| Entry |
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| Name |
O-acetylhomoserine aminocarboxypropyltransferase;
O-acetyl-L-homoserine acetate-lyase (adding methanethiol);
O-acetyl-L-homoserine sulfhydrolase;
O-acetylhomoserine (thiol)-lyase;
O-acetylhomoserine sulfhydrolase;
methionine synthase (misleading)
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| Class |
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
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| Sysname |
O-acetyl-L-homoserine:methanethiol 3-amino-3-carboxypropyltransferase
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| Reaction(IUBMB) |
O-acetyl-L-homoserine + methanethiol = L-methionine + acetate [RN: R00651]
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| Reaction(KEGG) |
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| Substrate |
O-acetyl-L-homoserine [CPD: C01077];
methanethiol [CPD: C00409]
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| Product |
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| Comment |
Also reacts with other thiols and H2S, producing homocysteine or thioethers. The name methionine synthase is more commonly applied to EC 2.1.1.13, methionine synthase. The enzyme from baker's yeast also catalyses the reaction of EC 2.5.1.47 cysteine synthase, but more slowly.
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| History |
EC 2.5.1.49 created 1972 as EC 4.2.99.10, transferred 2002 to EC 2.5.1.49
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| Pathway |
| ec00270 | Cysteine and methionine metabolism |
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| Orthology |
| K01740 | O-acetylhomoserine (thiol)-lyase |
| K17069 | O-acetylhomoserine/O-acetylserine sulfhydrylase |
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| Genes |
» show all
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| Reference |
1 |
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| Authors |
Kerr, D. |
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| Title |
O-Acetylhomoserine sulfhydrylase (Neurospora). |
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| Journal |
Methods Enzymol 17B:446-450 (1971) |
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| Reference |
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| Authors |
Smith IK, Thompson JF. |
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| Title |
Utilization of S-methylcysteine and methylmercaptan by methionineless mutants of Neurospora and the pathway of their conversion to methionine. II. Enzyme studies. |
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| Journal |
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| Reference |
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| Authors |
Yamagata S, Takeshima K. |
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| Title |
O-Acetylserine and O-acetylhomoserine sulfhydrylase of yeast. Further purification and characterization as a pyridoxal enzyme. |
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| Journal |
J Biochem (Tokyo) 80:777-85 (1976) |
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| Reference |
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| Authors |
Yamagata S. |
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| Title |
O-Acetylserine and O-acetylhomoserine sulfhydrylase of yeast. Subunit structure. |
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| Journal |
J Biochem (Tokyo) 80:787-97 (1976) |
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| Reference |
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| Authors |
Yamagata S, Takeshima K, Naiki N. |
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| Title |
Evidence for the identity of O-acetylserine sulfhydrylase with O-acetylhomoserine sulfhydrylase in yeast. |
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| Journal |
J Biochem (Tokyo) 75:1221-9 (1974) |
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| Reference |
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| Authors |
Yamagata S. |
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| Title |
Roles of O-acetyl-L-homoserine sulfhydrylases in micro-organisms. |
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| Journal |
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| Reference |
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| Authors |
Shimizu H, Yamagata S, Masui R, Inoue Y, Shibata T, Yokoyama S, Kuramitsu S, Iwama T. |
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| Title |
Cloning and overexpression of the oah1 gene encoding O-acetyl-L-homoserine sulfhydrylase of Thermus thermophilus HB8 and characterization of the gene product. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.5.1.49 |
| ExPASy - ENZYME nomenclature database: | 2.5.1.49 |
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| LinkDB |
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