| Entry |
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| Name |
7-dimethylallyltryptophan synthase;
7-DMATS
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| Class |
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
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| Sysname |
dimethylallyl-diphosphate:L-tryptophan 7-dimethylallyltransferase
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| Reaction(IUBMB) |
dimethylallyl diphosphate + L-tryptophan = diphosphate + 7-(3-methylbut-2-enyl)-L-tryptophan [RN: R09638]
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| Reaction(KEGG) |
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| Substrate |
dimethylallyl diphosphate [CPD: C00235];
L-tryptophan [CPD: C00078]
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| Product |
diphosphate [CPD: C00013];
7-(3-methylbut-2-enyl)-L-tryptophan [CPD: C19767]
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| Comment |
This enzyme is more flexible towards the aromatic substrate than EC 2.5.1.34 (4-dimethylallyltryptophan synthase), but similar to that enzyme, accepts only dimethylallyl diphosphate as the prenyl donor.
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| History |
EC 2.5.1.80 created 2010
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| Orthology |
| K14131 | tryptophan 7-dimethylallyltransferase |
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| Genes |
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| Reference |
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| Authors |
Kremer A, Li SM |
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| Title |
Potential of a 7-dimethylallyltryptophan synthase as a tool for production of prenylated indole derivatives. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Kremer A, Westrich L, Li SM |
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| Title |
A 7-dimethylallyltryptophan synthase from Aspergillus fumigatus: overproduction, purification and biochemical characterization. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.5.1.80 |
| ExPASy - ENZYME nomenclature database: | 2.5.1.80 |
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| LinkDB |
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