| Entry |
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| Name |
tryprostatin B synthase;
ftmPT1 (gene name);
brevianamide F prenyltransferase (ambiguous)
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| Class |
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
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| Sysname |
dimethylallyl-diphosphate:brevianamide-F dimethylallyl-C-2-transferase
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| Reaction(IUBMB) |
dimethylallyl diphosphate + brevianamide F = diphosphate + tryprostatin B [RN: R10340]
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| Reaction(KEGG) |
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| Substrate |
dimethylallyl diphosphate [CPD: C00235];
brevianamide F [CPD: C20563]
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| Product |
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| Comment |
The enzyme from the fungus Aspergillus fumigatus can also prenylate other tryptophan-containing cyclic dipeptides. Prenylation occurs mainly at C-2 [1], but also at C-3 [2]. Involved in the biosynthetic pathways of several indole alkaloids such as tryprostatins, cyclotryprostatins, spirotryprostatins, fumitremorgins and verruculogen.
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| History |
EC 2.5.1.106 created 2013
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| Pathway |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K14132 | tryprostatin B synthase |
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| Genes |
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| Reference |
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| Authors |
Grundmann A, Li SM |
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| Title |
Overproduction, purification and characterization of FtmPT1, a brevianamide F prenyltransferase from Aspergillus fumigatus. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Wollinsky B, Ludwig L, Xie X, Li SM |
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| Title |
Breaking the regioselectivity of indole prenyltransferases: identification of regular C3-prenylated hexahydropyrrolo[2,3-b]indoles as side products of the regular C2-prenyltransferase FtmPT1. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.5.1.106 |
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| LinkDB |
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