KEGG   ENZYME: 2.5.1.143
Entry
EC 2.5.1.143                Enzyme                                 

Name
pyridinium-3,5-biscarboxylic acid mononucleotide synthase;
LarB;
P2CMN synthase;
nicotinic acid adenine dinucleotide carboxylase/hydrolase;
NaAD carboxylase/hydrolase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
deamido-NAD+:hydrogencarbonate nicotinate-beta-D-ribonucleotidyltransferase
Reaction(IUBMB)
deamido-NAD+ + hydrogencarbonate = AMP + pyridinium-3,5-biscarboxylate mononucleotide [RN:R12017]
Reaction(KEGG)
R12017
Substrate
deamido-NAD+ [CPD:C00857];
hydrogencarbonate [CPD:C00288]
Product
AMP [CPD:C00020];
pyridinium-3,5-biscarboxylate mononucleotide [CPD:C21851]
Comment
This enzyme, found in the bacterium Lactobacillus plantarum, is involved in the biosynthesis of a nickel-pincer cofactor. It carboxylates the pyridinium ring of deamido-NAD+ and cleaves the phosphoanhydride bond to release AMP and generate pyridinium-3,5-biscarboxylic acid mononucleotide (P2CMN).
History
EC 2.5.1.143 created 2018
Orthology
K06898  pyridinium-3,5-biscarboxylic acid mononucleotide synthase
Genes
TCI: A7K98_01715
VSH: BSZ05_17085
EMO: DM558_01525(larB)
CATE: C2869_06450 C2869_22205
GAI: IMCC3135_06245(purE_1)
KUS: B9G99_09395
KMA: B9H00_05455
KUY: FY550_02750(larB)
SUTT: SUTMEG_10640
SUTK: FG381_03600(larB)
WSU: WS0137
CGRA: CGRAC_1982
CSPF: CSF_0735
CGEO: CGEO_0099
CMUC: CMCT_0034
SDL: Sdel_1280
SMUL: SMUL_1675
SHAL: SHALO_1630
SULJ: SJPD1_1637
SULT: FA592_00720(larB)
GSU: GSU0140
GME: Gmet_0193
GUR: Gura_0214
GLO: Glov_3164
GBM: Gbem_3625
GEO: Geob_1110
GEM: GM21_3730
GEB: GM18_4083
PCA: Pcar_2400
PPD: Ppro_0625
DEU: DBW_0927
DVU: DVU1062
DVL: Dvul_1932
DVM: DvMF_0527
DDE: Dde_1404
DDS: Ddes_2382
DMA: DMR_16540
DGG: DGI_1651
DTR: RSDT_0982
DFL: DFE_2069
DMS: E8L03_07260(larB) E8L03_08325(larB)
DSD: GD606_05115(larB)
DAS: Daes_0012
DPI: BN4_20235
PPRF: DPRO_3445
PSEL: GM415_09190(larB)
DSX: GD604_10555(larB)
DBA: Dbac_3301
DRT: Dret_2031
DPS: DP0807
DOG: HP555_06450(larB)
DSF: UWK_01647
DOL: Dole_0969
DML: Dmul_17680(purE)
DAL: Dalk_0112
DAT: HRM2_21010(purE)
DALK: DSCA_52580
ADE: Adeh_4314
MXA: MXAN_6690
SCL: sce2033
HOH: Hoch_2561
SAT: SYN_00474
SFU: Sfum_2473
DAX: FDQ92_06170(larB)
DBR: Deba_2300
BSED: DN745_16035(larB)
PCAY: FRD00_11130(larB)
SNO: Snov_3497
STAR: G3545_21880(larB)
ANC: GBB76_11555(larB)
MET: M446_3801
MOR: MOC_1718
MEE: DA075_01270(larB)
METI: DK427_11385(larB)
MMES: MMSR116_17350(larB)
MTEA: DK419_02905(larB)
BBAR: RHAL1_03400(larB)
RBM: TEF_02785
MALG: MALG_04020
LABP: FJ695_05655(larB)
SPSE: SULPSESMR1_03847(purE)
BLAS: BSY18_3646
MGM: Mmc1_0162
BAG: Bcoa_1735
BMQ: BMQ_3430
BMD: BMD_3421
OCB: CV093_14525(larB)
