KEGG   ENZYME: 2.5.1.57
Entry
EC 2.5.1.57                 Enzyme                                 

Name
N-acylneuraminate-9-phosphate synthase;
N-acetylneuraminate 9-phosphate lyase;
N-acetylneuraminate 9-phosphate sialic acid 9-phosphate synthase;
N-acetylneuraminate 9-phosphate synthetase;
N-acylneuraminate-9-phosphate pyruvate-lyase (pyruvate-phosphorylating);
sialic acid 9-phosphate synthetase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
phosphoenolpyruvate:N-acyl-D-mannosamine-6-phosphate 1-(2-carboxy-2-oxoethyl)transferase
Reaction(IUBMB)
phosphoenolpyruvate + N-acyl-D-mannosamine 6-phosphate + H2O = N-acylneuraminate 9-phosphate + phosphate [RN:R02769]
Reaction(KEGG)
R02769 > R04435
Substrate
phosphoenolpyruvate [CPD:C00074];
N-acyl-D-mannosamine 6-phosphate [CPD:C00686];
H2O [CPD:C00001]
Product
N-acylneuraminate 9-phosphate [CPD:C01200];
phosphate [CPD:C00009]
Comment
Acts on N-glycoloyl and N-acetyl-derivatives.
History
EC 2.5.1.57 created 1972 as EC 4.1.3.20, transferred 2002 to EC 2.5.1.57
Pathway
ec00520  Amino sugar and nucleotide sugar metabolism
ec01100  Metabolic pathways
Orthology
K05304  sialic acid synthase
Genes
HSA: 54187(NANS)
PTR: 743934(NANS)
PPS: 100982112(NANS)
GGO: 101124502(NANS)
PON: 100446862(NANS)
NLE: 100603154(NANS)
MCC: 715459(NANS)
MCF: 102120030(NANS)
CSAB: 103219150(NANS)
RRO: 104657773(NANS)
RBB: 108539113(NANS)
CJC: 100411585(NANS)
SBQ: 101027621(NANS)
MMU: 94181(Nans)
MCAL: 110292645(Nans)
MPAH: 110323062(Nans)
RNO: 298071(Nans)
MUN: 110551128(Nans)
CGE: 100767837(Nans)
NGI: 103749137(Nans)
HGL: 101721582(Nans)
CCAN: 109697287(Nans)
OCU: 100356934(NANS)
TUP: 102496776(NANS)
CFA: 481624(NANS)
VVP: 112930767(NANS)
AML: 100471912(NANS)
UMR: 103678504(NANS)
UAH: 113260417(NANS)
ORO: 101377441(NANS)
ELK: 111146174
FCA: 101092303(NANS)
PTG: 102952743(NANS)
PPAD: 109270098(NANS)
AJU: 106981299(NANS)
BTA: 540602(NANS)
BOM: 102266035(NANS)
BIU: 109563072(NANS)
BBUB: 102402717(NANS)
CHX: 102171423(NANS)
OAS: 101104048(NANS)
SSC: 100155883(NANS)
CFR: 102511644(NANS)
CDK: 105086903(NANS)
BACU: 103016138(NANS)
LVE: 103074242(NANS)
OOR: 101286113(NANS)
DLE: 111187968(NANS)
PCAD: 102975186(NANS)
ECB: 100064126(NANS)
EPZ: 103550229(NANS)
EAI: 106842931(NANS)
MYB: 102254698(NANS)
MYD: 102770256(NANS)
MNA: 107544993(NANS)
HAI: 109386412(NANS)
DRO: 112304493(NANS)
PALE: 102882391(NANS)
RAY: 107511690(NANS)
MJV: 108386331(NANS)
LAV: 100659127(NANS)
TMU: 101361417
MDO: 100014569(NANS)
SHR: 100915225(NANS)
PCW: 110220562(NANS)
OAA: 100074951(NANS)
GGA: 427283(NANS)
MGP: 100540972(NANS)
CJO: 107306381(NANS)
NMEL: 110389693(NANS)
APLA: 101793548(NANS)
ACYG: 106046483(NANS)
TGU: 100227675(NANS)
LSR: 110472303(NANS)
SCAN: 103821217(NANS)
GFR: 102036907(NANS)
FAB: 101817049(NANS)
PHI: 102108606(NANS)
PMAJ: 107198262(NANS)
CCAE: 111940921(NANS)
CCW: 104689769(NANS)
ETL: 114056942(NANS)
FPG: 101910977(NANS)
FCH: 102058691(NANS)
CLV: 102088004(NANS)
EGZ: 104135026(NANS)
