| Entry |
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| Name |
hexaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific];
HexPS(ambiguous);
(all-E) hexaprenyl diphosphate synthase;
(all-trans) hexaprenyl diphosphate synthase;
hexaprenyl pyrophosphate synthase (ambiguous);
HexPPs (ambiguous);
hexaprenyl diphosphate synthase (ambiguous)
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| Class |
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
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| Sysname |
geranylgeranyl-diphosphate:isopentenyl-diphosphate transferase (adding 2 isopentenyl units)
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| Reaction(IUBMB) |
geranylgeranyl diphosphate + 2 isopentenyl diphosphate = 2 diphosphate + all-trans-hexaprenyl diphosphate [RN: R09246]
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| Reaction(KEGG) |
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| Substrate |
geranylgeranyl diphosphate [CPD: C00353];
isopentenyl diphosphate [CPD: C00129]
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| Product |
diphosphate [CPD: C00013];
all-trans-hexaprenyl diphosphate [CPD: C01230]
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| Comment |
The enzyme prefers geranylgeranyl diphosphate to farnesyl diphosphate as an allylic substrate and does not show activity for geranyl diphosphate and dimethylallyl diphosphate. Requires Mg2+ [1].
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| History |
EC 2.5.1.82 created 1984 as EC 2.5.1.33, part transferred 2010 to EC 2.5.1.82
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| Pathway |
| ec00900 | Terpenoid backbone biosynthesis |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K05355 | hexaprenyl-diphosphate synthase |
| K21268 | hexaprenyl diphosphate synthase |
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| Genes |
» show all
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| Reference |
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| Authors |
Hemmi H, Ikejiri S, Yamashita S, Nishino T |
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| Title |
Novel medium-chain prenyl diphosphate synthase from the thermoacidophilic archaeon Sulfolobus solfataricus. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Hemmi H, Noike M, Nakayama T, Nishino T |
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| Title |
Change of product specificity of hexaprenyl diphosphate synthase from Sulfolobus solfataricus by introducing mimetic mutations. |
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| Journal |
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| Reference |
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| Authors |
Sun HY, Ko TP, Kuo CJ, Guo RT, Chou CC, Liang PH, Wang AH |
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| Title |
Homodimeric hexaprenyl pyrophosphate synthase from the thermoacidophilic crenarchaeon Sulfolobus solfataricus displays asymmetric subunit structures. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.5.1.82 |
| ExPASy - ENZYME nomenclature database: | 2.5.1.82 |
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| LinkDB |
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