| Entry |
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| Name |
homogentisate geranylgeranyltransferase;
HGGT;
slr1736 (gene name)
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| Class |
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
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| Sysname |
geranylgeranyl diphosphate:homogentisate geranylgeranyltransferase
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| Reaction(IUBMB) |
geranylgeranyl diphosphate + homogentisate = diphosphate + 6-geranylgeranyl-2-methylbenzene-1,4-diol + CO2 [RN: R10708]
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| Reaction(KEGG) |
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| Substrate |
geranylgeranyl diphosphate [CPD: C00353];
homogentisate [CPD: C00544]
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| Product |
diphosphate [CPD: C00013];
6-geranylgeranyl-2-methylbenzene-1,4-diol [CPD: C20737];
CO2 [CPD: C00011]
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| Comment |
Requires Mg2+ for activity. Involved in the biosynthesis of the vitamin E, tocotrienols. While the enzyme from the bacterium Synechocystis PCC 6803 has higher activity with phytyl diphosphate (EC 2.5.1.115, homogentisate phytyltransferase), the enzymes from barley, rice and wheat have only a low activity with that substrate [2].
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| History |
EC 2.5.1.116 created 2014
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| Pathway |
| ec00130 | Ubiquinone and other terpenoid-quinone biosynthesis |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K09833 | homogentisate phytyltransferase / homogentisate geranylgeranyltransferase |
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| Genes |
» show all
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| Reference |
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| Authors |
Collakova E, DellaPenna D |
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| Title |
Isolation and functional analysis of homogentisate phytyltransferase from Synechocystis sp. PCC 6803 and Arabidopsis. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Cahoon EB, Hall SE, Ripp KG, Ganzke TS, Hitz WD, Coughlan SJ |
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| Title |
Metabolic redesign of vitamin E biosynthesis in plants for tocotrienol production and increased antioxidant content. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Yang W, Cahoon RE, Hunter SC, Zhang C, Han J, Borgschulte T, Cahoon EB |
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| Title |
Vitamin E biosynthesis: functional characterization of the monocot homogentisate geranylgeranyl transferase. |
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| Journal |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.5.1.116 |
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| LinkDB |
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