KEGG   ENZYME: 2.5.1.146
Entry
EC 2.5.1.146                Enzyme                                 

Name
3-geranyl-3-[(Z)-2-isocyanoethenyl]indole synthase;
famD2 (gene name)
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
geranyl-diphosphate:3-[(Z)-2-isocyanoethenyl]-1H-indole geranyltransferase
Reaction(IUBMB)
geranyl diphosphate + 3-[(Z)-2-isocyanoethenyl]-1H-indole = 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole + diphosphate [RN:R12089]
Reaction(KEGG)
R12089
Substrate
geranyl diphosphate [CPD:C00341];
3-[(Z)-2-isocyanoethenyl]-1H-indole [CPD:C21893]
Product
3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole [CPD:C21837];
diphosphate [CPD:C00013]
Comment
The enzyme, characterized from the cyanobacterium Fischerella ambigua UTEX 1903, participates in the biosynthesis of hapalindole-type alkaloids.
History
EC 2.5.1.146 created 2018
Orthology
K22841  3-geranyl-3-[(Z)-2-isocyanoethenyl]indole synthase
Reference
1  [PMID:26629885]
  Authors
Li S, Lowell AN, Yu F, Raveh A, Newmister SA, Bair N, Schaub JM, Williams RM, Sherman DH
  Title
Hapalindole/Ambiguine Biogenesis Is Mediated by a Cope Rearrangement, C-C Bond-Forming Cascade.
  Journal
J Am Chem Soc 137:15366-9 (2015)
DOI:10.1021/jacs.5b10136
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.146
IUBMB Enzyme Nomenclature: 2.5.1.146
ExPASy - ENZYME nomenclature database: 2.5.1.146
BRENDA, the Enzyme Database: 2.5.1.146
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