| Entry |
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| Name |
tritrans,polycis-undecaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific]
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| Class |
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
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| Sysname |
geranylgeranyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 7 isopentenyl units)
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| Reaction(IUBMB) |
geranylgeranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + tritrans,heptacis-undecaprenyl diphosphate [RN: R09730]
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| Reaction(KEGG) |
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| Substrate |
geranylgeranyl diphosphate [CPD: C00353];
isopentenyl diphosphate [CPD: C00129]
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| Product |
diphosphate [CPD: C00013];
tritrans,heptacis-undecaprenyl diphosphate [CPD: C19852]
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| Comment |
This enzyme is involved in the biosynthesis of the glycosyl carrier lipid in some archaebacteria. Unlike EC 2.5.1.31, its counterpart in most bacteria, it prefers geranylgeranyl diphosphate to farnesyl diphosphate as the allylic substrate, resulting in production of a tritrans,polycis variant of undecaprenyl diphosphate [1].
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| History |
EC 2.5.1.89 created 2010, modified 2011
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| Pathway |
| ec00900 | Terpenoid backbone biosynthesis |
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| Orthology |
| K15888 | tritrans,polycis-undecaprenyl-diphosphate synthase [geranylgeranyl-diphosphate specific] |
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| Genes |
» show all
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| Reference |
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| Authors |
Hemmi H, Yamashita S, Shimoyama T, Nakayama T, Nishino T |
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| Title |
Cloning, expression, and characterization of cis-polyprenyl diphosphate synthase from the thermoacidophilic archaeon Sulfolobus acidocaldarius. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.5.1.89 |
| ExPASy - ENZYME nomenclature database: | 2.5.1.89 |
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| LinkDB |
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