Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy

S-adenosyl-L-methionine:nocardicin-G 3-amino-3-carboxypropyltransferase

S-adenosyl-L-methionine + nocardicin G = S-methyl-5'-thioadenosine + isonocardicin C [RN:R10881]

R10881;
(other) R03072
Reaction

S-adenosyl-L-methionine [CPD:C00019];
nocardicin G [CPD:C17355]

The enzyme, characterized from the bacterium Nocardia uniformis, is involved in the biosynthesis of the beta-lactam antibiotic nocardicin A. The enzyme can act on nocardicin E, F, and G, producing isonocardicin A, B, and C, respectively. However, the in vivo substrate is believed to be nocardicin G [3].

EC 2.5.1.38 created 1992, modified 2016

1

Wilson, B.A., Bantia, S., Salituro, G.M., Reeve, A.M. and Townsend, C.A.

Cell-free biosynthesis of nocardicin A from nocardicin E and S-adenosylmethionine.

J Am Chem Soc 110:8238-8239 (1988)

2  [PMID:9804844]

Reeve AM, Breazeale SD, Townsend CA

Purification, characterization, and cloning of an S-adenosylmethionine-dependent 3-amino-3-carboxypropyltransferase in nocardicin biosynthesis.

J Biol Chem 273:30695-703 (1998)
DOI:10.1074/jbc.273.46.30695

3  [PMID:15629944]

Kelly WL, Townsend CA

Mutational analysis of nocK and nocL in the nocardicin a producer Nocardia uniformis.

J Bacteriol 187:739-46 (2005)
DOI:10.1128/JB.187.2.739-746.2005