Entry |
|
Name |
(Kdo)-lipid IVA 3-deoxy-D-manno-octulosonic acid transferase;
Kdo transferase;
waaA (gene name);
kdtA (gene name);
3-deoxy-D-manno-oct-2-ulosonic acid transferase;
3-deoxy-manno-octulosonic acid transferase;
(KDO)-lipid IVA 3-deoxy-D-manno-octulosonic acid transferase
|
Class |
Transferases;
Glycosyltransferases;
Transferring other glycosyl groups
|
Sysname |
CMP-3-deoxy-D-manno-oct-2-ulosonate:(Kdo)-lipid IVA 3-deoxy-D-manno-oct-2-ulosonate transferase
|
Reaction(IUBMB) |
alpha-Kdo-(2->6)-lipid IVA + CMP-beta-Kdo = alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP [RN: R05074 R06285]
|
Reaction(KEGG) |
|
Substrate |
alpha-Kdo-(2->6)-lipid IVA;
CMP-beta-Kdo [CPD: C04121]
|
Product |
alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA;
CMP [CPD: C00055]
|
Comment |
The bifunctional enzyme from Escherichia coli transfers two 3-deoxy-D-manno-oct-2-ulosonate residues to lipid IVA (cf. EC 2.4.99.12 [lipid IVA 3-deoxy-D-manno-octulosonic acid transferase]) [1]. The enzymes from Chlamydia transfer three or more 3-deoxy-D-manno-oct-2-ulosonate residues and generate genus-specific epitopes [4].
|
History |
EC 2.4.99.13 created 2010, modified 2011
|
Pathway |
ec00540 | Lipopolysaccharide biosynthesis |
|
Orthology |
K02527 | 3-deoxy-D-manno-octulosonic-acid transferase |
|
Genes |
» show all
|
Reference |
|
Authors |
Belunis CJ, Raetz CR |
Title |
Biosynthesis of endotoxins. Purification and catalytic properties of 3-deoxy-D-manno-octulosonic acid transferase from Escherichia coli. |
Journal |
J Biol Chem 267:9988-97 (1992) |
Sequence |
|
Reference |
|
Authors |
Lobau S, Mamat U, Brabetz W, Brade H |
Title |
Molecular cloning, sequence analysis, and functional characterization of the lipopolysaccharide biosynthetic gene kdtA encoding 3-deoxy-alpha-D-manno-octulosonic acid transferase of Chlamydia pneumoniae strain TW-183. |
Journal |
|
Sequence |
|
Other DBs |
ExPASy - ENZYME nomenclature database: | 2.4.99.13 |
|
LinkDB |
|