KEGG   ENZYME: 2.5.1.135Help
Entry
EC 2.5.1.135                Enzyme                                 

Name
validamine 7-phosphate valienyltransferase;
vldE (gene name);
valL (gene name)
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
GDP-valienol:validamine 7-phosphate valienyltransferase
Reaction(IUBMB)
GDP-valienol + validamine 7-phosphate = validoxylamine A 7'-phosphate + GDP [RN:R11497]
Reaction(KEGG)
R11497 > R11239;
(other) R11250
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Substrate
GDP-valienol [CPD:C21368];
validamine 7-phosphate [CPD:C21216]
Product
validoxylamine A 7'-phosphate [CPD:C21219];
GDP [CPD:C00035]
Comment
The enzyme, characterized from several Streptomyces strains, is involved in the biosynthesis of the antifungal agent validamycin A.
History
EC 2.5.1.135 created 2016
Pathway
ec00525  Acarbose and validamycin biosynthesis
ec01100  Metabolic pathways
ec01130  Biosynthesis of antibiotics
Orthology
K20436  validamine 7-phosphate valienyltransferase
Genes
SUR: STAUR_3137
SHY: SHJG_0274
SHO: SHJGH_0108
SALS: SLNWT_0581
AMI: Amir_1997
Taxonomy
Reference
1  [PMID:21766819]
  Authors
Asamizu S, Yang J, Almabruk KH, Mahmud T.
  Title
Pseudoglycosyltransferase catalyzes nonglycosidic C-N coupling in validamycin a biosynthesis.
  Journal
J Am Chem Soc 133:12124-35 (2011)
DOI:10.1021/ja203574u
Reference
2  [PMID:22384130]
  Authors
Zheng L, Zhou X, Zhang H, Ji X, Li L, Huang L, Bai L, Zhang H.
  Title
Structural and functional analysis of validoxylamine A 7'-phosphate synthase ValL involved in validamycin A biosynthesis.
  Journal
PLoS One 7:e32033 (2012)
DOI:10.1371/journal.pone.0032033
  Sequence
[shy:SHJG_0274]
Reference
3  [PMID:23028689]
  Authors
Cavalier MC, Yim YS, Asamizu S, Neau D, Almabruk KH, Mahmud T, Lee YH
  Title
Mechanistic insights into validoxylamine A 7'-phosphate synthesis by VldE using the structure of the entire product complex.
  Journal
PLoS One 7:e44934 (2012)
DOI:10.1371/journal.pone.0044934
  Sequence
[shy:SHJG_0274]
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.135
IUBMB Enzyme Nomenclature: 2.5.1.135
ExPASy - ENZYME nomenclature database: 2.5.1.135
BRENDA, the Enzyme Database: 2.5.1.135
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