Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy

dimethylallyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 2 isopentenyl units)

dimethylallyl diphosphate + 2 isopentenyl diphosphate = 2 diphosphate + (2Z,6Z)-farnesyl diphosphate [RN:R09633];
(1a) dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + neryl diphosphate [RN:R01659];
(1b) neryl diphosphate + isopentenyl diphosphate = diphosphate + (2Z,6Z)-farnesyl diphosphate [RN:R12638]

R01659 R09633 R12638
Reaction

dimethylallyl diphosphate [CPD:C00235];
isopentenyl diphosphate [CPD:C00129];
neryl diphosphate [CPD:C02569]

This enzyme, originally characterized from wild tomato, specifically forms (2Z,6Z)-farnesyl diphosphate via neryl diphosphate and isopentenyl diphosphate. In wild tomato it is involved in the biosynthesis of several sesquiterpenes. See also EC 2.5.1.68 [(2Z,6E)-farnesyl diphosphate synthase] and EC 2.5.1.10 [(2E,6E)-farnesyl diphosphate synthase].

EC 2.5.1.92 created 2010, modified 2011

1  [PMID:19155349]

Sallaud C, Rontein D, Onillon S, Jabes F, Duffe P, Giacalone C, Thoraval S, Escoffier C, Herbette G, Leonhardt N, Causse M, Tissier A

A novel pathway for sesquiterpene biosynthesis from Z,Z-farnesyl pyrophosphate in the wild tomato Solanum habrochaites.

Plant Cell 21:301-17 (2009)
DOI:10.1105/tpc.107.057885

[ag:ACJ38408]