| Entry |
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| Name |
beta-(isoxazolin-5-on-4-yl)-L-alanine synthase
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| Class |
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
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| Sysname |
O-acetyl-L-serine:isoxazolin-5-one 4-(2-amino-2-carboxyethyl)transferase
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| Reaction(IUBMB) |
O-acetyl-L-serine + isoxazolin-5-one = 3-(5-oxoisoxazolin-4-yl)-L-alanine + acetate [RN: R10840]
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| Reaction(KEGG) |
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| Substrate |
O-acetyl-L-serine [CPD: C00979];
isoxazolin-5-one [CPD: C20891]
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| Product |
3-(5-oxoisoxazolin-4-yl)-L-alanine [CPD: C20893];
acetate [CPD: C00033]
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| Comment |
3-(5-Oxoisoxazolin-4-yl)-L-alanine is an antifungal antibiotic produced by the bacterium Streptomyces platensis. The enzymes from the plants Lathyrus odoratus (sweet pea), L. sativus (grass pea) and Citrullus vulgaris (watermelon) that catalyse EC 2.5.1.118 (beta-(isoxazolin-5-on-2-yl)-L-alanine synthase) also catalyse this reaction in vitro, but not in vivo. Closely related and possibly identical to EC 2.5.1.47, cysteine synthase, and EC 2.5.1.51, beta-pyrazolylalanine synthase.
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| History |
EC 2.5.1.119 created 2014
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| Reference |
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| Authors |
Ikegami F, Kamiya M, Kuo YH, Lambein F, Murakoshi I |
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| Title |
Enzymatic synthesis of two isoxazolylalanine isomers by cysteine synthases in Lathyrus species. |
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| Journal |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.5.1.119 |
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| LinkDB |
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