| Entry |
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| Name |
geranylgeranyl diphosphate synthase;
geranylgeranyl-diphosphate synthase;
geranylgeranyl pyrophosphate synthetase;
geranylgeranyl-PP synthetase;
farnesyltransferase;
geranylgeranyl pyrophosphate synthase;
farnesyltranstransferase (obsolete)
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| Class |
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
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| Sysname |
(2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase
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| Reaction(IUBMB) |
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate [RN: R02061]
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| Reaction(KEGG) |
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| Substrate |
(2E,6E)-farnesyl diphosphate [CPD: C00448];
isopentenyl diphosphate [CPD: C00129]
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| Product |
diphosphate [CPD: C00013];
geranylgeranyl diphosphate [CPD: C00353]
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| Comment |
Some forms of this enzyme will also use geranyl diphosphate and dimethylallyl diphosphate as donors; it will not use larger prenyl diphosphates as efficient donors.
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| History |
EC 2.5.1.29 created 1984, modified 2011
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| Pathway |
| ec00900 | Terpenoid backbone biosynthesis |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K00804 | geranylgeranyl diphosphate synthase, type III |
| K13787 | geranylgeranyl diphosphate synthase, type I |
| K13789 | geranylgeranyl diphosphate synthase, type II |
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| Genes |
» show all
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| Reference |
1 |
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| Authors |
Sagami, H., Ishi, K. and Ogura, K. |
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| Title |
Occurrence and unusual properties of geranylgeranyl pyrophosphate synthetase of pig liver. |
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| Journal |
Biochem Int 3:669-675 (1981) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.5.1.29 |
| ExPASy - ENZYME nomenclature database: | 2.5.1.29 |
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| LinkDB |
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