| Entry |
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| Name |
N-acetylneuraminate synthase;
(NANA)condensing enzyme;
N-acetylneuraminate pyruvate-lyase (pyruvate-phosphorylating);
NeuAc synthase
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| Class |
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
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| Sysname |
phosphoenolpyruvate:N-acetyl-D-mannosamine C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)
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| Reaction(IUBMB) |
phosphoenolpyruvate + N-acetyl-D-mannosamine + H2O = phosphate + N-acetylneuraminate [RN: R01804]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| History |
EC 2.5.1.56 created 1972 as EC 4.1.3.19, transferred 2002 to EC 2.5.1.56
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| Pathway |
| ec00520 | Amino sugar and nucleotide sugar metabolism |
| ec00541 | O-Antigen nucleotide sugar biosynthesis |
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| Orthology |
| K01654 | N-acetylneuraminate synthase |
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| Genes |
» show all
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| Reference |
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| Authors |
BLACKLOW RS, WARREN L. |
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| Title |
Biosynthesis of sialic acids by Neisseria meningitidis. |
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| Journal |
J Biol Chem 237:3520-6 (1962) |
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| Reference |
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| Authors |
Komaki E, Ohta Y, Tsukada Y. |
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| Title |
Purification and characterization of N-acetylneuraminate synthase from Escherichia coli K1-M12. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.5.1.56 |
| ExPASy - ENZYME nomenclature database: | 2.5.1.56 |
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| LinkDB |
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