GKA: GK1964
GTN: GTNG_1863
HLI: HLI_15665
PBUT: DTO10_00750(larB)
GRC: GI584_07260(larB)
POF: GS400_06175(larB)
SER: SERP0254
SEP: SE0372
SEPP: SEB_00294
SEPS: DP17_1679
SSP: SSP0175
SPAS: STP1_1686
SCAR: DWB96_11240(larB)
SARL: SAP2_03230
PMW: B2K_05185
PPSC: EHS13_07750(larB)
COH: EAV92_16195(larB)
COHN: KCTCHS21_48030(larB)
AAD: TC41_0791
SPAE: E2C16_10310(larB)
PANC: E2636_15530(larB)
LCS: LCBD_p40
LPL: lp_0105(larB)
LPJ: JDM1_0106
LPT: zj316_0314(larB)
LPZ: Lp16_0098
LFE: LAF_1732
LFR: LC40_1100
LFF: LBFF_1914
LMAL: LM596_00645(larB)
LBR: LVIS_1850
LSUA: H3M12_11160(larB)
LNN: F0161_06430(larB)
PPE: PEPE_1693
PPEN: T256_08330
PCE: PECL_1782
LSA: LCA_0785
LGM: LG542_05680(larB) LG542_08130(larB)
EGV: EGCR1_11155(larB) EGCR1_12075(larB)
ESG: EsVE80_25540(larB)
CAC: CA_C0776
CAE: SMB_G0792
CAY: CEA_G0787
CBO: CBO0105
CBA: CLB_0141
CBH: CLC_0153
CBY: CLM_0148
CBL: CLK_3280
CBB: CLD_0681
CBI: CLJ_B0143
CBF: CLI_0160
CBM: CBF_0133
CBE: Cbei_0561
CBZ: Cbs_0561
CBEI: LF65_00622
CKL: CKL_0329
CKR: CKR_0281
CPAS: Clopa_0771
CBV: U729_1765
CSQ: CSCA_3964
CACE: CACET_c05400(purE2)
CTYK: CTK_C01050
CDY: F3K33_03245(larB)
CFER: D4Z93_06670(larB)
AMT: Amet_0480
CALE: FDN13_14145(larB)
CRS: FQB35_14415(larB)
CAZO: G3A45_06890(larB)
SARJ: HH195_01565(larB)
CTH: Cthe_0368
HSC: HVS_11380
CCE: Ccel_2205
CCEL: CCDG5_0275
CAPR: EQM14_02365(larB)
BPB: bpr_I0851
BFI: CIY_05750
BHU: bhn_I0728
RIX: RO1_10600
RIM: ROI_27020
CCT: CC1_07260
BLAU: DQQ01_06730(larB)
BPRO: PMF13cell1_01771(purE_1)
BLAB: EYS05_12420(larB)
CSO: CLS_11750
ACAC: EYQ97_14270(larB)
EHL: EHLA_1341
PXV: FXF36_05170(larB)
ANR: Ana3638_10435(larB)
RTO: RTO_25330
PDC: CDIF630_00316(larB)
ROC: HF520_12250(larB)
SLP: Slip_1769
SALQ: SYNTR_1277
DSY: DSY1760
DHD: Dhaf_2912
DRM: Dred_0149
DAE: Dtox_2119
PTH: PTH_2631(PurE)
DAU: Daud_0541
SGY: Sgly_1780
TFR: BR63_18680(larB)
HMO: HM1_1639
EMT: CPZ25_000630(larB) CPZ25_012240(larB) CPZ25_014825(larB)
AWO: Awo_c23020(purE2)
OVA: OBV_12510
OBJ: EIO64_06795(larB)
CTHM: CFE_2758
AMIJ: EQM06_00110(larB) EQM06_02740(larB)
AMIC: Ami3637_04085(larB)
ABUT: Ami103574_05255(larB)
BPRM: CL3_08650
BPRS: CK3_00530
TTE: TTE0770
THX: Thet_0715
TIT: Thit_0728
MTA: Moth_0579
CSC: Csac_1716
ATE: Athe_1636
CCHA: ELD05_07745(larB)
TTM: Tthe_1035
TSH: Tsac_1492
TOC: Toce_0387
HALS: D7D81_04010(larB)
APR: Apre_1705
PIV: NCTC13079_01024(purE_2)
VPR: Vpar_0986
MED: MELS_0953
MEG: DKB62_08915(larB)
MHG: MHY_28750
MFUN: GXM21_00895(larB)
PFT: JBW_02370
STED: SPTER_16670(larB)
AIN: Acin_0147
ERM: EYR00_11795(larB)
CGL: NCgl2382(Cgl2468)
CGB: cg2714
CGU: WA5_2382
CGT: cgR_2380
CGM: cgp_2714
CGJ: AR0_11845
CEF: CE2360
SLE: sle_12220(sle_12220)
SNZ: DC008_00255(larB)
