| Entry |
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| Name |
geranyl-pyrophosphate---olivetolic acid geranyltransferase;
GOT (ambiguous)
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| Class |
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
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| Sysname |
geranyl-diphosphate:olivetolate geranyltransferase
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| Reaction(IUBMB) |
geranyl diphosphate + 2,4-dihydroxy-6-pentylbenzoate = diphosphate + cannabigerolate [RN: R10176]
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| Reaction(KEGG) |
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| Substrate |
geranyl diphosphate [CPD: C00341];
2,4-dihydroxy-6-pentylbenzoate [CPD: C20417]
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| Product |
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| Comment |
Part of the cannabinoids biosynthetic pathway of the plant Cannabis sativa. The enzyme can also use neryl diphosphate as substrate, forming cannabinerolate.
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| History |
EC 2.5.1.102 created 2012
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| Pathway |
| ec00999 | Biosynthesis of various secondary metabolites - part 1 |
| ec01110 | Biosynthesis of secondary metabolites |
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| Reference |
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| Authors |
Fellermeier M, Zenk MH |
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| Title |
Prenylation of olivetolate by a hemp transferase yields cannabigerolic acid, the precursor of tetrahydrocannabinol. |
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| Journal |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.5.1.102 |
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| LinkDB |
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