Entry |
|
Name |
(Kdo)2-lipid IVA (2-8) 3-deoxy-D-manno-octulosonic acid transferase;
Kdo transferase;
waaA (gene name);
kdtA (gene name);
3-deoxy-D-manno-oct-2-ulosonic acid transferase;
3-deoxy-manno-octulosonic acid transferase;
(KDO)2-lipid IVA (2-8) 3-deoxy-D-manno-octulosonic acid transferase
|
Class |
Transferases;
Glycosyltransferases;
Transferring other glycosyl groups
|
Sysname |
CMP-3-deoxy-D-manno-oct-2-ulosonate:(Kdo)2-lipid IVA 3-deoxy-D-manno-oct-2-ulosonate transferase [(2->8) glycosidic bond-forming]
|
Reaction(IUBMB) |
alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-beta-Kdo = alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP [RN: R09763 R09764]
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Reaction(KEGG) |
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Substrate |
alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA;
CMP-beta-Kdo [CPD: C04121]
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Product |
alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA [CPD: C19875];
CMP [CPD: C00055]
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Comment |
The enzymes from Chlamydia transfer three or more 3-deoxy-D-manno-oct-2-ulosonate residues and generate genus-specific epitopes.
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History |
EC 2.4.99.14 created 2010, modified 2011
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Orthology |
K02527 | 3-deoxy-D-manno-octulosonic-acid transferase |
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Genes |
» show all
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Reference |
|
Authors |
Lobau S, Mamat U, Brabetz W, Brade H |
Title |
Molecular cloning, sequence analysis, and functional characterization of the lipopolysaccharide biosynthetic gene kdtA encoding 3-deoxy-alpha-D-manno-octulosonic acid transferase of Chlamydia pneumoniae strain TW-183. |
Journal |
|
Sequence |
|
Reference |
|
Authors |
Mamat U, Baumann M, Schmidt G, Brade H |
Title |
The genus-specific lipopolysaccharide epitope of Chlamydia is assembled in C. psittaci and C. trachomatis by glycosyltransferases of low homology. |
Journal |
|
Sequence |
|
Reference |
|
Authors |
Belunis CJ, Mdluli KE, Raetz CR, Nano FE |
Title |
A novel 3-deoxy-D-manno-octulosonic acid transferase from Chlamydia trachomatis required for expression of the genus-specific epitope. |
Journal |
J Biol Chem 267:18702-7 (1992) |
Sequence |
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Other DBs |
ExPASy - ENZYME nomenclature database: | 2.4.99.14 |
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LinkDB |
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