BSAU: DWV08_13395(larB)
SERJ: SGUI_3204
ORN: DV701_00850(larB)
ORZ: FNH13_03625(larB)
GEZ: FE251_10200(larB)
HALT: IM660_11175(larB)
PACD: EGX94_05510(larB)
MPH: MLP_05650
MIK: FOE78_14110(larB)
MICG: GJV80_06155(larB)
RAIN: Rai3103_03780(larB)
PRV: G7070_00345(larB)
NCA: Noca_0169
NDK: I601_1386
NSN: EXE58_07885(larB)
KFL: Kfla_0199
KQI: F1D05_21590(larB)
ACTW: F7P10_09290(larB)
NOW: GBF35_28960(larB)
GOB: Gobs_1560
MMAR: MODMU_4369(purE)
AMD: AMED_3083
AMN: RAM_15680
AMM: AMES_3049
AMZ: B737_3050
PDX: Psed_1616
PSEE: FRP1_11805
PAUT: Pdca_54870(cpmA)
ASE: ACPL_4834
ACTN: L083_6348
AFS: AFR_19495
ACTS: ACWT_4703
CAI: Caci_4916
SNA: Snas_6462
FLH: EJ997_03660(larB)
RXY: Rxyl_3054
RUB: GBA63_17160(larB)
AFO: Afer_0098
ATQ: GH723_17035(larB)
ELE: Elen_1213
AEQ: AEQU_1343
PCAT: Pcatena_02460(larB)
SYN: sll1489
SYY: SYNGTS_3005(sll1489)
SYT: SYNGTI_3004(sll1489)
SYS: SYNPCCN_3003(sll1489)
SYQ: SYNPCCP_3003(sll1489)
SYJ: D082_34960(cpmA)
SYC: syc0382_d(cpmA)
SYW: SYNW1608
SYG: sync_0783
SYR: SynRCC307_1733(cpmA)
SYX: SynWH7803_1721(cpmA)
CYA: CYA_1548
CYB: CYB_1083
SYNR: KR49_13775
SYND: KR52_12455
SYNW: SynWH8103_01835(cpmA)
SYNC: CB0101_06135(larB)
TEL: tll1189(cpmA)
TVN: NIES2134_113260(cpmA)
THEC: FFX45_10930(larB)
HHG: XM38_028030(purE_2)
PMA: Pro_1352
PMM: PMM1278
PMT: PMT_0358
PRC: EW14_1577
PRM: EW15_1756
AMR: AM1_4350(cpmA)
THEU: HPC62_04410(larB)
MAR: MAE_62660
MPK: VL20_2101
ENN: FRE64_04235(larB)
CYT: cce_2642
TER: Tery_4722
ARP: NIES39_G01180(cpmA)
PAGH: NIES204_07690(cpmA)
OXY: HCG48_15105(larB)
LFS: HFV01_15745(larB)
GVI: gll1462
GLJ: GKIL_2578
ANA: alr3885
NSH: GXM_03816
AVA: Ava_1809
NAZ: Aazo_1171
ANN: EH233_07485(larB)
CALH: IJ00_15765
DOU: BMF77_00501(purE_1)
DFS: HGD76_13535(larB)
CCUR: IAR63_03850(larB)
TOQ: HCG51_13780(larB)
CTHE: Chro_1879
CEO: ETSB_1582
RCA: Rcas_1628
ATM: ANT_23250
KBS: EPA93_22320(larB)
TTR: Tter_1677
CAA: Caka_1886
AMU: Amuc_1594
AGL: PYTT_2055
VBS: EGM51_06065(larB)
RBA: RB8291(purE)
PSL: Psta_3844
RUL: UC8_49970
AHEL: Q31a_56700
TTF: THTE_3602
AMUC: Pan181_06130(purE_1)
PLM: Plim_0061
GIM: F1728_13315(larB)
FTJ: FTUN_0498
IPA: Isop_3494
SACI: Sinac_2656
PBOR: BSF38_04499(purE_1)
TPED: TPE_0943
ACA: ACP_0087
GRW: FTO74_05185(larB)
TALB: FTW19_20110(larB)
ABAS: ACPOL_5637
EDA: GWR55_06540(larB)
SUS: Acid_7127
PFER: IRI77_06800(larB)
EPO: Epro_1178
ETI: RSTT_616
RSD: TGRD_655
TLI: Tlie_1861
SBR: SY1_09440
GBA: J421_3384
FOP: FNB79_14675(larB)
TMA: TM0965
TMW: THMA_0988
TMQ: THMB_0988
TMX: THMC_0988
TPT: Tpet_1782
TRQ: TRQ2_1825
TNA: CTN_1611
TNP: Tnap_1783
ASAC: ATHSA_1769
GTL: EP073_08925(larB)
DTU: Dtur_1545
NDE: NIDE0532
NJA: NSJP_1575
TAV: G4V39_00640(larB)
TMAI: FVE67_04805(larB)
