Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy

dimethylallyl-diphosphate:all-trans-lycopene dimethylallyltransferase (hydrating, dihydrobisanhydrobacterioruberin-forming)

(1) dimethylallyl diphosphate + all-trans-lycopene + H2O = dihydroisopentenyldehydrorhodopin + diphosphate [RN:R12285];
(2) dimethylallyl diphosphate + isopentenyldehydrorhodopin + H2O = dihydrobisanhydrobacterioruberin + diphosphate [RN:R12286]

R12285 R12286
Reaction

dimethylallyl diphosphate [CPD:C00235];
all-trans-lycopene [CPD:C05432];
H2O [CPD:C00001];
isopentenyldehydrorhodopin [CPD:C22059]

The enzyme, characterized from the bacterium Dietzia sp. CQ4 and the halophilic archaea Halobacterium salinarum and Haloarcula japonica, is bifunctional. It catalyses the elongation of the C40 carotenoid all-trans-lycopene by attaching an isoprene unit at C-2 as well as the hydroxylation of the previous end of the molecule. The enzyme acts at both ends of the substrate, and combined with the action of EC 1.3.99.37, 1-hydroxy-2-isopentenylcarotenoid 3,4-desaturase, it forms the C50 carotenoid dihydrobisanhydrobacterioruberin. cf. EC 2.5.1.149, lycopene elongase/hydratase (flavuxanthin-forming).

EC 2.5.1.150 created 2018

1  [PMID:17008032]

Tao L, Yao H, Cheng Q

Genes from a Dietzia sp. for synthesis of C40 and C50 beta-cyclic carotenoids.

Gene 386:90-7 (2007)
DOI:10.1016/j.gene.2006.08.006

[ag:ABD24401 ABD24402]

2  [PMID:21840984]

Dummer AM, Bonsall JC, Cihla JB, Lawry SM, Johnson GC, Peck RF

Bacterioopsin-mediated regulation of bacterioruberin biosynthesis in Halobacterium salinarum.

J Bacteriol 193:5658-67 (2011)
DOI:10.1128/JB.05376-11

[hal:VNG_1682C]

3  [PMID:25712483]

Yang Y, Yatsunami R, Ando A, Miyoko N, Fukui T, Takaichi S, Nakamura S

Complete biosynthetic pathway of the C50 carotenoid bacterioruberin from lycopene in the extremely halophilic archaeon Haloarcula japonica.

J Bacteriol 197:1614-23 (2015)
DOI:10.1128/JB.02523-14

[ag:BAP82510]