| Entry |
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| Name |
N,N'-diacetyllegionaminate synthase;
neuB (gene name);
legI (gene name)
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| Class |
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
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| Sysname |
phosphoenolpyruvate:2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose 1-(2-carboxy-2-oxoethyl)transferase
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| Reaction(IUBMB) |
2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + phosphoenolpyruvate + H2O = N,N'-diacetyllegionaminate + phosphate [RN: R10304]
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| Reaction(KEGG) |
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| Substrate |
2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose [CPD: C20424];
phosphoenolpyruvate [CPD: C00074];
H2O [CPD: C00001]
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| Product |
N,N'-diacetyllegionaminate [CPD: C20418];
phosphate [CPD: C00009]
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| Comment |
Requires a divalent metal such as Mn2+. Isolated from the bacteria Legionella pneumophila and Campylobacter jejuni, where it is involved in the biosynthesis of legionaminic acid, a virulence-associated, cell surface sialic acid-like derivative.
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| History |
EC 2.5.1.101 created 2012
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| Pathway |
| ec00520 | Amino sugar and nucleotide sugar metabolism |
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| Orthology |
| K18430 | N,N'-diacetyllegionaminate synthase |
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| Genes |
» show all
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| Reference |
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| Authors |
Glaze PA, Watson DC, Young NM, Tanner ME |
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| Title |
Biosynthesis of CMP-N,N'-diacetyllegionaminic acid from UDP-N,N'-diacetylbacillosamine in Legionella pneumophila. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Schoenhofen IC, Vinogradov E, Whitfield DM, Brisson JR, Logan SM |
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| Title |
The CMP-legionaminic acid pathway in Campylobacter: biosynthesis involving novel GDP-linked precursors. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.5.1.101 |
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| LinkDB |
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