MJA: MJ_0165
MMP: MMP0809
MMD: GYY_04585
MMAD: MMJJ_01880(purE_1)
MAE: Maeo_1441
MVO: Mvol_0868
MTH: MTH_1286
MMG: MTBMA_c16710(purE1)
METC: MTCT_1168
METE: tca_01241(purE_1)
METK: FVF72_05150(larB)
MTHM: FZP57_08200(larB)
MST: Msp_1492
MRU: mru_2033(purE1)
MSI: Msm_1105
MEB: Abm4_1613
MMIL: sm9_2120(purE1)
MEYE: TL18_09775
MOL: YLM1_1475
METH: MBMB1_1894
MFC: BRM9_2234(purE)
MCUB: MCBB_2170
MFV: Mfer_1229
MKA: MK0675
AFU: AF_1275
FPL: Ferp_0316
GAC: GACE_0555
GAH: GAH_01781
MBAR: MSBR2_2096
MBAK: MSBR3_2077
MAC: MA_0428
MMA: MM_1616
MMAC: MSMAC_3073
METM: MSMTP_2953
MTHR: MSTHT_2152
MTHE: MSTHC_1131
MHOR: MSHOH_3769
MFZ: AOB57_005135(larB)
MBU: Mbur_2266(purE)
MMH: Mmah_0804
MPY: Mpsy_0859
MZI: HWN40_04365(larB)
MTP: Mthe_1601
MCJ: MCON_1809
MHI: Mhar_0646
MHU: Mhun_2916
MLA: Mlab_1018
MEMA: MMAB1_1024
MBN: Mboo_1732
MPL: Mpal_2200
MPD: MCP_0138
MEZ: Mtc_0876
RCI: RCIX1253
HALR: EFA46_003615(larB)
HMA: rrnAC2570(purE-2)
HHI: HAH_2995(purE2)
HALJ: G9465_04040(larB)
NMO: Nmlp_1014(purE2)
HUT: Huta_2256
HTI: HTIA_1993(purE)
HALA: Hrd1104_00880(larB)
HMU: Hmuk_1137
HALZ: E5139_08855(larB)
HALL: LC1Hm_0316
HSN: DV733_05605(larB)
HRR: HZS55_00115(larB)
HPEL: HZS54_00160(larB)
HLT: I7X12_13855(larB)
HARC: HARCEL1_01835(larB)
HWA: HQ_1978A(purE2)
HWC: Hqrw_2150(purE2)
HVO: HVO_0197(purE2)
HME: HFX_0196(purE-2)
HALE: G3A49_01375(larB)
HAQ: DU484_02365(larB)
HAJ: DU500_02770(larB)
HAER: DU502_00565(larB)
HRA: EI982_13055(larB)
HLM: DV707_01585(larB)
HALM: FCF25_07610(larB)
HLA: Hlac_2634
HALP: DOS48_13210(larB)
HALB: EKH57_10750(larB)
HEZZ: EO776_15015(larB)
HALQ: Hrr1229_007455(larB)
HALG: HUG10_13395(larB)
HALU: HUG12_02800(larB)
HTU: Htur_3754
HJT: DVR14_09295(larB)
HALY: HYG82_13220(larB)
NMG: Nmag_1949
NVR: FEJ81_18405(larB)
SALI: L593_15090
MEAR: Mpt1_c07930(purE1)
MARC: AR505_1595
IAG: Igag_1706
NMR: Nmar_0337
NIW: Nisw_03220(larB)
NCT: NMSP_1363
NEV: NTE_02799
TAA: NMY3_01946(purE_1)
NCV: NCAV_1618
NBV: T478_0267
NDV: NDEV_0299
KCR: Kcr_0479
BARC: AOA65_1139(purE)
BARB: AOA66_0335(purE_1)
LOKI: Lokiarch_44260(purE_2)
PSYT: DSAG12_01935(purE_2)
 » show all
Reference
1  [PMID:27114550]
  Authors
Desguin B, Soumillion P, Hols P, Hausinger RP
  Title
Nickel-pincer cofactor biosynthesis involves LarB-catalyzed pyridinium carboxylation and LarE-dependent sacrificial sulfur insertion.
  Journal
Proc Natl Acad Sci U S A 113:5598-603 (2016)
DOI:10.1073/pnas.1600486113
  Sequence
[lpl:lp_0105]
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.143
IUBMB Enzyme Nomenclature: 2.5.1.143
ExPASy - ENZYME nomenclature database: 2.5.1.143
BRENDA, the Enzyme Database: 2.5.1.143
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