NNI: 104014067(NANS)
ACUN: 113489989(NANS)
PADL: 103923247(NANS)
AAM: 106487451(NANS)
ASN: 102371122(NANS)
AMJ: 102562418(NANS)
CMY: 102930222(NANS)
CPIC: 101940249(NANS)
ACS: 100558551(nans)
PVT: 110077827(NANS)
PBI: 103051012(NANS)
PMUR: 107293127(NANS)
TSR: 106556782(NANS)
PMUA: 114587657(NANS)
GJA: 107122992(NANS)
XLA: 432051 447417(nans.L)
XTR: 100492893(nans)
NPR: 108783786(NANS)
DRE: 322780(nansa) 492779(nansb)
IPU: 100528493(nans) 108260162
PHYP: 113531522(nans)
AMEX: 111195185(nans)
EEE: 113568448(nans) 113589926
TRU: 778024(nans)
LCO: 104922341(nans)
OLA: 101166198(nans)
XMA: 102234709(nans)
XCO: 114145362(nans)
PRET: 103467988(nans) 103472627
ALIM: 106528334(nans)
AOCE: 111575007(nans)
MALB: 109953770(nans)
ELS: 105022900(nans)
SFM: 108920829
PKI: 111855408(nans)
CMK: 103177631(nans) 103177633
RTP: 109938218(nans)
SPU: 577884
APLC: 110979925
DME: Dmel_CG5232(NANS)
DER: 6553702
DSE: 6606666
DSI: Dsimw501_GD18832(Dsim_GD18832)
DSR: 110190443
DPE: 6598731
DMN: 108156913
DWI: 6650267
DAZ: 108621816
DNV: 108653385
DHE: 111601415
MDE: 101899077
LCQ: 111687367
AAG: 5563645
AALB: 109400878
TCA: 103312199
DPA: 109539228
ATD: 109597067
NVL: 108567369
BMOR: 101744099
BMAN: 114246626
PRAP: 110994857
HAW: 110380482
PXY: 105391284
DNX: 107161705
AGS: 114120104
RMD: 113549718
BTAB: 109035180
CLEC: 106666066
ZNE: 110829049
FCD: 110842189
PVM: 113802701
TUT: 107368038
CSCU: 111619307
PTEP: 107452120
EHX: EMIHUDRAFT_437804(NEUB)
SLAC: SKTS_36140
AMYT: AMYT_2597
ARC: ABLL_2687
PCA: Pcar_1277(neuB)
DVM: DvMF_1832
DMA: DMR_13530
DGG: DGI_4066
DFL: DFE_1272
DAS: Daes_2970
DPI: BN4_12645
PPRF: DPRO_1430
RLG: Rleg_0440
RPE: RPE_4236
BVR: BVIR_1970
BLAG: BLTE_00400(neuB)
HDI: HDIA_0896(pseI)
MALG: MALG_05073
RCE: RC1_3771(nans)
HLI: HLI_08585
SLAU: SLA_6887
MUC: MuYL_3260
FJG: BB050_02206(legI)
DOK: MED134_13631(neuB)
DDO: I597_1525(legI)
NDO: DDD_2293
MESQ: C7H62_1954
MAC: MA_3767
 » show all
Reference
1  [PMID:13743311]
  Authors
ROSEMAN S, JOURDIAN GW, WATSON D, ROOD R.
  Title
Enzymatic synthesis of sialic acid 9-phosphates.
  Journal
Proc Natl Acad Sci U S A 47:958-61 (1961)
DOI:10.1073/pnas.47.7.958
Reference
2  [PMID:5928202]
  Authors
Watson DR, Jourdian GW, Roseman S.
  Title
The sialic acids. 8. Sialic acid 9-phosphate synthetase.
  Journal
J Biol Chem 241:5627-36 (1966)
Reference
3  [PMID:10873658]
  Authors
Nakata D, Close BE, Colley KJ, Matsuda T, Kitajima K
  Title
Molecular cloning and expression of the mouse N-acetylneuraminic acid 9-phosphate synthase which does not have deaminoneuraminic acid (KDN) 9-phosphate synthase activity.
  Journal
Biochem Biophys Res Commun 273:642-8 (2000)
DOI:10.1006/bbrc.2000.2983
  Sequence
[mmu:94181]
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.57
IUBMB Enzyme Nomenclature: 2.5.1.57
ExPASy - ENZYME nomenclature database: 2.5.1.57
BRENDA, the Enzyme Database: 2.5.1.57
CAS: 9031-58-7
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