530661(st6gal2)
MALB: 109965389(st6gal2)
CMK: 103172241(st6gal2) 103174913(st6gal1)  
DME: Dmel_CG4871(SiaT)
DER: 6548509
DSE: 6618867
DSI: Dsimw501_GD24925(Dsim_ST6Gal)
DYA: Dyak_GE11423(Dyak_ST6Gal)
DAN: 6507957
DSR: 110178056
DPO: Dpse_GA18492(Dpse_ST6Gal)
DPE: 6592954
DMN: 108158215
DWI: 6640266
DGR: Dgri_GH21565(Dgri_ST6Gal)
DMO: Dmoj_GI19537(Dmoj_ST6Gal)
DAZ: 108614840
DNV: 108654327
DHE: 111593949
DVI: 6625423
MDE: 101891865
LCQ: 111681785
AAG: 5566828
NVL: 108563142
BMOR: 101744994
PMAC: 106712367
PRAP: 111002097
HAW: 110369814
TNL: 113492654
AGS: 114127655
ZNE: 110834803
TUT: 107362587
CSCU: 111636481
PTEP: 107450093
HDU: HD_0053
PMU: PM0188
PMP: Pmu_11250
PMUL: DR93_1878
SWP: swp_5060
 » show all
Reference
1  [PMID:5726897]
  Authors
Spiro MJ, Spiro RG.
  Title
Glycoprotein biosynthesis: studies on thyroglobulin. Thyroid sialyltransferase.
  Journal
J Biol Chem 243:6520-8 (1968)
Reference
2  [PMID:4313609]
  Authors
Hickman J, Ashwell G, Morell AG, van den Hamer CJ, Scheinberg IH.
  Title
Physical and chemical studies on ceruloplasmin. 8. Preparation of N-acetylneuraminic acid-1-14C-labeled ceruloplasmin.
  Journal
J Biol Chem 245:759-66 (1970)
Reference
3  [PMID:4723915]
  Authors
Bartholomew BA, Jourdian GW, Roseman S.
  Title
The sialic acids. XV. Transfer of sialic acid to glycoproteins by a sialyltransferase from colostrum.
  Journal
J Biol Chem 248:5751-62 (1973)
Reference
4  [PMID:849932]
  Authors
Paulson JC, Beranek WE, Hill RL.
  Title
Purification of a sialyltransferase from bovine colostrum by affinity chromatography on CDP-agarose.
  Journal
J Biol Chem 252:2356-62 (1977)
Reference
5  [PMID:6366476]
  Authors
Schachter H, Narasimhan S, Gleeson P, Vella G.
  Title
Glycosyltransferases involved in elongation of N-glycosidically linked oligosaccharides of the complex or N-acetyllactosamine type.
  Journal
Methods Enzymol 98:98-134 (1983)
DOI:10.1016/0076-6879(83)98143-0
Reference
6  [PMID:2460092]
  Authors
Albarracin I, Lassaga FE, Caputto R.
  Title
Purification and characterization of an endogenous inhibitor of the sialyltransferase CMP-N-acetylneuraminate: lactosylceramide alpha 2,6-N-acetylneuraminyltransferase (EC 2.4.99.-).
  Journal
Biochem J 254:559-65 (1988)
DOI:10.1042/bj2540559
Other DBs
ExplorEnz - The Enzyme Database: 2.4.99.1
IUBMB Enzyme Nomenclature: 2.4.99.1
ExPASy - ENZYME nomenclature database: 2.4.99.1
BRENDA, the Enzyme Database: 2.4.99.1
CAS: 9075-81-4
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