| Entry |
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| Name |
3-deoxy-D-glycero-D-galacto-nonulopyranosonate 9-phosphate synthase;
3-deoxy-D-glycero-D-galacto-nononate 9-phosphate synthase;
2-keto-3-deoxy-D-glycero-D-galacto-9-phosphonononic acid synthase;
Kdn 9-P synthase
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| Class |
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
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| Sysname |
phosphoenolpyruvate:D-mannose-6-phosphate 1-(2-carboxy-2-oxoethyl)transferase
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| Reaction(IUBMB) |
phosphoenolpyruvate + D-mannose 6-phosphate + H2O = 3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate 9-phosphate + phosphate [RN: R11439]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate 9-phosphate;
phosphate [CPD: C00009]
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| Comment |
The enzyme participates in the biosynthesis of the sialic acid 3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate (Kdn). The human sialic acid synthase (EC 2.5.1.57) is also able to catalyse the reaction. Kdn is abundant in extracellular glycoconjugates of lower vertebrates such as fish and amphibians, but is also found in the capsular polysaccharides of bacteria that belong to the Bacteroides genus.
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| History |
EC 2.5.1.132 created 2016
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| Orthology |
| K21279 | 3-deoxy-D-glycero-D-galacto-nononate 9-phosphate synthase |
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| Genes |
» show all
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| Reference |
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| Authors |
Angata T, Nakata D, Matsuda T, Kitajima K, Troy FA 2nd |
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| Title |
Biosynthesis of KDN (2-keto-3-deoxy-D-glycero-D-galacto-nononic acid). Identification and characterization of a KDN-9-phosphate synthetase activity from trout testis. |
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| Journal |
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| Reference |
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| Authors |
Lawrence SM, Huddleston KA, Pitts LR, Nguyen N, Lee YC, Vann WF, Coleman TA, Betenbaugh MJ |
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| Title |
Cloning and expression of the human N-acetylneuraminic acid phosphate synthase gene with 2-keto-3-deoxy-D-glycero- D-galacto-nononic acid biosynthetic ability. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Wang L, Lu Z, Allen KN, Mariano PS, Dunaway-Mariano D |
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| Title |
Human symbiont Bacteroides thetaiotaomicron synthesizes 2-keto-3-deoxy-D-glycero-D- galacto-nononic acid (KDN). |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.5.1.132 |
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| LinkDB |
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