Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy

geranyl-diphosphate:isopentenyl-diphosphate geranylcistransferase

geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2Z,6E)-farnesyl diphosphate [RN:R08528]

R08528
Reaction

geranyl diphosphate [CPD:C00341];
isopentenyl diphosphate [CPD:C00129]

Requires Mg2+ or Mn2+ for activity. The product of this reaction is an intermediate in the synthesis of decaprenyl phosphate, which plays a central role in the biosynthesis of most features of the mycobacterial cell wall, including peptidoglycan, linker unit galactan and arabinan. Neryl diphosphate can also act as substrate.

EC 2.5.1.68 created 2007, modified 2010

1  [PMID:11152452]

Schulbach MC, Mahapatra S, Macchia M, Barontini S, Papi C, Minutolo F, Bertini S, Brennan PJ, Crick DC.

Purification, enzymatic characterization, and inhibition of the Z-farnesyl diphosphate synthase from Mycobacterium tuberculosis.

J Biol Chem 276:11624-30 (2001)
DOI:10.1074/jbc.M007168200

[mtu:Rv1086]