| Entry |
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| Name |
pyridinium-3,5-biscarboxylic acid mononucleotide synthase;
LarB;
P2CMN synthase;
nicotinic acid adenine dinucleotide carboxylase/hydrolase;
NaAD carboxylase/hydrolase
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| Class |
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
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| Sysname |
deamido-NAD+:hydrogencarbonate nicotinate-beta-D-ribonucleotidyltransferase
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| Reaction(IUBMB) |
deamido-NAD+ + hydrogencarbonate = AMP + pyridinium-3,5-biscarboxylate mononucleotide [RN: R12017]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
AMP [CPD: C00020];
pyridinium-3,5-biscarboxylate mononucleotide [CPD: C21851]
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| Comment |
This enzyme, found in the bacterium Lactobacillus plantarum, is involved in the biosynthesis of a nickel-pincer cofactor. It carboxylates the pyridinium ring of deamido-NAD+ and cleaves the phosphoanhydride bond to release AMP and generate pyridinium-3,5-biscarboxylic acid mononucleotide (P2CMN).
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| History |
EC 2.5.1.143 created 2018
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| Orthology |
| K06898 | pyridinium-3,5-biscarboxylic acid mononucleotide synthase |
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| Genes |
» show all
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| Reference |
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| Authors |
Desguin B, Soumillion P, Hols P, Hausinger RP |
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| Title |
Nickel-pincer cofactor biosynthesis involves LarB-catalyzed pyridinium carboxylation and LarE-dependent sacrificial sulfur insertion. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.5.1.143 |
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| LinkDB |
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