KEGG   ENZYME: 2.5.1.130
Entry
EC 2.5.1.130                Enzyme                                 

Name
2-carboxy-1,4-naphthoquinone phytyltransferase;
menA (gene name);
ABC4 (gene name);
1,4-dioxo-2-naphthoate phytyltransferase;
1,4-diketo-2-naphthoate phytyltransferase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
phytyl-diphosphate:2-carboxy-1,4-naphthoquinone phytyltransferase
Reaction(IUBMB)
phytyl diphosphate + 2-carboxy-1,4-naphthoquinone = demethylphylloquinone + diphosphate + CO2 [RN:R12255]
Reaction(KEGG)
R12255
Substrate
phytyl diphosphate [CPD:C05427];
2-carboxy-1,4-naphthoquinone [CPD:C22039]
Product
demethylphylloquinone [CPD:C13309];
diphosphate [CPD:C00013];
CO2 [CPD:C00011]
Comment
This enzyme, found in plants and cyanobacteria, catalyses a step in the synthesis of phylloquinone (vitamin K1), an electron carrier associated with photosystem I. The enzyme catalyses the transfer of the phytyl chain synthesized by EC 1.3.1.83, geranylgeranyl diphosphate reductase, to 2-carboxy-1,4-naphthoquinone.
History
EC 2.5.1.130 created 2015
Pathway
ec00130  Ubiquinone and other terpenoid-quinone biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K23094  2-carboxy-1,4-naphthoquinone phytyltransferase
Genes
ATH: AT1G60600(ABC4)
ALY: 9322672
CRB: 17895973
CSAT: 104703646 104787111
EUS: EUTSA_v10023528mg
BRP: 103829906
BNA: 106435024
BOE: 106323857
RSZ: 108809221
THJ: 104799883
CPAP: 110816205
CIT: 102624098
TCC: 18608257
GRA: 105795089
GAB: 108474800
DZI: 111295322
VRA: 106773008
VAR: 108322207
VUN: 114176967
CCAJ: 109804803
CAM: 101504086
LJA: Lj4g3v0363530.1(Lj4g3v0363530.1) Lj4g3v0363530.2(Lj4g3v0363530.2) Lj4g3v0363530.3(Lj4g3v0363530.3)
ADU: 107481793
AIP: 107631655
LANG: 109349268
FVE: 101307197
RCN: 112188695
PPER: 18768593
PMUM: 103336024
MDM: 103444873
ZJU: 107428571
CSV: 101221829
CMO: 103495404
MCHA: 111012238
CMAX: 111486134
CMOS: 111434556
CPEP: 111793077
RCU: 8282981
JCU: 105631592
HBR: 110646504
MESC: 110618461
POP: 7496610
PEU: 105138653
JRE: 109014828
QSU: 112029288
VVI: 100256517
SLY: 101248721
SPEN: 107004202
SOT: 102602396
CANN: 107840062
NSY: 104224950
NTO: 104097428
NAU: 109223878
INI: 109167145
OEU: 111394670
HAN: 110885784
LSV: 111913253
CCAV: 112516996
DCR: 108205031
BVG: 104904058
SOE: 110802488
NNU: 104604508
OSA: 4331897
DOSA: Os03t0190100-01(Os03g0190100)
OBR: 102718997
BDI: 100820840
ATS: 109755307(LOC109755307) 109756016(LOC109756016)
SBI: 8081915
ZMA: 100285808
SITA: 101782427
PDA: 103717960
EGU: 105041933
MUS: 103971313
DCT: 110102149
PEQ: 110025986
AOF: 109835033
PPP: 112292862
APRO: F751_5387
SYN: slr1518(menA)
SYZ: MYO_114670(menA)
SYY: SYNGTS_1454(menA)
SYT: SYNGTI_1454(menA)
SYS: SYNPCCN_1453(menA)
SYQ: SYNPCCP_1453(menA)
SYJ: D082_13930(menA)
SYO: C7I86_07530(menA)
SYC: syc0189_d(menA)
SYW: SYNW2307(menA)
SYG: sync_2655(menA)
SYR: SynRCC307_2253(menA)
SYX: SynWH7803_2318(menA)
SYP: SYNPCC7002_A1984(menA)
CYA: CYA_2456(menA)
CYB: CYB_2300(menA)
SYNR: KR49_07785
SYND: KR52_03885
SYH: Syncc8109_2548(menA)
SYNW: SynWH8103_02649(menA)
TEL: tlr2196(menA)
THN: NK55_07630(menA)
TVN: NIES2134_121190(menA)
THEC: FFX45_04670(menA)
CYI: CBM981_3220(menA)
LET: O77CONTIG1_03563(menA)
HHG: XM38_049670(menA_2)
PSER: ABRG53_3629(menA)
PMA: Pro_0201(menA)
PMM: PMM0176(menA)
PMT: PMT_2059
PMB: A9601_01941(menA)
PMC: P9515_02051(menA)
PMF: P9303_27341(menA)
PMG: P9301_01961(menA)
PMH: P9215_01941(menA)
PMJ: P9211_01941(menA)
PME: NATL1_02511(menA)
PRC: EW14_0219
PRM: EW15_0265
AMR: AM1_1110(menA)
MAR: MAE_35650(menA)
MPK: VL20_5668
MVZ: myaer102_10780(menA)
CYL: AA637_12770(menA)
CYT: cce_4479(menA)
TER: Tery_4071
ARP: NIES39_C00320(menA)
PAGH: NIES204_17120(menA)
GVI: gvip220(menA)
GLJ: GKIL_2377(menA)
ANA: alr0033(menA)
NSH: GXM_01462
AVA: Ava_2633
NAZ: Aazo_1394
ANB: ANA_C12891(menA)
CALH: IJ00_14510
NSP: BMF81_03398(menA)
DOU: BMF77_04485(menA)
CTHE: Chro_4086
 » show all
Reference
1  [PMID:10722690]
  Authors
Johnson TW, Shen G, Zybailov B, Kolling D, Reategui R, Beauparlant S, Vassiliev IR, Bryant DA, Jones AD, Golbeck JH, Chitnis PR
  Title
Recruitment of a foreign quinone into the A(1) site of photosystem I. I. Genetic  and physiological characterization of phylloquinone biosynthetic pathway mutants  in Synechocystis sp. pcc 6803.
  Journal
J Biol Chem 275:8523-30 (2000)
DOI:10.1074/jbc.275.12.8523
  Sequence
[syn:slr1518]
Reference
2  [PMID:15686525]
  Authors
Shimada H, Ohno R, Shibata M, Ikegami I, Onai K, Ohto MA, Takamiya K
  Title
Inactivation and deficiency of core proteins of photosystems I and II caused by genetical phylloquinone and plastoquinone deficiency but retained lamellar structure in a T-DNA mutant of Arabidopsis.
  Journal
Plant J 41:627-37 (2005)
DOI:10.1111/j.1365-313X.2004.02326.x
  Sequence
[ath:AT1G60600]
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.130
IUBMB Enzyme Nomenclature: 2.5.1.130
ExPASy - ENZYME nomenclature database: 2.5.1.130
BRENDA, the Enzyme Database: 2.5.1.130
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